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排序方式: 共有178条查询结果,搜索用时 15 毫秒
1.
Coprological examination of 40 Apodemus mystacinus Danford and Alston 1877 from Jordan revealed oocysts of three species of genus Eimeria. Two species are described as new. Eimeria zuhairamri sp. n. has broadly ellipsoidal oocysts 29.6 (27.0–34.0)×23.3 (22.0–25.0) m with distinctly granulated wall and oocyst residuum. Endogenous development occurs in jejunum and ileum. Eimeria alorani sp. n. has oocysts 26.9 (23.0–29.0)×19.3 (18.0–22.0) m with smooth wall and absent residuum. Endogenous development is confined to the caecum. The third species, developing in jejunum, has oocysts morphologically indistinguishable from Eimeria uptoni. The identity of E. uptoni and the taxonomy of Eimeria of Apodemus are discussed. 相似文献
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James Larkin Michele Del Vecchio Paolo A Ascierto Ivana Krajsova Jacob Schachter Bart Neyns Enrique Espinosa Claus Garbe Vanna Chiarion Sileni Helen Gogas Wilson H Miller Mario Mandalà Geke A P Hospers Ana Arance Paola Queirolo Axel Hauschild Michael P Brown Lada Mitchell Christian U Blank 《The lancet oncology》2014,15(4):436-444
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Bozhkov PV Suarez MF Filonova LH Daniel G Zamyatnin AA Rodriguez-Nieto S Zhivotovsky B Smertenko A 《Proceedings of the National Academy of Sciences of the United States of America》2005,102(40):14463-14468
Programmed cell death (PCD) is indispensable for eukaryotic development. In animals, PCD is executed by the caspase family of cysteine proteases. Plants do not have close homologues of caspases but possess a phylogenetically distant family of cysteine proteases named metacaspases. The cellular function of metacaspases in PCD is unknown. Here we show that during plant embryogenesis, metacaspase mcII-Pa translocates from the cytoplasm to nuclei in terminally differentiated cells that are destined for elimination, where it colocalizes with the nuclear pore complex and chromatin, causing nuclear envelope disassembly and DNA fragmentation. The cell-death function of mcII-Pa relies on its cysteine-dependent arginine-specific proteolytic activity. Accordingly, mutation of catalytic cysteine abrogates the proteolytic activity of mcII-Pa and blocks nuclear degradation. These results establish metacaspase as an executioner of PCD during embryo patterning and provide a functional link between PCD and embryogenesis in plants. Although mcII-Pa and metazoan caspases have different substrate specificity, they serve a common function during development, demonstrating the evolutionary parallelism of PCD pathways in plants and animals. 相似文献
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Cytogenetic analysis of the X chromosome in phytohaemagglutinin stimulated peripheral blood lymphocytes was evaluated in 12 sporadic Alzheimer disease (AD) patients and in 11 healthy subjects. For chromosome analysis two methods were used: (1) standard analysis of G-banded metaphase chromosomes and; (2) fluorescent in situ hybridization (FISH) for the detection of the X chromosome centromeric region in interphase nuclei. Cytogenetic analysis revealed that the X chromosome expresses premature centromere division (PCD) in AD females in 10.53% of metaphase cells and in 15.22% of interphase nuclei. In AD men the percentages were 3.98 and 6.06%, respectively. X chromosome PCD in the female control group showed a percentage of 7.46% in metaphase cells and 9.35% in interphase nuclei and in male controls the percentages were 2.84% in metaphases and 5.54% in interphase nuclei. The results of FISH analysis showed that PCD could occur much earlier than metaphase of mitosis, i.e. in interphase of the cell cycle, immediately after replication. The FISH method can be used for PCD verification in all phases of the cell cycle in various disorders including AD. 相似文献
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Stefan Arsov Lada Trajceska Wim van Oeveren Andries J. Smit Pavlina Dzekova Bernd Stegmayr Aleksandar Sikole Gerhard Rakhorst Reindert Graaff 《Artificial organs》2013,37(7):E114-E122
Advanced glycation end‐products (AGEs) are uremic toxins that accumulate progressively in hemodialysis (HD) patients. The aim of this study was to assess the 1‐year increase in skin autofluorescence (ΔAF), a measure of AGEs accumulation and plasma markers, as predictors of mortality in HD patients. One hundred sixty‐nine HD patients were enrolled in this study. Skin autofluorescence was measured twice, 1 year apart using an AGE Reader (DiagnOptics Technologies BV, Groningen, The Netherlands). Besides routine blood chemistry, additional plasma markers including superoxide dismutase, myeloperoxydase, intercellular adhesion molecule 1 (ICAM‐1), C‐reactive protein (hs‐CRP), heart‐type fatty acid binding protein (H‐FABP), and von Willebrand factor were measured at baseline. The mortality of HD patients was followed for 36 months. Skin autofluorescence values of the HD patients at the two time points were significantly higher (P < 0.001) than those of healthy subjects of the same age. Mean 1‐year ΔAF of HD patients was 0.16 ± 0.06, which was around seven‐ to ninefold higher than 1‐year ΔAF in healthy subjects. Multivariate Cox regression showed that age, hypertension, 1‐year ΔAF, hs‐CRP, ICAM‐1, and H‐FABP were independent predictors of overall mortality. Hypertension, 1‐year ΔAF, hs‐CRP, and H‐FABP were also independent predictors of cardiovascular mortality. One‐year ΔAF and plasma H‐FABP, used separately and in combination, are strong predictors of overall and cardiovascular mortality in HD patients. 相似文献
8.
Elena E. Ushakova Artem V. Sergeev Artem Morzhukhin Filipp S. Napolskiy Olga Kristavchuk Alexander V. Chertovich Lada V. Yashina Daniil M. Itkis 《RSC advances》2020,10(27):16118
Solid electrolytes are of high interest for the development of advanced electrochemical energy storage devices with all-solid-state architectures. Here, we report the fabrication of the electrolyte membranes based on LiTFSI (LiN(CF3SO2)2) and PEO–PVDF blends with improved properties. We show that addition of PVDF enables preparation of free-standing films of the compositions within the so called “crystallinity gap” of the LiTFSI–PEO system known to provide high ion conductivity. We show that optimal PVDF content enables preparation of the films with reasonable elastic modulus and high ionic conductivity of about 0.3 mS cm−1 at 60 °C and about 0.1 mS cm−1 at room-temperature. Combining FTIR spectroscopy, XRD and DSC measurements we show that a noticeable fraction of PVDF remains crystalline and enhances the mechanical properties of the material, and at the same time it additionally promotes LiTFSI dissociation and disordering. Density functional theory calculations showed that the Li+–PEO–PVDF complexation energy magnitude is almost as high as that of Li–PEO complexes, thus the salt dissociation ability can be retained in spite of the introduction of the substantial amounts of PVDF required for mechanical stability.Addition of PVDF to LiTFSI–PEO solid electrolytes enables preparation of free-standing films with the compositions within the so called “crystallinity gap” of LiTFSI–PEO system. Such films possess ionic conductivity of about 0.3 mS cm−1 at 60 °C. 相似文献
9.
Vidar O. Edvardsson David S. Goldfarb John C. Lieske Lada Beara-Lasic Franca Anglani Dawn S. Milliner Runolfur Palsson 《Pediatric nephrology (Berlin, Germany)》2013,28(10):1923-1942
Adenine phosphoribosyltransferase (APRT) deficiency, cystinuria, Dent disease, familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC), and primary hyperoxaluria (PH) are rare but important causes of severe kidney stone disease and/or chronic kidney disease in children. Recurrent kidney stone disease and nephrocalcinosis, particularly in pre-pubertal children, should alert the physician to the possibility of an inborn error of metabolism as the underlying cause. Unfortunately, the lack of recognition and knowledge of the five disorders has frequently resulted in an unacceptable delay in diagnosis and treatment, sometimes with grave consequences. A high index of suspicion coupled with early diagnosis may reduce or even prevent the serious long-term complications of these diseases. In this paper, we review the epidemiology, clinical features, diagnosis, treatment, and outcome of patients with APRT deficiency, cystinuria, Dent disease, FHHNC, and PH, with an emphasis on childhood manifestations. 相似文献