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排序方式: 共有182条查询结果,搜索用时 15 毫秒
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The Role of APO-1-Mediated Apoptosis in the Immune System 总被引:12,自引:0,他引:12
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Kapfhammer R. Höber Hasebroek Holthusen Halberstaedter H. Hirschfeld Sperling Vaternahm Seligmann Warsow Peiper K. Hirschfeld Jonas Gottschalk Lewy Grassheim Weigert Schmitz Finkenrath Zinn Deusch W. Zinn Koenigsfeld H. Kalk Melchior A. W. Fischer Dietlen Oppenheimer Starkenstein Edens Rosenow H. W. Knipping Flaskamp W. Israel Dietrich Jaffé Langer 《Journal of molecular medicine (Berlin, Germany)》1927,6(32):1528-1535
Ohne Zusammenfassung 相似文献
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H. W. Knipping Roth Schlomka Ludwig Seitz Gaupp Gruhle Flury Th. Vaternahm Gundel W. Artelt 《Journal of molecular medicine (Berlin, Germany)》1939,18(3):100-102
Ohne Zusammenfassung 相似文献
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Stephan Knipping H. J. Holzhausen A. Riederer T. Schrom 《European archives of oto-rhino-laryngology》2009,266(8):1249-1256
Nasal hyperreactivity is one of the most important underlying mechanisms in both allergic (AR) and idiopathic rhinitis (IR).
In order to study the pathomorphological changes in this entity, tissue samples from patients with AR, IR, and from patients
without chronic inflammation were taken during nasal surgery. Primary antibodies against Substance P (SP), calcitonin gene-related
peptide (CGRP), and endothelial nitric oxide synthases (NOS III) were applied and the immunocomplexes were visualized by immunocytochemistry.
The nasal mucosa of patients with AR and IR showed similarities on the ultrastructural level. Neurogenic inflammation was
indicated by a strong innervation pattern with sensory nerve fibers containing SP and CGRP. We could show that extensive edema
and cellular infiltration might be characteristic for AR. On other hand there was no evidence of eosinophilic or NO involvement
in IR. Finally, on the ultrastructural level, AR and IR showed many similarities. Based on these findings anti-inflammatory
therapy modalities could be recommended for both types of rhinitis.
This study was presented at the XXVII EAACI Congress, June 7–11, 2008, in Barcelona, Spain. 相似文献
8.
Primary ciliary dyskinesia syndrome (PCD) is a rare, autosomal receive disorder. Kartagener's syndrome is a subgroup of the PCD with situs inversus, bronchiectasis, and sinusitis. The symptoms results from an abnormal ultrastructural morphology of the cilia such as absence of dynein arms and other changes. As a consequence ciliary motility is disturbed. A 25-year-old man was examined because he suffered from recurrent severe pneumonia and Aspergillus infections of the lungs. On electron micrographs, ciliary abnormalities including deficiency of inner and outer dynein arms, dysmorphic outer dynein arms, and disorientation of the cilia were demonstrated. The diagnosis of PCD requires electron-microscopic investigations of the ciliated mucosa. Special attention should be given to ultrastructural changes of nasal or bronchial mucosa if a young patient suffers from recurrent severe respiratory infections. 相似文献
9.
Extracranial meningiomas are rare tumors of the lateral skull base. A 37-year-old woman presented with tinnitus und progressive hearing loss of her right ear. A painful mass lesion was also palpable in her mandibular angle. CT and MRI scans revealed an intracranial mass with extension to the lateral skull base. These findings suggested the occurrence of a paraganglioma or meningioma. In a two-stage surgical procedure tumor was extirpated without functional impairment to the patient. Histology of the excised lesion demonstrated an endotheliomatous meningioma. Since an extracranial meningioma can present as a mass lesion of the lateral skull base, CT and MRI scans are essential in preoperative surgical planning. 相似文献
10.
BACKGROUND: Infections of the orbit and of the periorbital region are not uncommon. Even today they constitute a serious problem, in spite of modern antibiotic treatment, with a potential risk of lethal complications. Orbital infections are most prevalent in children and adolescents. The acute orbit has many causes, but the most frequent is an occurrence secondary to acute rhinosinusitis. PATIENTS AND METHODS: Based on clinical cases, different causes and the present state of diagnosis are presented. The discussion deals with therapeutic strategies depending on the stage according to the current classification of orbital inflammation. CONCLUSIONS: Orbital and periorbital inflammations represent a demanding challenge for interdisciplinary cooperation between ophthalmologists, ENT specialists and radiologists. In some cases maxillofacial surgeons and neurosurgeons have to be included as well. Accurate diagnosis and treatment may lead to the resolution of the infection and avoid ocular sequel or endocranial complications as well as a fatal outcome. 相似文献