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1.
J A Vazquez G A Paleos H J Steinhardt K Langer M Brandl W L Fekl S A Adibi 《The American journal of clinical nutrition》1986,44(1):24-32
We investigated parameters of nutrition, metabolism, and organ function after 4 wk of total parenteral nutrition (TPN) in baboons receiving either dipeptides or amino acids as the nitrogen source. The two groups showed no significant difference with respect to gain in body weight, nitrogen balance, plasma and muscle concentrations of amino acids, plasma concentrations of proteins, and leucine incorporation into muscle protein. All dipeptides were efficiently utilized as evidenced by trace concentrations of dipeptides in plasma and urine; they produced no deleterious effect on the function of liver, kidney, or immune system. Development of infection in several baboons increased urinary excretion of urea nitrogen but had no effect on urinary excretion of dipeptides and amino acids with the single exception of taurine, which was greatly increased. In conclusion, the data show long-term efficacy and safety of the dipeptide mixture as the sole nitrogen source for TPN. 相似文献
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Bagher Larijani Mir Reza Bekheirnia Akbar Soltani Alireza Khalili‐Far Hossein Adibi Reza Baradar Jalili 《American journal of human biology》2004,16(2):168-171
The aim of this study was to determine the relationships between bone mineral density (BMD) and blood pressure in 214 men, age 20–76. BMD measurements were done by dual X‐ray absorptiometry using a Lunar DPXMD densitometer at the lumbar spine (L2–L4) and different femoral regions. Systolic (SBP) and diastolic (DBP) blood pressure were measured using an MPC‐350 sphygmomanometer. Physicians gathered demographic data and participants' dietary intake of calcium were determined by using food frequency questionnaires. After adjusting for age, body mass index, dietary calcium, and exercise history, multiple linear regression models showed that DBP was negatively related to femoral neck BMD (β = ?0.145, P = 0.032) and just shy of significant association with femoral neck BMC (β = ?0.114, P = 0.079). SBP was correlated with femoral neck (r = ?0.171, P = 0.012) and Ward's (r = ?0.186, P = 0.006) BMD but not after adjusting for possible confounders. Further studies are needed to determine whether elevated blood pressure is causally related to the development of low bone mass. Am. J. Hum. Biol. 16:168–171, 2004. © 2004 Wiley‐Liss, Inc. 相似文献
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Regulation of hepatocyte activator inhibitor-1 expression by androgen and oncogenic transformation in the prostate 下载免费PDF全文
Knudsen BS Lucas JM Fazli L Hawley S Falcon S Coleman IM Martin DB Xu C True LD Gleave ME Nelson PS Ayala GE 《The American journal of pathology》2005,167(1):255-266
Hepatocyte activator inhibitor-1 (HAI-1) is a transmembrane serine protease inhibitor that regulates the conversion of latent to active hepatocyte growth factor (HGF). Studies supporting a role for the HGF pathway in prostate carcinogenesis prompted an analysis of HAI-1 expression in the prostate. Here we analyze the regulation of HAI-1 expression by androgen, oncogenic transformation, and cancer progression. Immunohistochemical analysis revealed that HAI-1 expression was restricted to prostate epithelium, where staining occurred primarily in basal and atrophic luminal epithelial cells. Compared to normal glands, HAI-1 expression was significantly increased in localized prostate cancer and was present in most prostate cancer metastases. HAI-1 protein expression levels were sensitive to androgen in normal epithelium but not in cancer. Although androgen did not increase HAI-1 protein expression levels in LNCaP cells, it decreased HAI-1 surface expression, consistent with previous data from our group (Martin DB, Gifford DR, Wright ME, Keller A, Yi E, Goodlett DR, Aebersold R, Nelson PS: Quantitative proteomic analysis of proteins released by neoplastic prostate epithelium. Cancer Res 2004, 64:347-355). HAI-1 overexpression in cancer was predictive of prostate-specific antigen recurrence (relative risk, 1.24). These results suggest that HAI-1 regulates the HGF Met axis on prostate epithelial cells and influences HGF mediated tumor invasion and metastasis. 相似文献
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Carol Dawson-Rose PhD Deena Shehadeh MSN RN-BC PHN Jennifer Hao BA Jasmine Barnard BA Ladan Khoddam-Khorasani MPH Adam Leonard MS MPH CPNP AAHIVS Kristen Clark MSN RN Eva Kersey BA Haley Mousseau MA Julie Frank LCSW MSW Aaron Miller PMHNP Adam Carrico PhD Amy Schustack EdD Yvette P. Cuca PhD 《Public health nursing (Boston, Mass.)》2020,37(3):363-370
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Ladan Mohajeri Farnaz Salehi Payman Mehrvarzfar Hamide Arfaee Behnam Bohluli Reza Hamedy 《Anesthesia progress》2015,62(1):14-19
Achieving adequate pulpal anesthesia in mandibular teeth is always a challenge. Supplementary injections and using drugs in combination are some methods implemented to overcome this hurdle. In this randomized clinical trial, use of meperidine in conjunction with lidocaine in intraligamentary injection did not exhibit significant improvement in anesthesia.Key Words: Periodontal ligament, Meperidine, Irreversible pulpitis, Dental anesthesiaThe failure rate of the inferior alveolar nerve block (IANB) in some experimental studies has been reported up to 75%.1–4 This lack of success has even increased to a maximum of 81% in some recent studies.5–7 To overcome this shortcoming, dental clinicians have actively sought measures to improve the patients'' anesthesia during different dental procedures. Apart from the anatomical variations mentioned in the applied anatomy of injections,8 several authors have attempted to modify the anesthetic technique,9–12 and others have compared different anesthetic agents13 or their concentrations14 to improve their efficacy.Activating the opioid receptors peripherally in inflammatory conditions has become a new trend in research to manage postoperative pain.15 Synergy between local anesthetics and opioids has become an interesting field of research recently.16 Opioids are frequently added to local anesthetics in a variety of surgical procedures, eg, intrathecal application for minor surgery.17 Meperidine or its derivatives, eg, pethidine (meperidine chloride) or norpethidine (Pethidine Intermediate B) are agonists of μ-opioid receptors, which block the pathway of pain signals to the trigeminal nucleus. They also activate peripheral opioid receptors and block sodium channels.17–22 Despite controversy regarding the use of meperidine as an anesthetic,22 recent studies have demonstrated its benefits over prilocaine in arthroscopy with local anesthesia,16 nasal packing removal,23 etc.However, only a few studies have investigated the dental anesthetic efficacy of such combinations.24,25 The effect of the addition of meperidine to lidocaine in IANB for pain management in normal teeth24 and also in teeth with irreversible pulpitis25 has been studied. The aim of our study was to compare the efficacy of local anesthetics with and without meperidine for intraligamentary supplemental injection for teeth with irreversible pulpitis. Our null hypothesis stated that the addition of meperidine to standard lidocaine with epinephrine does not improve the efficacy of supplemental intraligamentary anesthesia in teeth with symptomatic irreversible pulpitis. The specific objectives were to randomly allocate volunteers with complete soft tissue anesthesia following an IANB, yet having positive pulp response, into 2 groups, and then compare the efficacy of lidocaine with epinephrine plus meperidine with that of lidocaine with epinephrine plus an equal volume of sterile water for supplemental periodontal ligament anesthesia. 相似文献
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Musa Ibrahim Adamu Ladan Mu’azu Nura Idris Musa Uba Rabiu Binta Wudil Jibir Kabir Ibrahim Getso Mohammad Aminu Mohammad Femi Luqman Owolabi 《African Journal of Paediatric Surgery》2015,12(1):23-28