全文获取类型
收费全文 | 7662篇 |
免费 | 410篇 |
国内免费 | 77篇 |
专业分类
耳鼻咽喉 | 78篇 |
儿科学 | 221篇 |
妇产科学 | 96篇 |
基础医学 | 916篇 |
口腔科学 | 228篇 |
临床医学 | 453篇 |
内科学 | 1775篇 |
皮肤病学 | 126篇 |
神经病学 | 588篇 |
特种医学 | 412篇 |
外科学 | 1696篇 |
综合类 | 23篇 |
预防医学 | 130篇 |
眼科学 | 64篇 |
药学 | 430篇 |
中国医学 | 9篇 |
肿瘤学 | 904篇 |
出版年
2023年 | 40篇 |
2022年 | 65篇 |
2021年 | 139篇 |
2020年 | 102篇 |
2019年 | 124篇 |
2018年 | 169篇 |
2017年 | 132篇 |
2016年 | 164篇 |
2015年 | 185篇 |
2014年 | 238篇 |
2013年 | 293篇 |
2012年 | 455篇 |
2011年 | 473篇 |
2010年 | 243篇 |
2009年 | 198篇 |
2008年 | 429篇 |
2007年 | 479篇 |
2006年 | 468篇 |
2005年 | 473篇 |
2004年 | 417篇 |
2003年 | 395篇 |
2002年 | 414篇 |
2001年 | 160篇 |
2000年 | 163篇 |
1999年 | 176篇 |
1998年 | 101篇 |
1997年 | 73篇 |
1996年 | 84篇 |
1995年 | 73篇 |
1994年 | 72篇 |
1993年 | 54篇 |
1992年 | 118篇 |
1991年 | 104篇 |
1990年 | 83篇 |
1989年 | 71篇 |
1988年 | 66篇 |
1987年 | 71篇 |
1986年 | 74篇 |
1985年 | 66篇 |
1984年 | 56篇 |
1983年 | 44篇 |
1982年 | 48篇 |
1981年 | 25篇 |
1980年 | 28篇 |
1979年 | 39篇 |
1978年 | 27篇 |
1977年 | 24篇 |
1975年 | 16篇 |
1974年 | 23篇 |
1973年 | 22篇 |
排序方式: 共有8149条查询结果,搜索用时 15 毫秒
1.
Heterozygous nonsense mutations near the C‐terminal region of IGF1R in two patients with small‐for‐gestational‐age‐related short stature
下载免费PDF全文
![点击此处可从《Clinical endocrinology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
2.
Akira Sugawara Kazuhisa Takeuchi Takashi Suzuki Keiichi Itoi Hironobu Sasano Sadayoshi Ito 《Hypertension research》2003,26(8):663-668
We describe a case of aldosterone-producing adrenocortical adenoma (APA) associated with a probable post-operative adrenal crisis possibly due to subtle autonomous cortisol secretion. The patient was a 46-year-old female who suffered from severe hypertension and hypokalemia. CT and MRI scans revealed a 2-cm diameter adrenal mass. The patient's plasma aldosterone level was increased, and her plasma renin activity was suppressed, both of which findings were consistent with APA. Cushingoid appearance was not observed. Morning and midnight serum cortisol and plasma adrenocorticotropic hormone (ACTH) levels were all within the normal range. Her serum cortisol level was suppressed to 1.9 microg/dl as measured by an overnight 1-mg dexamethasone suppression test, but was incompletely suppressed (2.7 microg/dl) by an overnight 8-mg dexamethasone suppression test. In addition, adrenocortical scintigraphy showed a strong uptake at the tumor region and a complete suppression of the contra-lateral adrenal uptake. After unilateral adrenalectomy, she had an episode of adrenal crisis, and a transient glucocorticoid replacement improved the symptoms. Histopathological studies demonstrated that the tumor was basically compatible with APA. The clear cells in the tumor were admixed with small numbers of compact cells that expressed 17alpha-hydroxylase, suggesting that the tumor was able to produce and secrete cortisol. In addition, the adjacent non-neoplastic adrenal cortex showed cortical atrophy, and dehydroepiandrosterone sulfotransferase immunoreactivity in the zonae fasciculata and reticularis was markedly diminished, suggesting that the hypothalamo-pituitary-adrenal (HPA) axis of the patient was suppressed due to neoplastic production and secretion of cortisol. Together, these findings suggested that autonomous secretion of cortisol from the tumor suppressed the HPA axis of the patient, thereby triggering the probable post-operative adrenal crisis. Post-operative adrenocortical insufficiency should be considered in clinical management of patients with relatively large APA, even when physical signs of autonomous cortisol overproduction are not apparent. 相似文献
3.
4.
S. Horita T. Shinoda H. Yoshimoto M. Masuo Y. Miura 《Clinical and experimental nephrology》2002,6(1):71-74
We report a case of infectious endocarditis in a 77-year-old woman who was undergoing maintenance hemodialysis therapy, and
who was also having a prosthetic aortic valve replacement. The disease resulted from a local skin infection at the needle
puncture site of the arteriovenous fistula. Ampicillin-resistant Staphylococcus aureus was the causal organism. Surgical treatment could not be performed because of associated intracranial hemorrhage due to septic
embolism. In spite of intensive treatment with several antibiotics, a ventricular septal abscess just beneath the prosthetic
aortic valve progressed to form a ventricular septal fistula. The resultant intracardiac left-to-right shunt led to refractory
congestive heart failure. The patient finally died of heart failure. The formation of a ventricular septal fistula is considered
to be a rare and extraordinary complication of infectious endocarditis in a hemodialysis patient with aortic valve replacement.
Received: July 25, 2001 / Accepted: November 3, 2001 相似文献
5.
Changes in central dopaminergic systems with the expression of Shh or GDNF in mice perinatally exposed to bisphenol-A. 总被引:1,自引:0,他引:1
Kazuya Miyagawa Minoru Narita Michiko Narita Keiichi Niikura Hisahiko Akama Yuri Tsurukawa Tsutomu Suzuki 《Nihon shinkei seishin yakurigaku zasshi》2007,27(2):69-75
In the previous study, we reported that exposure to bisphenol-A induced the potentiation of dopamine receptor functions in the mouse limbic area, resulting in supersensitivity to methamphetamine-induced pharmacological actions. The present study was undertaken to investigate whether prenatal exposure to bisphenol-A could produce morphological change in dopaminergic neuron and the pattern of expression of genes regulating the dopaminergic neuron development. Here we found that prenatal and neonatal exposures to bisphenol-A increased the tyrosine hydroxylase- and dopamine transporter-like immunoreactivities in the adult mouse limbic area. The present molecular biological study shows that chronic bisphenol-A treatment produced a significant decrease in the dopaminergic neuron development factors, sonic hedgehog and glial cell line-derived neurotrophic factor, which were also decreased by prenatal exposure to bisphenol-A. These results suggest that chronic exposure to bisphenol-A could disrupt the dopaminergic neurotransmission in the process of dopaminergic neuron development. 相似文献
6.
T Yoshimoto K Higashino T Hada S Tamura K Nakanishi M Mitsunobu K Uematsu T Matsuoka K Taketa 《Cancer》1987,60(11):2744-2750
This article documents a patient with lung carcinoma that produced three oncofetal antigens including alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA), and human chorionic gonadotropin (hCG). Serum AFP, CEA, and hCG-beta-subunit were extremely high--118,000 ng/ml, 133 ng/ml and 0.9 ng/ml, respectively. Immunohistochemical staining of these tumor markers revealed that these proteins were present in different cells. The pattern of lectin affinity electrophoresis of AFP resembled that of hepatocellular carcinoma. Also investigated was the reactivity of serum CEA to monoclonal antibodies against peptide or sugar moieties. Serum CEA values measured by antipeptide monoclonal antibodies were higher than those measured by antisugar monoclonal antibodies. The demonstration of AFP, CEA, and hCG in different tumor cells suggests that three genomes were not reactivated together in a cell, and the lung carcinoma probably consisted of at least three clones of cancer cells with different phenotypes. 相似文献
7.
Yoichiro Hosokawa D.D.S. D.D.Sc. Kazuyuki Minowa D.D.S. Satoru Abe M.D. Keiichi Ohmori D.D.S. D.D.Sc. Michio Yamasaki M.D. D.M.Sc. Masanobu Shindoh D.D.S. D.D.Sc. Tadashi Iizuka D.D.S. D.D.Sc. Mohiuddin Ahmed B.D.S. Akira Amemiya D.D.S. D.D.Sc. 《Oral Radiology》1991,7(1):1-6
A case of an odontogenic tumor which invaded the intracranial space from the mandible is reported. Judging from the radiographic
images it was similar to a malignant tumor. The patient died 17 years after the first visit. According to the final pathological
diagnosis, it was malignant odontogenic mixed tumor of low grade which did not belong to any of the WHO classification. 相似文献
8.
9.
Hiroyuki Yamamoto Fumio Itoh Akinori Senota Yasushi Adachi Mitsuru Yoshimoto Takao Endoh Yuji Hinoda Akira Yachi Kohzoh Imai 《Journal of clinical laboratory analysis》1995,9(5):297-301
The matrix metalloproteinase matrilysin (MMP-7) is a member of the matrix metallo-proteinase gene family, which is believed to play an important role in tumor invasion and metastasis. We have previously found that matrilysin mRNA is specifically expressed in colorectal cancers and adenomas and that its message is localized in the tumor cells themselves. We examined the effects of activated Ki-ras oncogene on the expression of matrilysin in colon cancer cells. We showed that both mRNA and the enzymatic activity of matrilysin were induced by the introduction of activated Ki-ras into SW1417 colon cancer cells. To understand the mechanisms regulating this induction, we analyzed alterations of AP-1 activity induced by activated Ki-ras, using the chloramphenicol acetyltransferase assay. AP-1 activity in SW1417 cells expressing activated Ki-ras was higher than that in control cells. The gel-shift assay also showed higher levels of AP-1 binding protein in SW1417 cells expressing activated Ki-ras than those in control cells. Our results suggest that activated Ki-ras may play a role in inducing expression of matrilysin through an AP-1-dependent pathway in colon cancer cells. 相似文献
10.
Kanta Kishi Michiko Muramatsu Denan Jin Keiichi Furubayashi Shinji Takai Hiroshi Tamai Mizuo Miyazaki 《Hypertension research》2007,30(1):77-83
Chymase is known to generate angiotensin II in the vascular wall. In this study we investigated a novel role for chymase other than angiotensin II production in vascular proliferation after balloon injury. Chymase promoted the migration of vascular smooth muscle cells in the matrix-coated invasion chambers and activated promatrix metalloproteinase-2 obtained from the culture medium of vascular smooth muscle cells. Two weeks after balloon injury, significant neointimal formation was found in dog carotid arteries. After injury, active matrix metalloproteinase-2 was increased in parallel with the augmentation of chymase activity that was seen in the proliferating region of the vascular wall. The oral administration of NK3201 (1 mg/kg per day), a chymase inhibitor, prevented neointimal formation and significantly suppressed both active matrix metalloproteinase-2 and chymase activities 2 weeks after injury. These results suggest that chymase inhibitors can prevent the development of intimal hyperplasia via the inhibition of matrix metalloproteinase-2 activation in balloon-injured arteries. 相似文献