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排序方式: 共有37条查询结果,搜索用时 31 毫秒
1.
Patrick M. Rao M.D. A. John Kuta M.D. Michele H. Johnson M.D. 《Emergency radiology》1995,2(5):303-304
We present a case in which an open fracture of the ulna penetrated the skull and caused a comminuted, depressed skull fracture
with a large intraparenchymal hematoma containing bone fragments. 相似文献
2.
Reed JL Brewah YA Delaney T Welliver T Burwell T Benjamin E Kuta E Kozhich A McKinney L Suzich J Kiener PA Avendano L Velozo L Humbles A Welliver RC Coyle AJ 《The Journal of infectious diseases》2008,198(12):1783-1793
Although respiratory syncytial virus (RSV) infection is the most important cause of bronchiolitis in infants, the pathogenesis of RSV disease is poorly described. We studied histopathologic changes in a panel of lung tissue specimens obtained from infants with fatal cases of primary RSV infection. In these tissues, airway occlusion with accumulations of infected, apoptotic cellular debris and serum protein was consistently observed. Similar observations were found after RSV infection in New Zealand black (NZB) mice, which have constitutive deficiencies in macrophage function, but not in BALB/c mice. A deficiency in the number of alveolar macrophages in NZB mice appears to be central to enhanced disease, because depletion of alveolar macrophages in BALB/c mice before RSV exposure resulted in airway occlusion. In mice with insufficient numbers of macrophages, RSV infection yielded an increased viral load and enhanced expression of type I interferon-associated genes at the height of disease. Together, our data suggest that innate, rather than adaptive, immune responses are critical determinants of the severity of RSV bronchiolitis. 相似文献
3.
Limperger Verena Kenet Gili Kiesau Bettina Köther Max Schmeiser Malin Langer Florian Juhl David Shneyder Maria Franke Andre Klostermeier Ulrich K. Mesters Rolf Rühle Frank Stoll Monika Steppat Dagmar Kowalski Dorothee Rocke Angela Kuta Piotr Bajorat Tido Torge Antje Neuner Bruno Junker Ralf Nowak-Göttl Ulrike 《Journal of thrombosis and thrombolysis》2021,51(2):494-501
Journal of Thrombosis and Thrombolysis - The role of the A>G polymorphism at position 19911 in the prothrombin gene (factor [F] 2 at rs3136516) as a risk factor for venous thromboembolism... 相似文献
4.
5.
Kolden GG Strauman TJ Ward A Kuta J Woods TE Schneider KL Heerey E Sanborn L Burt C Millbrandt L Kalin NH Stewart JA Mullen B 《Psycho-oncology》2002,11(5):447-456
Evidence is accumulating for physical activity as an effective, well-tolerated, highly rewarding complementary behavioral intervention for enhancing quality of life (QOL) as well as fitness among individuals with chronic and even terminal illnesses. However, relatively few studies have examined the feasibility and potential health benefits of supervised, structured exercise programs for sedentary women with primary breast cancer. Forty women over the age of 45 with primary breast cancer participated in a course of group exercise training (GET) delivered in a structured format three times per week for 16 weeks. GET emphasizes physical activities that promote aerobic fitness, strength, and flexibility. Assessments of fitness/vigor and QOL were conducted prior to, during, and upon completion of the program. Results demonstrated that GET was feasible, safe, and well-tolerated. Moreover, the participants experienced significant health benefits over the course of the intervention in multiple dimensions of fitness/vigor (aerobic capacity, strength, flexibility) as well as QOL (increased positive affect, decreased distress, enhanced well-being, and improved functioning). Discussion highlights the need for inclusion of physical activity programs in comprehensive, complementary treatment regimes for breast cancer patients. 相似文献
6.
A E Kuta C L Bashford C A Pasternak C W Reynolds P A Henkart 《Molecular immunology》1991,28(11):1263-1270
In order to understand the nature of cytolysin-membrane interactions, the characteristics of stable, non-lytic cytolysin-target cell intermediates formed at low ionic strength, neutral pH, and at physiological ionic strength, pH 6.0, were examined. Protease treatment of cytolysin-RBC intermediates formed at low ionic strength inhibited subsequent hemolysis when the intermediates were exposed to physiological ionic strength and pH. Similarly, when such intermediates were treated with anti-granule and anti-cytolysin antibodies a significant dose-dependent inhibition of hemolysis was observed. These results suggested that in this non-lytic state the cytolysin molecule was exposed on the RBC surface. If low ionic strength or pH 6.0 generated intermediates were washed in 0.5 M NaCl, hemolytic activity was greatly reduced and cytolysin activity could be recovered from the medium. In addition to RBC, both murine (Yac-1 and Lettre ascites) and human (K562) tumor targets formed cytolysin-target cell intermediates at low ionic strength and at low pH. Multilamellar vesicles composed of either phosphatidylcholine, sphingomyelin or phosphatidylserine inhibited the binding of cytolysin to RBC at both low ionic strength and pH 6.0 indicating a lack of polar head group specificity for cytolysin binding. 相似文献
7.
8.
Dr. J. Böswart I. Kuta Z. Lisý P. Kostiuk 《European journal of applied physiology》1980,43(3):193-199
Summary The effect of physical exercise on erythrocyte 2,3-diphosphoglycerate (2,3-DPG) content was studied in eight trained speed canoeists aged 15–25 years. One-stage 4-min load on a paddling ergometer corresponding to a 1 km race was observed. During the test, the following cardiorespiratory parameters were recorded:
. Blood lactate level and haematocrit were also determined. The average resting values of 2,3-DPG and haematocrit were statistically significant increased.After 6 month intense training there was a significant increase in 2,3-DPG, and the other parameters were also increased.Abbreviations 2,3-DPG
2,3-diphosphoglycerate
- Hc
haematocrite
-
pulmonary ventilation
-
oxygen uptake
-
oxygen uptake per one kg of body weight
- HR
heart rate
-
pulse oxygen
- R
respiratory quotient
- La
lactate
- ¯x
arithmetical mean
- SD
standard deviation
-
t
value of t-test for paired comparisons 相似文献
9.
Pope BD Chandra T Buckley Q Hoare M Ryba T Wiseman FK Kuta A Wilson MD Odom DT Gilbert DM 《Human molecular genetics》2012,21(19):4162-4170
In multicellular organisms, developmental changes to replication timing occur in 400-800 kb domains across half the genome. While examples of epigenetic control of replication timing have been described, a role for DNA sequence in mammalian replication-timing regulation has not been substantiated. To assess the role of DNA sequences in directing developmental changes to replication timing, we profiled replication timing in mice carrying a genetically rearranged Human Chromosome 21 (Hsa21). In two distinct mouse cell types, Hsa21 sequences maintained human-specific replication timing, except at points of Hsa21 rearrangement. Changes in replication timing at rearrangements extended up to 900 kb and consistently reconciled with the wild-type replication pattern at developmental boundaries of replication-timing domains. Our results are consistent with DNA sequence-driven regulation of Hsa21 replication timing during development and provide evidence that mammalian chromosomes consist of multiple independent units of replication-timing regulation. 相似文献
10.
Jim Secka Arpan Pal Francis A. Acquah Blaine H. M. Mooers Anand B. Karki Dania Mahjoub Mohamed K. Fakhr David R. Wallace Takuya Okada Naoki Toyooka Adama Kuta Naga Koduri Deacon Herndon Kenneth P. Roberts Zhiguo Wang Bethany Hileman Nisha Rajagopal Syed R. Hussaini 《RSC advances》2022,12(30):19431
This paper describes the synthesis of enamino carbonyl compounds by the copper(i)-catalyzed coupling of acceptor-substituted diazo compounds and tertiary thioamides. We plan to use this method to synthesize indolizidine (−)-237D analogs to find α6-selective antismoking agents. Therefore, we also performed in silico α6-nAchRs binding studies of selected products. Compounds with low root-mean-square deviation values showed more favorable binding free energies. We also report preliminary pharmacokinetic data on indolizidine (−)-237D and found it to have weak activity at CYP3A4. In addition, as enamino carbonyl compounds are also known for antimicrobial properties, we screened previously reported and new enamino carbonyl compounds for antibacterial, antimicrobial, and antifungal properties. Eleven compounds showed significant antimicrobial activities.This paper describes the synthesis of enamino carbonyl compounds by the copper(i)-catalyzed coupling of acceptor-substituted diazo compounds and tertiary thioamides. 相似文献