全文获取类型
收费全文 | 1363篇 |
免费 | 60篇 |
国内免费 | 26篇 |
专业分类
耳鼻咽喉 | 16篇 |
儿科学 | 68篇 |
妇产科学 | 48篇 |
基础医学 | 87篇 |
口腔科学 | 14篇 |
临床医学 | 190篇 |
内科学 | 316篇 |
皮肤病学 | 124篇 |
神经病学 | 21篇 |
特种医学 | 19篇 |
外科学 | 156篇 |
综合类 | 77篇 |
一般理论 | 4篇 |
预防医学 | 76篇 |
眼科学 | 21篇 |
药学 | 136篇 |
中国医学 | 24篇 |
肿瘤学 | 52篇 |
出版年
2017年 | 11篇 |
2015年 | 15篇 |
2014年 | 22篇 |
2013年 | 30篇 |
2012年 | 16篇 |
2011年 | 17篇 |
2010年 | 52篇 |
2009年 | 48篇 |
2008年 | 27篇 |
2007年 | 36篇 |
2006年 | 44篇 |
2005年 | 24篇 |
2004年 | 14篇 |
2003年 | 18篇 |
2002年 | 16篇 |
2001年 | 13篇 |
1999年 | 15篇 |
1998年 | 33篇 |
1997年 | 53篇 |
1996年 | 59篇 |
1995年 | 34篇 |
1994年 | 54篇 |
1993年 | 33篇 |
1992年 | 28篇 |
1991年 | 29篇 |
1990年 | 27篇 |
1989年 | 22篇 |
1988年 | 28篇 |
1987年 | 34篇 |
1986年 | 24篇 |
1985年 | 25篇 |
1984年 | 34篇 |
1983年 | 21篇 |
1982年 | 25篇 |
1981年 | 17篇 |
1980年 | 11篇 |
1979年 | 26篇 |
1978年 | 13篇 |
1977年 | 8篇 |
1976年 | 17篇 |
1969年 | 13篇 |
1964年 | 10篇 |
1959年 | 28篇 |
1958年 | 35篇 |
1957年 | 36篇 |
1956年 | 29篇 |
1955年 | 34篇 |
1954年 | 27篇 |
1949年 | 21篇 |
1948年 | 23篇 |
排序方式: 共有1449条查询结果,搜索用时 15 毫秒
1.
JANE P. F. BAI HAE-JIN HONG DAVID A. ROTH ENBERGER W. DOUGLAS WONG JOHN G. BULS 《The Journal of pharmacy and pharmacology》1996,48(11):1180-1184
The aim of this research is to characterize the presence of insulin-degrading enzyme in human colon and ileal mucosal cells. Biochemical studies, including the activity-pH profiles, the effects of enzyme inhibitors, immunoprecipitation and western blots, were conducted. The majority of insulin-degrading activity in colon mucosal cells was localized in the cytosol. In both colon and ileum, cytosolic insulin-degrading activities had a pH optimum at pH 7.5, and were extensively inhibited by each of N-ethylmaleimide, p-chloromercuribenzoate, and 1,10-phenanthroline, but were very weakly affected by each of leupeptin, chymostatin, diisopropyl phosphofluoridate and soybean trypsin inhibitor. In the colon and ileum, more than 93% and 96%, respectively, of cytosolic insulin-degrading activities were removed by the mouse monoclonal antibody to human RBC insulin-degrading enzyme, as compared with less than 20% by the normal mouse IgG for both tissues. Further, a western blot analysis revealed that a cytosolic protein of 110 kD, in both human colon and ileum, reacted with the monoclonal antibody to insulin-degrading enzyme. It is concluded that insulin-degrading enzyme is present in the cytosol of human colon and ileal mucosal cells. 相似文献
2.
Anthony BOERS Qiang LI Melinda WONG Marian MILLER Geoff LITTLEJOHN 《International journal of rheumatic diseases》2006,9(1):43-48
Aim: We performed a semiprospective and retrospective review of all admissions to a single institution of systemic lupus erythematosus (SLE) patients, admitted due to active disease. The aim was to describe differences in disease activity as a cause of hospital admissions between patients originating from South‐East Asia/China (SAC) and Caucasians. Method: There were 210 patients admitted for active disease, with a total of 567 admissions for active SLE over a 16‐year period. Allowing for patients who had left our database, there was a total of 3415 patient years of observation. Results: Patients from SAC with a flare requiring admission presented earlier in their disease course and with more active disease than did Caucasians (median SLE Disease Activity Index 13 vs. 8, P= 0.002). They had longer inpatient stays (7 vs. 5 days P = 0.03). There was a trend to higher rates of re‐presentation to hospital for flare (59% in SAC patients vs. 41% in Caucasians, P = 0.09) with more subsequent admissions (3 vs. 2 P = 0.06) despite a shorter period of observation. Conclusions: South‐East Asian/Chinese were more likely to be diagnosed with class III/IV glomerulonephritis and require cyclophosphamide both at presentation and subsequent admissions. More patients from SAC were readmitted to hospital for severe central nervous system disease after their first hospital admission. In this population, lupus patients had more severe flares and more frequently required admission for these than Caucasians. 相似文献
3.
4.
5.
Trisomy 8 in acute promyelocytic leukaemia: an interphase study by fluorescence in situ hybridization 总被引:1,自引:0,他引:1
Summary. Acute promyelocytic leukaemia (APL) is characterized by t(15;17)(q24;q21). Trisomy 8 is the commonest accompanying karyotypic aberration. We investigated 14 APL patients for trisomy 8 using fluorescence in situ hybridization (FISH). Conventional cytogenetic analysis showed trisomy 8 in two of nine successfully karyotyped cases. With FISH, a possible third case showing a subclone (1-2-5%) with trisomy 8 was found. The trisomy 8 clone size defined by karyotyping and FISH was concordant in one case and discordant in another, in which trisomy 8 was found in 100% of metaphases but only in 48% of leukaemic prbmyelocytes by FISH. Therefore trisomy 8 was mosaic in all the cases, suggesting that it had arisen from clonal evolution. AU-trans-retinoic acid successfully induced morphologic remission in both cases with trisomy 8. 相似文献
6.
7.
8.
M. WATSON S. LAWRENCE A. COLLINS R. BEASLEY I. DOULL B. BEGISHVILI F. LAMPE S. T. HOLGATE N. E. MORTON 《Annals of human genetics》1995,59(4):403-411
We have typed three markers on proximal 11q in 131 random families with three or more children studied for atopy. A summary map that includes the FCER1B candidate was constructed. Using a 2-locus disease model, we performed combined segregation and linkage analysis of three models, none of which suggested linkage. Nine marker loci on other chromosomes were also negative. In the regions swept by these 12 markers we cannot rule out a rare gene, perhaps of large effect, nor a common gene of small effect. However, a common gene of large effect is excluded. These results and alternative strategies are discussed in the perspective of inconsistent evidence for a major atopy gene. 相似文献
9.
10.