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排序方式: 共有182条查询结果,搜索用时 15 毫秒
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Chekhonin VP Lebedev SV Dmitrieva TB Blinov DV Lazarenko IP Savchenko EA Volodin NN 《Bulletin of experimental biology and medicine》2002,133(6):609-613
Cell preparations of ventral mesencephalon obtained from 8-, 14-, and 16-17-day rat embryos were stereotactically transplanted to homologous rats with 6-hydroxydopamine-induced hemiparkinsonism. Automated analysis of apomorphine-induced motor asymmetry for 3 months after neurotransplantation revealed higher efficacy of cell preparations from 8- and lower from 16-17-day-old embryos. These data correlated with histomorphological findigs, in particular, with the size of grafts, glial reaction, and the number of dopaminergic neurons in the grafts. 相似文献
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Among 152 patients with myocardial infarction admitted to a specialized department within a few hours (1st day) of the onset of the disease without cardiac rhythm disorders, or with "minor" arrhythmias, 31 patients were receiving Panangine intravenously, 10--20 ml daily, for 7 days since the moment of admission. Another group of patients was comprised of 75 persons who, in addition to the above regimen of Panangine therapy, received at the moment of their admission a single intramuscular injection of Retabolil (50 mg). The control group was formed by 46 patients receiving no antiarrhythmic drugs. Monitoring of the cardiac rhythm during the acute period of myocardial infarction demonstrated that with preventive employment of Panangine prognostically dangerous rhythm disorders (especially paroxysmal tachycardia) developed less often than in the controls. A combined employment of Panangine and Retabolil resulted in a still better preventive effect, largely preventing, among other developments, the appearance of multiple polytopic extrasystoles. No ventricular fibrillation was observed in the examined patients. 相似文献
5.
Risk factors of the development of phlebothrombosis and thromboembolism of the pulmonary artery (TEPA) were estimated in 257 patients as associated both with the patient and the trauma. The factors influencing the development of risk factors were: bed immobilization, age older than 40, heart failure and respiratory insufficiency, fractures of the lower extremities, skeleton traction, obesity, thrombosis of lower extremities, previous thrombosis or pulmonary embolism, floating clot. Risk factors of the development of vein thrombosis associated with trauma included the presence of lower extremity fractures, skeletal traction or immobilization in bandage, mechanism of injury and type of trauma. 相似文献
6.
Lemonnier L Lazarenko R Shuba Y Thebault S Roudbaraki M Lepage G Prevarskaya N Skryma R 《Endocrine-related cancer》2005,12(2):335-349
Neuroendocrine (NE) differentiation of prostate epithelial/basal cells is a hallmark of advanced, androgen-independent prostate cancer, for which there is no successful therapy. Here we report for the first time on alterations in regulatory volume decrease (RVD) and its key determinant, swelling-activated Cl- current (I(Cl,swell)), associated with NE differentiation of androgen-dependent LNCaP prostate cancer epithelial cells. NE-differentiating regimens, namely, chronic cAMP elevation or androgen deprivation, resulted in generally augmented I(Cl,swell) and enhanced RVD. This occurred as a result of both the increased endogenous expression of ClC-3, which is a volume-sensitive Cl- channel involved, as we show, in I(Cl,swell) in LNCaP (lymph-node carcinoma of the prostate) cells and the weaker negative I(Cl,swell) control from Ca2+ entering via store-dependent pathways. The changes in the RVD of NE-differentiated cells generally mimicked those reported for Bcl-2-conferred apoptotic resistance. Our results suggest that strengthening the mechanism that helps to maintain volume constancy may contribute to better survival rates of apoptosis-resistant NE cells. 相似文献
7.
Lazarenko ON 《Klinichna khirurhiia / Ministerstvo okhorony zdorov'ia Ukra?ny, Naukove tovarystvo khirurhiv Ukra?ny》2004,(1):34-36
One of the probable causes of restenosis occurrence in the stent was analyzed. Experience of surgical treatment of 59 patients with an acute vascular trauma, of the complex cutaneous flaps transplantation and of interventions on lymphovenous system was summarized. There were also conducted experimental investigations in 64 rats and in 54 rabbits, histological preparations of the vessels wall were studied. There was proved that restenosis in the stent may occur due to atrophy of muscular layer of artery, migration and subsequent proliferation of the smooth muscle cells in neointyma after sclerosis of adventitia. It is necessary to use for the stents manufacturing an expansible-dynamical constructions, which promote an active functioning of muscular layer of arterial wall without causing its atrophy. 相似文献
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OP?SanjayEmail author P?Prashanth DI?Tauro 《Indian Journal of Thoracic and Cardiovascular Surgery》2003,19(3):141-144
Background Post thoractomy pain is a major source of concern in the postoperative period. The purpose of this study was to evaluate the
effectiveness of intraoperative temporary intercostal nerve blockade versus thoracic epidural analgesia for control of post
thoracotomy pain.
Methods 40 patients undergoing elective pulmonary resection through a postero lateral thoractomy were randomly allocated to receive
epidural analgesia using 0.25% bupivicaine (Group A, n=20) or temporary intercostal nerve blockade using 0.25% bupivicaine
(Group B, n=20). Adequacy of analgesia was assessed over a period of 24 hours using a visual analogue score and an observer
verbal ranking scale.
Results Pain scores were similar in both the groups for the first 4 hours after surgery. Thereafter, the pain scores were significantly
higher (p<0.05) in Group B as compared to Group A for the remainder of the observation period. There was significantly higher
(p<0.01) usage, of nonsteroidal analgesic consumption in Group B. No neurological complications were encountered, in both
the study groups.
Conclusion We conclude that in the early postoperative period there is no significant difference in pain relief in both the techniques
but there after, epidural analgesia significantly reduces post thoracotomy pain. 相似文献
10.
OP?SanjayEmail author VR?Kadam J?Menezes P?Prashanth DI?Tauro 《Indian Journal of Thoracic and Cardiovascular Surgery》2003,19(2):113-118
Background: Optimum pain relief following thoracotomy is essential for patient comfort and to reduce the incidence of postoperative pulmonary
complications.
Methods: A randomized clinical trial was conducted on 90 patients scheduled for pulmonary resection. The patients were randomly divided
into three groups. Group 1 received 0.125% bupivicaine with fentanyl 10μg.ml−1, Group 2 received 0.25% bupivicaine with fentanyl 10μg.ml−1 and Group 3 received only fentanyl 10μg.ml−1 in a calculated dose as a continuous thoracic epidural infusion. Adequacy of anglesia was assessed at rest and during movement
over 24 hours. Analgesic efficacy was assessed using a visual analogue score and an observer verbal ranking scale.
Results: Pain scores were significantly higher in Group 3 during the assessment period. (p<0.01) as compared to the other groups.
The use of intraoperative vasopressors was significantly higher (p<0.05) in Group 2 as compared to the other groups. No neurological
complications were encountered in any of the study groups.
Conclusion: We conclude that in the early postoperative period, the use of 0.125% bupivicaine improves fentanyl epidural analgesia in
patients undergoing lung resection. 相似文献