全文获取类型
收费全文 | 15690篇 |
免费 | 864篇 |
国内免费 | 77篇 |
专业分类
耳鼻咽喉 | 146篇 |
儿科学 | 251篇 |
妇产科学 | 228篇 |
基础医学 | 2145篇 |
口腔科学 | 608篇 |
临床医学 | 1100篇 |
内科学 | 3653篇 |
皮肤病学 | 366篇 |
神经病学 | 1099篇 |
特种医学 | 786篇 |
外科学 | 2703篇 |
综合类 | 70篇 |
预防医学 | 479篇 |
眼科学 | 267篇 |
药学 | 999篇 |
中国医学 | 12篇 |
肿瘤学 | 1719篇 |
出版年
2023年 | 83篇 |
2022年 | 156篇 |
2021年 | 294篇 |
2020年 | 141篇 |
2019年 | 195篇 |
2018年 | 306篇 |
2017年 | 229篇 |
2016年 | 276篇 |
2015年 | 287篇 |
2014年 | 324篇 |
2013年 | 427篇 |
2012年 | 746篇 |
2011年 | 785篇 |
2010年 | 439篇 |
2009年 | 397篇 |
2008年 | 733篇 |
2007年 | 727篇 |
2006年 | 801篇 |
2005年 | 836篇 |
2004年 | 786篇 |
2003年 | 745篇 |
2002年 | 838篇 |
2001年 | 458篇 |
2000年 | 494篇 |
1999年 | 518篇 |
1998年 | 254篇 |
1997年 | 196篇 |
1996年 | 177篇 |
1995年 | 122篇 |
1994年 | 135篇 |
1993年 | 141篇 |
1992年 | 339篇 |
1991年 | 331篇 |
1990年 | 285篇 |
1989年 | 284篇 |
1988年 | 300篇 |
1987年 | 257篇 |
1986年 | 238篇 |
1985年 | 220篇 |
1984年 | 165篇 |
1983年 | 115篇 |
1982年 | 62篇 |
1981年 | 65篇 |
1979年 | 129篇 |
1978年 | 72篇 |
1977年 | 62篇 |
1976年 | 61篇 |
1975年 | 62篇 |
1974年 | 59篇 |
1971年 | 56篇 |
排序方式: 共有10000条查询结果,搜索用时 12 毫秒
1.
Sentinel lymph node biopsy for 102 patients with primary cutaneous melanoma at a single Japanese institute
下载免费PDF全文
![点击此处可从《The Journal of dermatology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Masaki Otsuka Osamu Yamasaki Tatsuya Kaji Keiji Iwatsuki Kenji Asagoe 《The Journal of dermatology》2015,42(10):954-961
Sentinel lymph node biopsy (SLNB) is a widely accepted standard procedure for patients with clinically localized melanoma. Melanoma prevalence and Clark's subtype differ between Asians and Caucasians. Here, we evaluated our experience on SLNB for cutaneous melanoma in a Japanese population. SLNB was performed for patients with melanoma between July 2000 and June 2014. We retrospectively analyzed 102 patients regarding association of clinicopathological features with sentinel lymph node (SLN) status, melanoma‐specific survival (MSS) and disease‐free survival (DFS). A positive SLN was significantly associated with primary Breslow thickness. Compared with 43 patients with negative SLN, 59 patients with positive SLN had significantly shorter MSS (5‐year survival rate, 94.3% vs 63.2%; P = 0.0002) and DFS (5‐year survival rate, 92.7% vs 63.4%; P = 0.0004). According to our subgroup analyses, nine patients with positive non‐SLN had significantly shorter MSS compared with 32 patients with negative non‐SLN (5‐year survival rate, 32.4% vs 68.5%; P = 0.0273). The survival of 51 Japanese patients with acral lentiginous melanoma (ALM) was not inferior to the survival of patients with other Clark's subtype. Breslow thickness is an important factor for both MSS and DFS, and the status of SLN is the most predictive prognostic factor in Japanese patients with clinically localized melanomas, as in case of Caucasians. Features of ALM may be different between Asians and Caucasians. 相似文献
2.
3.
Hiroto Kinoshita Hitomi Nishioka Aya Ikeda Kyoko Ikoma Yoichi Sameshima Hidehisa Ohi Mizuki Tatsuno Junka Kouyama Chiaki Kawamoto Tomohiro Mitsui Yuko Tamura Yu Hashimoto Masashi Nishio Tsuyoshi Ogashiwa Yusuke Saigusa Shin Maeda Hideaki Kimura Reiko Kunisaki Kazuhiko Koike 《Journal of gastroenterology and hepatology》2019,34(11):1929-1939
4.
5.
A 1:1 adduct of methyl sorbate (MS) and 1,3‐di‐tert‐butylimidazol‐2‐ylidene (NHCtBu) initiates anionic polymerization of a nonconjugated polar alkene, allyl methacrylate (AMA) in toluene at ?20 °C. After the monomer is consumed quantitatively using a bulky aluminum Lewis acid, methylaluminum bis(2,6‐di‐tert‐butyl‐4‐methylphenoxide) (MAD), as an additive, successive ring‐closure occurs without highly dilute conditions to give a cyclic poly(AMA) containing α‐terminal MS unit, and an Mn of 8.8 × 103?58.5 × 103 with a narrow molecular dispersity index (Mw/Mn = 1.14–1.37). The lack of a need for dilution is due to the fact that an α‐terminal NHCtBu group is acting as the counter cation for the propagating center in the polymerization. From 1H NMR and matrix assisted laser desorption/ionization (MALDI‐TOF) mass spectra, combined with transmittance electron microscope (TEM) observation of a synthesized poly(AMA) with longer alkyl side chains prepared via a thiol‐ene click reaction, it is concluded that once the monomer is consumed, nucleophilic attack at the neighboring methine of the α‐terminal NHCtBu residue by the propagating anionic center causes ring‐closing to cyclic poly(AMA). 相似文献
6.
7.
Kengo Maeda Shinji Kume Yoshihiko Nishio Shiro Maeda Yasuhiro Nishida Mikio Suzuki Takahiro Nakaguchi Toru Kawabata Osamu Hashimoto Takashi Hisanaga Atsunori Kashiwagi Hitoshi Yasuda 《Clinical neurology》2006,46(4):266-269
We report a 53-year-old woman with severe Graves' ophthalmopathy accompanied by uncontrolled myasthenia gravis. She presented remarkable exophthalmos, chemosis, and restriction of eye movement. Despite plasma exchange, steroid pulse therapy, local injection of steroid, and irradiation, ocular symptoms did not ameliorate. Since optic neuropathy was seen, orbital decompression surgery was performed in the left eye. Bilateral chemosis was improved after the surgery. Five years after surgery, there was no ocular palsy in the operated left eye, but in the contralateral eye. For the good prognosis of the eye movement, orbital decompression might be recommended in the severe Graves' ophthalmopathy accompanied by the optic neuropathy and/or ophthalmoplegia with proptosis. 相似文献
8.
Keiji Iwai 《Seishin shinkeigaku zasshi》2006,108(5):470-474
9.
10.
Takako Miyamae Masaaki Mori Yasuji Inamo Youichi Kohno Shuji Takei Motoharu Maeda Takuji Murata Shuji Nakata Hiroshi Kawai Yukiko Hirano Yukiji Date Katsuhiko Kitamura Shumpei Yokota 《Ryūmachi》2003,43(3):538-543
OBJECTIVES: To reveal the frequency and the clinical characteristics of dystrophic calcification that occurs in children with juvenile dermatomyositis, multi-center analysis was constructed. METHOD: Fifty children with JDM were enrolled, and 14 of them (28.0%) were complicated with calcinosis. Clinical symptoms and laboratory tests at onset, initial therapy and disease course were compared in children with and without calcinosis. RESULTS: The mean age of the onset of calcinosis was 4.78 +/- 3.33 years, and it was younger than those of children without calcinosis (8.66 +/- 3.85 years) (P = 0.0017). No differences of clinical manifestation except Gower's sign were observed. The frequency of positive anti-nuclear antibody was 7.1% in children with calcinosis and 52.9% without calcinosis (P = 0.0112). The initial therapy of methylprednisolon pulses gave no effects on prognosis of calcium deposition. The calcinosis appeared in 1.56 +/- 1.91 year after the onset of the disease. The various types of calcium deposition including large tumorous clumps, subcutaneous plaques or nodules, sheet-type calcification were deserved. They appeared over knee joints (64.3%), elbow joint (64.3%), and hip processes (50.0%). Calcinosis affecting the subcutaneous tissues frequently resulted in painful superficial ulceration of the overlying skin (42.9%), local infection (50.0%), and limitation of joint movement (14.3%). Although aluminum phosphate was effective in 2 children among 7, no other effective treatment was recommended. In 5 cases, surgical removal of tumorous clumps was operated. Thus, juvenile dermatomyositis is frequently complicated with calcinosis. This type of calcinosis was found to be unlikely to resolve completely, and resulted in severe disability in children. 相似文献