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SLJIVIC B BOSKOVIC M SAVIC V 《Acta medica Iugoslavica》1957,11(1-2):169-77; Serbo-Croatian summary 177-9
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IGOR MRDOVIC M.D. Ph .D LIDIJA SAVIC M.D. JOVAN PERUNICIC M.D. Ph .D. MILIKA ASANIN M.D. RATKO LASICA M.D. Ph .D. JELENA MARINKOVIC Ph .D. ZORANA VASILJEVIC M.D. Ph .D. MIODRAG OSTOJIC M.D. Ph .D. F.E.S.C. F.A.C.C. 《Journal of interventional cardiology》2009,22(4):320-328
Background: No comprehensive primary PCI (pPCI) risk model to predict net adverse cardiovascular events (NACE) has been reported with the use of clopidogrel 600 mg, which is now considered the standard loading dose. The primary hypothesis of the RISK-PCI trial is that an accurate risk prediction may be achieved by using clinical, angiographic, and procedural variables available at the time of intervention.
Methods: The present single-center, longitudinal, cohort study will include 1,750 consecutive patients with ST-elevation myocardial infarction (STEMI), undergoing pPCI after pretreatment with 300 mg aspirin and 600 mg clopidogrel. The primary end-points of the trial (NACE) include major adverse cardiovascular events (MACE) and major bleeding. A logistic regression model will be developed to predict 30-day and 1-year NACE after pPCI. A risk score derived from study set data will be validated using validation set data.
Results: Until June 1, 2008, 1,166 patients have been enrolled. Thirty-day follow-up is available in 1,007 patients.
Conclusions: The RISK-PCI study is designed to develop an accurate risk scoring system, using variables available at the time of intervention, to predict long-term adverse outcomes after pPCI.
Trial Registration: Current Controlled Trials Register—ISRCTN83474650— http://www.controlled-trials.com/ISRCTN83474650) . 相似文献
Methods: The present single-center, longitudinal, cohort study will include 1,750 consecutive patients with ST-elevation myocardial infarction (STEMI), undergoing pPCI after pretreatment with 300 mg aspirin and 600 mg clopidogrel. The primary end-points of the trial (NACE) include major adverse cardiovascular events (MACE) and major bleeding. A logistic regression model will be developed to predict 30-day and 1-year NACE after pPCI. A risk score derived from study set data will be validated using validation set data.
Results: Until June 1, 2008, 1,166 patients have been enrolled. Thirty-day follow-up is available in 1,007 patients.
Conclusions: The RISK-PCI study is designed to develop an accurate risk scoring system, using variables available at the time of intervention, to predict long-term adverse outcomes after pPCI.
Trial Registration: Current Controlled Trials Register—ISRCTN83474650— http://www.controlled-trials.com/ISRCTN83474650) . 相似文献
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