排序方式： 共有19条查询结果，搜索用时 15 毫秒
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Ron C. Gaba R. Peter Lokken Ryan M. Hickey Andrew J. Lipnik Robert J. Lewandowski Riad Salem Daniel B. Brown T. Gregory Walker James E. Silberzweig Mark Otto Baerlocher Ana Maria Echenique Mehran Midia Jason W. Mitchell Siddharth A. Padia Suvranu Ganguli Thomas J. Ward Jeffrey L. Weinstein Boris Nikolic Sean R. Dariushnia 《Journal of vascular and interventional radiology : JVIR》2017,28(9):1210-1223.e3
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Are prophylactic antibiotics necessary prior to transarterial chemoembolization for hepatocellular carcinoma in patients with native biliary anatomy? 
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Lipnik K Greco O Scott S Knapp E Mayrhofer E Rosenfellner D Günzburg WH Salmons B Hohenadl C 《Virology》2006,349(1):121-133
To facilitate a more efficient radiation and chemotherapy of mammary tumours, synthetic enhancer elements responsive to hypoxia and ionizing radiation were coupled to the mammary-specific minimal promoter of the murine whey acidic protein (WAP) encoding gene. The modified WAP promoter was introduced into a retroviral promoter conversion (ProCon) vector. Expression of a transduced reporter gene in response to hypoxia and radiation was analysed in stably infected mammary cancer cell lines and an up to 9-fold increase in gene expression demonstrated in comparison to the respective basic vector. Expression analyses in vitro, moreover, demonstrated a widely preserved mammary cell-specific promoter activity. For in vivo analyses, xenograft tumours consisting of infected human mammary adenocarcinoma cells were established in SCID/beige mice. Immunohistochemical analyses demonstrated a hypoxia-specific, markedly increased WAP promoter-driven expression in these tumours. Thus, this retroviral vector will facilitate a targeted gene therapeutic approach exploiting the unique environmental condition in solid tumours. 相似文献
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Matthew D. Taussig Mary Ellen Irene Koran Samdeep K. Mouli Asma Ahmad Sunil Geevarghese Jennifer C. Baker Andrew J. Lipnik Fil Banovac Daniel B. Brown 《HPB : the official journal of the International Hepato Pancreato Biliary Association》2017,19(5):458-464
Background
Prospectively predicting response to intra-arterial therapy for hepatocellular carcinoma (HCC) is challenging. Neutrophil/lymphocyte ratio (NLR) is a serum biomarker that is associated with survival for multiple malignancies. It was hypothesized that increased NLR would be associated with early disease progression after intra-arterial therapy of HCC.Methods
The outcomes of 86 treatment-naïve patients who had chemoembolization or radioembolization of HCC between July 2013–July 2014 were reviewed. Pre-treatment laboratory tests and imaging were used to measure NLR, Child-Pugh (CP) score, tumor number and tumor size. High/low NLR groups were defined as >3 and <3 respectively. Follow-up imaging at two months with assessed response using modified response criteria in solid tumors (mRECIST).Results
NLR >3 was seen in 25/86 patients (range 3.0–21.6). NLR >3 patients had a significantly higher baseline CP score. Comorbidities were otherwise similar between groups as was tumor number/size. Disease control was significantly worse (p = 0.014) with NLR >3. Logistic regression for tumor response revealed NLR >3 as the best predictor of early progression (p < 0.0001).Discussion
NLR may be a serologic biomarker of early progressive disease after intra-arterial therapy of HCC. Future research should focus on outcomes by treatment type or potentially combining arterial therapies with ablation and/or targeted biologic agents. 相似文献8.
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Jan Hansmann Maximilian J. Evers James T. Bui R. Peter Lokken Andrew J. Lipnik Ron C. Gaba Charles E. Ray 《Journal of vascular and interventional radiology : JVIR》2017,28(9):1224-1231.e2