全文获取类型
收费全文 | 1156篇 |
免费 | 55篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 45篇 |
儿科学 | 13篇 |
妇产科学 | 6篇 |
基础医学 | 128篇 |
口腔科学 | 8篇 |
临床医学 | 62篇 |
内科学 | 203篇 |
皮肤病学 | 27篇 |
神经病学 | 122篇 |
特种医学 | 48篇 |
外科学 | 275篇 |
综合类 | 3篇 |
预防医学 | 44篇 |
眼科学 | 7篇 |
药学 | 77篇 |
中国医学 | 7篇 |
肿瘤学 | 140篇 |
出版年
2023年 | 9篇 |
2022年 | 19篇 |
2021年 | 28篇 |
2020年 | 12篇 |
2019年 | 17篇 |
2018年 | 14篇 |
2017年 | 16篇 |
2016年 | 14篇 |
2015年 | 15篇 |
2014年 | 14篇 |
2013年 | 22篇 |
2012年 | 39篇 |
2011年 | 65篇 |
2010年 | 21篇 |
2009年 | 27篇 |
2008年 | 45篇 |
2007年 | 61篇 |
2006年 | 46篇 |
2005年 | 43篇 |
2004年 | 48篇 |
2003年 | 63篇 |
2002年 | 65篇 |
2001年 | 41篇 |
2000年 | 36篇 |
1999年 | 30篇 |
1998年 | 21篇 |
1997年 | 23篇 |
1996年 | 15篇 |
1995年 | 14篇 |
1994年 | 20篇 |
1993年 | 8篇 |
1992年 | 24篇 |
1991年 | 36篇 |
1990年 | 23篇 |
1989年 | 22篇 |
1988年 | 22篇 |
1987年 | 16篇 |
1986年 | 38篇 |
1985年 | 16篇 |
1984年 | 13篇 |
1983年 | 10篇 |
1982年 | 7篇 |
1981年 | 5篇 |
1980年 | 6篇 |
1979年 | 13篇 |
1978年 | 6篇 |
1977年 | 6篇 |
1976年 | 7篇 |
1974年 | 7篇 |
1968年 | 5篇 |
排序方式: 共有1215条查询结果,搜索用时 15 毫秒
1.
Kazumichi Yamada Satoshi Goto Taro Oyama Makoto Yoshikawa Shinji Nagahiro Yukitaka Ushio 《Acta neuropathologica》1995,89(2):172-177
The present study concerns the vulnerability of striatal interneurons immunopositive for the Ca2+-binding protein calretinin to ischemic neuronal injury. An immunohistochemical study was carried out on the striata of rats which had undergone transient middle cerebral artery occlusion. Two weeks after the ischemia, there was a marked reduction in the number of calretinin-positive neurons in the ipsilateral ischemic lesion, although the striatal interneurons positive for parvalbumin, which are a neuronal population distinct from the calretinin-immunoreactive cells in the striatum, were spared in the insulted areas. The present data indicate that the striatal calretinin-positive neurons are less resistant to transient ischemia, suggesting that there may exist vulnerability differences among the striatal interneurons in ischemia-induced neuronal injury. 相似文献
2.
This is the second reported case of a malignant fibrous histiocytoma of the heart that metastasized to the brain. A 33-year-old woman developed headache, nausea, and ataxic gait 9 months after removal of the tumor from the left atrium of the heart. Computed tomographic and magnetic resonance imaging scans disclosed multiple metastatic tumors in the brain. Although dramatic improvement in her symptoms and signs followed the removal of the brain tumors, she died of tumor recurrence in the left atrium 3 months after the removal of the metastatic brain tumors. 相似文献
3.
K Moroki J Kuratsu S Yoshioka M Kohchi S Uemura Y Matsukado Y Ushio 《Brain and nerve》1989,41(3):305-307
We examined the level of sialic acid in cerebrospinal fluid (CSF) in 20 patients with brain tumor, and 5 patients with non-neoplastic disease of central nervous system. CSF concentration of sialic acid in the patients with malignant and semi-malignant or benign brain tumor was 5.26 +/- 2.39 mg/dl, and 1.82 +/- 1.61 mg/dl, respectively. In patients with non-neoplastic disease, it was 1.64 +/- 1.53 mg/dl. The difference between groups was statistically significant (p less than 0.005). In two patients with malignant brain tumor, the level of sialic acid was decreased by radiation therapy or intrathecal chemotherapy. In conclusion, CSF concentration of sialic acid was significant of diagnosis of brain tumor character of malignancy, and effect of therapy for CSF dissemination. 相似文献
4.
E Kumura N Arita T Hayakawa Y Ushio H Nakata A Murasawa H Mogami J Ikezoe Y Minami 《Neurosurgery》1986,18(6):802-804
We found combination chemotherapy with cisplatinum, vinblastine, and bleomycin (PVB therapy) effective in the treatment of a patient with a pineal germ cell tumor with peritoneal dissemination. The metastatic complication may have been attributable to the ventriculoperitoneal shunt tube. After the first course of PVB therapy, the disseminated tumors were decreased in size; no residual tumors were detected after the third course by laparoscopic examination, computed tomographic scanning, or echogram. Our results suggest that combined PVB therapy is effective in the treatment of extraneural metastasis from intracranial germ cell tumors. 相似文献
5.
Improved high performance liquid chromatography determination of hippuric acid and methylhippuric acid isomers in urine 总被引:1,自引:0,他引:1
Y Takeuchi T Sakai Y Ikeya T Araki K Ushio S Yanagihara 《Sangyō igaku. Japanese journal of industrial health》1986,28(6):455-461
A study was made on the effect of detection wavelength and separation mode of HPLC on determination of urinary hippuric acid (HA) and three isomers of methylhippuric acid (MHA). The interference of other constituents of urine in the determination was effectively decreased by detection at a short wavelength of 227.6 nm. Meta and para MHAs were separated by the addition of beta-cyclodextrine to the mobile phase. Four metabolites were successfully separated from other components of urine by the combination of ODS-silica packed-column and mobile phase (method F). The detection limits were found to be 50 and 5 mg/l for HA and MHAs, respectively. MHAs could not be detected in the non-exposed subjects. Average levels (+/- SD) of HA in non-exposed males and females were 272.2 (+/- 210.8) and 393.0 (+/- 269.8) mg/l, respectively. The urinary levels of HA in females were significantly higher than those in males. 相似文献
6.
K Yamada Y Ushio T Hayakawa N Arita T Y Huang M Nagatani N Yamada H Mogami 《Cancer research》1987,47(8):2123-2128
To assess the rationale of intraarterial (i.a.) 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea chemotherapy, distribution of 14C-labeled 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)- 3-nitrosourea in rat glioma was studied after i.a. or i.v. infusion. Immediately after infusion, the tumor located in the hemisphere of intracarotid infusion received 4.6-fold higher radioactivity than the tumor located contralaterally to intracarotid infusion and 2.8-fold higher radioactivity than i.v. infusion. The difference was kept up to 30 min after i.a. infusion. Autoradiographic observation indicated rather uniform distribution of the tracer in the central portion of i.a. infusion. However, in the periphery of i.a. infusion, distribution of the tracer was nonhomogenous. The results indicate that i.a. 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea chemotherapy is useful when the tumor has high blood flow and is located in the center of an infused area. 相似文献
7.
Mitsuhiro Morita Harumoto Yamada Osamu Hemmi Kyosuke Fujikawa 《Journal of orthopaedic science》2004,9(1):99-102
In acetabular dysplasia of the hip joint accompanied by a giant acetabular bone cyst, rotational acetabular osteotomy may cause serious complications, such as bone necrosis after surgery or fracture of the fragile acetabulum during the operation. In a patient with this condition, we performed a two-stage operation: first, autogenous bone grafting supplemented with hydroxyapatite filling, then rotational acetabular osteotomy (after new bone formation had been assured). Radiographs and CT scans showed favorable fusion of the grafted bone. Some 18 months after the second operation, arthrograms showed no inflow of contrast medium from the articular cavity into the bone cyst region, although this had been observed before treatment. Thus, an effective remodeling of bony congruency was indicated in the mobile acetabulum 5 years after the second operation. This two-stage operation appears to be useful for correcting acetabular dysplasia accompanied by a giant bone cyst and to carry a reduced risk of serious complications, such as deterioration of the articular surface of the acetabulum or necrosis of the translocated acetabulum. 相似文献
8.
Intracranial arterial vasospasm associated with pituitary apoplexy after head trauma--case report. 总被引:3,自引:0,他引:3
Y Itoyama S Goto M Miura J Kuratsu Y Ushio T Matsumoto 《Neurologia medico-chirurgica》1990,30(5):350-353
A case of intracranial arterial vasospasm caused by pituitary apoplexy after head trauma is reported. In this case, pituitary apoplexy was secondary to head trauma, and the vasospasm was thought to be due to subarachnoid hemorrhage from a pituitary tumor. No such case has previously been reported in the literature. 相似文献
9.
PURPOSETo determine whether steady-state free precession sequences improve the MR visibility of epidermoid tumors in comparison with spin-echo images.METHODSPatients were four women and three men with epidermoid tumors in the subarachnoid spaces. MR was performed with a 1.5-T superconductive unit. For steady-state free precession imaging, three-dimensional Fourier transform fast imaging with steady-state free precession (FISP) images were used (20-40/7 [repetition time/echo time], flip angle of 25 degrees). The visualization and contrast-to-noise ratio were compared in FISP images and spin-echo images. In one case, the images of FISP and fast low-angle shot were obtained with variable repetition times and flip angles to evaluate the best pulse sequences for the visualization of epidermoid tumors.RESULTSThe contrast-to-noise ratios between tumors and cerebrospinal fluid ranged from 7.9 to 17.5 (average was 12.9) on FISP images. The average of contrast-to-noise ratios on T1, T2, and proton density-weighted spin-echo images were 1.6, 2.0, and 4.2, respectively. Three-dimensional Fourier transform FISP images best showed central nervous system and demonstrated epidermoid tumors excellently.CONCLUSIONSEpidermoid tumors in the subarachnoid spaces were better demonstrated on steady-state free precession (three-dimensional Fourier transform FISP) than on conventional spin-echo images. 相似文献
10.