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排序方式: 共有54条查询结果,搜索用时 15 毫秒
1.
Maria Volokhova Anna Shugai Masahiko Tsujimoto Anna-Liisa Kubo Sven Telliskivi Mait Nigul Peep Uudeküll Heiki Vija Olesja M. Bondarenko Jasper Adamson Anne Kahru Raivo Stern Liis Seinberg 《Materials》2022,15(6)
Nanoparticles with SiO coating were synthesized to have a cubic iron core. These were found to have saturation magnetization very close to the highest possible value of any iron-containing nanoparticles and the bulk iron saturation magnetization. The in vitro toxicology studies show that they are highly biocompatible and possess better MRI contrast agent potential than iron oxide NPs. 相似文献
2.
Hiie Soeorg Kristi Huik Ülle Parm Mari‐Liis Ilmoja Tuuli Metsvaht Irja Lutsar 《APMIS : acta pathologica, microbiologica, et immunologica Scandinavica》2017,125(1):63-73
Late‐onset sepsis (LOS) in preterm neonates is increasingly reported to be associated with gut‐colonizing Staphylococcus epidermidis. We aimed to describe the molecular epidemiology of S. epidermidis colonizing the gut of neonates hospitalized in two neonatal intensive care units. S. epidermidis from rectal swabs were typed by multilocus variable‐number tandem‐repeat analysis (MLVA), randomly chosen isolates of predominant MLVA types additionally by multilocus sequence typing. Antimicrobial susceptibility, the presence of icaA, IS256, arginine catabolic mobile element (ACME), agr type, and SCCmec type were determined. Of 276 neonates (38.4%), 106 were colonized with S. epidermidis, yielding a total of 139 isolates (62 in one unit and 77 in another unit). Of the 55 MLVA types identified, the five predominant detected in both units corresponded to sequence type (ST) 2, ST5, and ST59 or its single locus variant ST81 and formed three major MLVA clonal complexes accounting for 74.8% of all isolates. Overall, the prevalence of mecA, icaA, IS256, and ACME was 91.4%, 28.1%, 64%, and 77%, respectively. Of the mecA‐positive isolates (n = 127), 43.9% carried SCCmec type IV. Of eight episodes of LOS, four were caused by ST2 and two by ST5. Preventing gut colonization with nosocomial epidemic S. epidermidis in hospitalized neonates could contribute to the prevention of LOS. 相似文献
3.
Two murine tumor cell lines derived from the same origin and having different intrinsic radiosensitivities, one radiosensitive, SHA3K4-Ic (Ic), and the other relatively radioresistant, SHA3K4-III19 (III19), were compared in vivo regarding oxygenation, proliferation, and tumor response during fractionated irradiation. Tumors transplanted into nude mice were irradiated five times a week with a fraction size of 3 Gy up to a total dose of 30 Gy. Oxygenation status was analyzed using a non-invasive system with near infrared reflection spectroscopy. Proliferation status was quantified as the percentage of bromodeoxyuridine-labelled tumor cells and the percentage of necrotic area. All parameters were compared between untreated and irradiated tumors of the two lines. The oxygenation status in the untreated tumors did not correlate with tumor response. However, for the radioresponsive line, Ic, O2 saturation was significantly higher in irradiated than in untreated tumors, suggesting the existence of reoxygenation following fractionated irradiation. On the other hand, oxygenation status remained almost unchanged for the non-radioresponsive line, III19. Proliferation status did not correlate with tumor response. The results indicate that comprehensive investigations, including oxygen measurements, are necessary to understand the various intrinsic and extrinsic factors determining in vivo tumor radioresponse. 相似文献
4.
Tianwei Xu Linda L. Magnusson Hanson Theis Lange Liis Starkopf Hugo Westerlund Ida E. H. Madsen Reiner Rugulies Jaana Pentti Sari Stenholm Jussi Vahtera Åse M. Hansen Mika Kivimäki Naja H. Rod 《Diabetologia》2018,61(1):75-83
Aims/hypothesis
The aim of this multicohort study was to examine whether employees exposed to social stressors at work, such as workplace bullying and violence, have an increased risk of type 2 diabetes.Methods
The study included 45,905 men and women (40–65 years of age and free of diabetes at baseline) from four studies in Sweden, Denmark and Finland. Workplace bullying and violence were self-reported at baseline. Incident diabetes was ascertained through national health and medication records and death registers. Marginal structural Cox models adjusted for age, sex, country of birth, marital status and educational level were used for the analyses.Results
Nine per cent of the population reported being bullied at work and 12% were exposed to workplace violence or threats of violence. Bullied participants had a 1.46 (95% CI 1.23, 1.74) times higher risk of developing diabetes compared with non-bullied participants. Exposure to violence or threats of violence was also associated with a higher risk of diabetes (HR 1.26 [95% CI 1.02, 1.56]). The risk estimates attenuated slightly when taking BMI into account, especially for bullying. The results were similar for men and women, and were consistent across cohorts.Conclusions/interpretation
We found a higher risk of incident type 2 diabetes among employees exposed to bullying or violence in the workplace. Further research is needed to determine whether policies to reduce bullying and violence at work may reduce the incidence of type 2 diabetes in working populations. Research on the mechanisms is also highly warranted.5.
6.
Hannes Bohman Ulf Jonsson Anne‐Liis Von Knorring Lars Von Knorring Aivar Päären Gunilla Olsson 《Acta paediatrica (Oslo, Norway : 1992)》2010,99(11):1724-1730
Aim: This study aims to investigate the prevalence of somatic symptoms in depressed adolescents and in their healthy peers. A second aim is to investigate the correlation, in the depressed adolescents, between the number of somatic symptoms and severe concurrent symptoms, signs and life events. Methods: The total population of 16–17 year olds – in the city of Uppsala – was screened for depression and then interviewed using a structured interview questionnaire. Depressed subjects and matched controls were identified. A total of 177 pairs were used for pair‐wise analyses of somatic symptoms. Severe symptoms, signs and life events were selected for analysing their relation to depression with somatic symptoms. Results: The adolescents with depressive disorders experienced considerably more somatic symptoms than their healthy controls. The duration and depth of the depression correlated with the number of somatic symptoms. There was a strong correlation between depression with many somatic symptoms and suicidal plans/thoughts, suicidal attempts, disruptive behaviour, as well as multiple stressful relationships. Conclusion: This study demonstrates that somatic symptoms are common in adolescent depression. Multiple somatic symptoms within depression imply a higher severity in terms of duration, depth and psychiatric comorbidity. The strong correlation with suicidal plans, suicidal attempts and disruptive behaviour is concerning. 相似文献
7.
8.
Tomson K Merenäkk L Loit HM Mäestu J Harro J 《Progress in neuro-psychopharmacology & biological psychiatry》2011,35(8):1857-1862
The serotonin transporter gene promoter region polymorphism (5-HTTLPR) has been linked to psychiatric disorders, mostly anxiety and affective disorders. In elderly populations 5-HTTLPR polymorphism has also been reported to be associated with serum lipid levels. We have examined the interaction of the 5-HTTLPR polymorphism and the markers of lipid metabolism at young age in a longitudinal, population-representative cohort study. The sample of the Estonian Children Personality Behaviour and Health Study (initially cohorts of 9 and 15 year old children, complete lipid and genotype data for n = 1176) was examined throughout 10 years. Subjects were genotyped and the levels of low-density lipoproteins, high-density lipoproteins, triglycerides, and total cholesterol were measured. Children and adolescents carrying the s allele of the 5-HTTLPR polymorphism had lower levels of low-density lipoprotein and total cholesterol. At the age of 25, the s allele carriers had higher levels of high-density lipoproteins. These associations were independent of gender. Thus the 5-HTTLPR can be associated with the serum lipid levels and in particular low-density lipoproteins already in a young age. 相似文献
9.
Tuuli Metsvaht Mari‐Liis Ilmoja Ülle Parm Mirjam Merila Lea Maipuu Piia Müürsepp Kadri Julge Epp Sepp Irja Lutsar 《Pediatrics international》2011,53(6):873-880
Background: There are no comparative data on the impact of different empiric antibiotic regimens on early bowel colonization as well as on clinical efficacy in extremely low‐birthweight (ELBW) neonates at risk of early onset sepsis (EOS). Methods: A subgroup analysis was carried out of ELBW neonates recruited into a two‐center, prospective, cluster randomized study comparing ampicillin and penicillin both combined with gentamicin, within the first 72 h of life. A composite primary end‐point (need for change of antibiotics within 72 h and/or 7 day all‐cause mortality) and the rate and duration of colonization by opportunistic aerobic microorganisms were assessed using hierarchical models corrected for study center and period. Results: In the ampicillin (n= 36) and penicillin (n= 39) groups change of antibiotics, 7 day mortality and the composite end‐point occurred at similar rates. Neonatal intensive care unit mortality for infants with gestational age <26 weeks was lower in the ampicillin group. Ampicillin treatment was associated with a higher colonization rate by Klebsiella pneumoniae, including ampicillin‐resistant strains. Conclusion: Preliminary data indicate an urgent need for adequately powered studies of early antibiotic therapy in the subpopulation of ELBW neonates at risk of EOS. 相似文献
10.
Room for improvement in breast milk feeding after very preterm birth in Europe: Results from the EPICE cohort 下载免费PDF全文
Emilija Wilson Anna‐Karin Edstedt Bonamy Mercedes Bonet Liis Toome Carina Rodrigues Elizabeth A. Howell Marina Cuttini Jennifer Zeitlin the EPICE Research Group 《Maternal & child nutrition》2018,14(1)
Breast milk feeding (BMF) is associated with lower neonatal morbidity in the very preterm infant (<32 weeks gestation) and breastfeeding is beneficial for maternal health. Previous studies show large variations in BMF after very preterm birth and recognize the need for targeted breastfeeding support in the neonatal intensive care units (NICU). In a European collaboration project about evidence‐based practices after very preterm birth, we examined the association between maternal, obstetric, and infant clinical factors; neonatal and maternal care unit policies; and BMF at discharge from the NICU. In multivariable analyses, covariates associated with feeding at discharge were first investigated as predictors of any BMF and in further analysis as predictors of exclusive or partial BMF. Overall, 58% (3,826/6,592) of the infants received any BMF at discharge, but there were large variations between regions (range 36–80%). Primiparity, administration of antenatal corticosteroids, first enteral feed <24 hr after birth, and mother's own milk at first enteral feed were predictors positively associated with any BMF at discharge. Vaginal delivery, singleton birth, and receiving mother's own milk at first enteral feed were associated with exclusive BMF at discharge. Units with a Baby Friendly Hospital accreditation improved any BMF at discharge; units with protocols for BMF and units using donor milk had higher rates of exclusive BMF at discharge. This study suggests that there is a high potential for improving BMF through policies and support in the NICU. 相似文献