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排序方式: 共有1002条查询结果,搜索用时 0 毫秒
1.
2.
Balloon dacryocystoplasty: indications and contraindications 总被引:3,自引:0,他引:3
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HM Clink 《Journal of clinical pathology》1980,33(8):799-800
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Semen parameters and testicular pathology in men with testicular cancer and contralateral carcinoma in situ or bilateral testicular malignancies 总被引:2,自引:2,他引:2
Kliesch S; Bergmann M; Hertle L; Nieschlag E; Behre HM 《Human reproduction (Oxford, England)》1997,12(12):2830-2835
We evaluated 14 patients with bilateral testicular tumour, one-sided tumour
and contralateral carcinoma in situ (CIS) of the testis or testis tumour in
single testis with respect to their fertility. We analysed semen
parameters, serum hormones [follicle-stimulating hormone (FSH), luteinizing
hormone (LH) and testosterone], testicular sonography, testicular volumes
and testicular histology prior to further anti-cancer treatment. Ten out of
14 patients showed normal or reduced sperm concentrations, while 4/14
patients were azoospermic. Serum FSH levels showed a significant negative
correlation with sperm concentrations in patients with testicular
malignancies (r = -0.64, P = 0.025). Testicular volumes revealed a
significant positive correlation with semen parameters in patients with
testes that were affected by CIS (r = 0.733, P = 0.038). We conclude that
even bilateral testicular cancer and/or CIS do not preclude fertility and,
therefore, patients should be offered andrological investigation and
therapy, including possibly surveillance strategy or the chance for
cryopreservation of the semen prior to further treatment in order to
preserve their chances for paternity.
相似文献
7.
Survey of CAG/CTG repeats in human cDNAs representing new genes: candidates for inherited neurological disorders 总被引:3,自引:2,他引:3
Neri C; Albanese V; Lebre AS; Holbert S; Saada C; Bougueleret L; Meier-Ewert S; Le Gall I; Millasseau P; Bui H; Giudicelli C; Massart C; Guillou S; Gervy P; Poullier E; Rigault P; Weissenbach J; Lennon G; Chumakov I; Dausset J; Lehrach H; Cohen D; Cann HM 《Human molecular genetics》1996,5(7):1001-1009
8.
P. M. L. A. van den Bemt A. C. G. Egberts A. W. Lenderink J. M. Verzijl K. A. Simons W. S. C. J. M. van der Pol H. G. M. Leufkens 《European journal of clinical pharmacology》1999,55(2):155-158
Objective: This study investigated the relative value of adverse drug events reported by doctors, nurses and patients.
Methods: The study was conducted on a total of four wards: the paediatric and internal medicine wards (including geriatric patients)
of two peripheral hospitals in the Netherlands. Adverse drug events were collected by spontaneous reporting (doctor and nurse
reports) and by daily ward visits, during which the patients were interviewed by a hospital pharmacist (patient reports).
Criteria for relative value of the reported adverse drug events were the number of potentially serious reactions, the number
of reactions not mentioned in the patient information leaflet and the number of reactions reported to new drugs (5 years or
less on the Dutch market). No formal causality assessment was applied.
Results: Over a period of 2 months in 1996 (Hospital I) and 2 months in 1997 (Hospital II) a total of 620 patients were included
in the study and adverse drug events were reported in 179 (29%) of these cases. Doctors reported a statistically significant
larger number of serious (26% of all doctor reports; odds ratio (OR) 3.2; confidence interval (CI) 1.2–8.7) and unknown (39%;
OR 2.5; CI 1.0–6.0) adverse drug events than patients themselves during the daily ward visit. Doctors also reported more serious
and unknown adverse drug events than nurses. Adverse reactions to new drugs were reported during the daily ward visit only
(8% of all daily ward visit reports).
Conclusion: This study reconfirms that doctors are the main source for reports of serious and unknown adverse drug events in hospitalized
patients. However, patients themselves seem to report more adverse reactions to new drugs (during the daily ward visit). By
focusing on patients using new drugs, the daily ward visit might become cost-effective. This needs to be explored in future
studies.
Received: 10 September 1998 / Accepted in revised form: 30 November 1998 相似文献
9.
OBJECTIVES: To determine the spectrum of N and G genotypes of respiratory syncytial virus (RSV) causing respiratory tract infection and whether particular genotypes are associated with severity of infection. PATIENTS AND METHODS: Nasopharyngeal aspirates (NPAs) were obtained from 114 infants with acute respiratory tract infection due to RSV over two seasons. Viral mRNA was extracted from NPAs or cultured virus, reverse transcribed, and the cDNA amplified by the polymerase chain reaction using primers directed to parts of the N and G gene respectively. Amplicons were separately digested with four different restriction endonucleases for each gene. The fragments were separated by agarose gel, electrophoresis, and the electrophoretic patterns used to assign the various genotypes. Disease severity was assessed as very mild (upper respiratory tract signs only), mild (coryza and signs of lower respiratory tract infection), moderate (requiring nasogastric or intravenous fluids), and severe (requiring oxygen or ventilation). RESULTS: Five of the six known N genotypes were detected, but NP4 and NP2 were found most frequently. There was no association between N genotype and disease severity. Six G (SHL) genotypes were detected. Significantly (p = 0.04) more of the infants infected with the SHL2 genotype had severe or moderate disease. CONCLUSIONS: During the seasonal peaks of RSV respiratory tract infection at least 10 different RSV genotypes cocirculated. While there is no association between N genotypes and disease severity, infection with the SHL2 G genotype appears to result in moderate to severe disease. 相似文献
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