排序方式: 共有23条查询结果,搜索用时 11 毫秒
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Ghyslaine Bruna Djeunang Dongho Karthigayan Gunalan Mariangela LEpiscopia Giacomo Maria Paganotti Michela Menegon Rose Efeutmecheh Sangong Georges Bouting Mayaka Joseph Fondop Carlo Severini Martin Sanou Sobze Louis H. Miller Gianluca Russo 《The American journal of tropical medicine and hygiene》2021,104(3):987
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Timm Harder Sebastian Maurer-Stroh Anne Pohlmann Elke Starick Detlef H?reth-B?ntgen Karin Albrecht Gunter Pannwitz Jens Teifke Vithiagaran Gunalan Raphael T.C. Lee Carola Sauter-Louis Timo Homeier Christoph Staubach Carola Wolf Günter Strebelow Dirk H?per Christian Grund Franz J. Conraths Thomas C. Mettenleiter Martin Beer 《Emerging infectious diseases》2015,21(5):860-863
Highly pathogenic avian influenza (H5N8) virus, like the recently described H5N8 strain from Korea, was detected in November 2014 in farmed turkeys and in a healthy common teal (Anas crecca) in northeastern Germany. Infected wild birds possibly introduced this virus. 相似文献
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I. H. Mendenhall S. Borthwick E. S. Neves D. Low M. Linster B. Liang M. Skiles J. Jayakumar H. Han V. Gunalan B. P. Y.‐H. Lee K. Okahara L.‐F. Wang S. Maurer‐Stroh Y. C. F. Su G. J. D. Smith 《Transboundary and Emerging Diseases》2017,64(6):1790-1800
Coronaviruses are a diverse group of viruses that infect mammals and birds. Bats are reservoirs for several different coronaviruses in the Alphacoronavirus and Betacoronavirus genera. They also appear to be the natural reservoir for the ancestral viruses that generated the severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome coronavirus outbreaks. Here, we detected coronavirus sequences in next‐generation sequence data created from Eonycteris spelaea faeces and urine. We also screened by PCR urine samples, faecal samples and rectal swabs collected from six species of bats in Singapore between 2011 and 2014, all of which were negative. The phylogenetic analysis indicates this novel strain is most closely related to lineage D Betacoronaviruses detected in a diverse range of bat species. This is the second time that coronaviruses have been detected in cave nectar bats, but the first coronavirus sequence data generated from this species. Bat species from which this group of coronaviruses has been detected are widely distributed across SE Asia, South Asia and Southern China. They overlap geographically, often share roosting sites and have been witnessed to forage on the same plant. The addition of sequence data from this group of viruses will allow us to better understand coronavirus evolution and host specificity. 相似文献
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The nonstructural protein 8 (nsp8) of the SARS coronavirus interacts with its ORF6 accessory protein 总被引:2,自引:0,他引:2
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Rakesh Khilwani Peter J. Gilgunn Takashi D. Y. Kozai Emrullah Korkmaz Pallavi K. Gunalan X. Tracy Cui Gary K. Fedder 《Biomedical microdevices》2016,18(6):97
Stable chronic functionality of intracortical probes is of utmost importance toward realizing clinical application of brain-machine interfaces. Sustained immune response from the brain tissue to the neural probes is one of the major challenges that hinder stable chronic functionality. There is a growing body of evidence in the literature that highly compliant neural probes with sub-cellular dimensions may significantly reduce the foreign-body response, thereby enhancing long term stability of intracortical recordings. Since the prevailing commercial probes are considerably larger than neurons and of high stiffness, new approaches are needed for developing miniature probes with high compliance. In this paper, we present design, fabrication, and in vitro evaluation of ultra-miniature (2.7 μm x 10 μm cross section), ultra-compliant (1.4?×?10-2 μN/μm in the axial direction, and 2.6?×?10-5 μN/μm and 1.8?×?10-6 μN/μm in the lateral directions) neural probes and associated probe-encasing biodissolvable delivery needles toward addressing the aforementioned challenges. The high compliance of the probes is obtained by micron-scale cross-section and meandered shape of the parylene-C insulated platinum wiring. Finite-element analysis is performed to compare the strains within the tissue during micromotion when using the ultra-compliant meandered probes with that when using stiff silicon probes. The standard batch microfabrication techniques are used for creating the probes. A dissolvable delivery needle that encases the probe facilitates failure-free insertion and precise placement of the ultra-compliant probes. Upon completion of implantation, the needle gradually dissolves, leaving behind the ultra-compliant neural probe. A spin-casting based micromolding approach is used for the fabrication of the needle. To demonstrate the versatility of the process, needles from different biodissolvable materials, as well as two-dimensional needle arrays with different geometries and dimensions, are fabricated. Further, needles incorporating anti-inflammatory drugs are created to show the co-delivery potential of the needles. An automated insertion device is developed for repeatable and precise implantation of needle-encased probes into brain tissue. Insertion of the needles without mechanical failure, and their subsequent dissolution are demonstrated. It is concluded that ultra-miniature, ultra-compliant probes and associated biodissolvable delivery needles can be successfully fabricated, and the use of the ultra-compliant meandered probes results in drastic reduction in strains imposed in the tissue as compared to stiff probes, thereby showing promise toward chronic applications. 相似文献
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Grüber A Gunalan K Ramalingam JK Manimekalai MS Grüber G Preiser PR 《Infection and immunity》2011,79(7):2880-2888
Invasion of the host cell by the malaria parasite is a key step for parasite survival and the only stage of its life cycle where the parasite is extracellular, and it is therefore a target for an antimalaria intervention strategy. Multiple members of the reticulocyte binding protein homologues (RH) family are found in all plasmodia and have been shown to bind to host red blood cells directly. In the study described here, we delineated the erythrocyte binding domain (EBD) of one member of the RH family, termed Py235, from Plasmodium yoelii. Moreover, we have obtained the low-resolution structure of the EBD using small-angle X-ray scattering. Comparison of the EDB structure to other characterized Plasmodium receptor binding domains suggests that there may be an overall structural conservation. These findings may help in developing new approaches to target receptor ligand interactions mediated by parasite proteins. 相似文献
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Two cases of dislocation of total knee arthroplasty presented to us within the same week. The first patient is a 71-year-old woman who underwent bilateral primary total knee arthroplasty. The left knee dislocated three weeks after the surgery. Due to failure of conservative measures, she underwent revision total knee arthroplasty. The other patient is a 72-year-old woman presenting ten years after primary total knee arthroplasty, with a traumatic dislocation of the knee joint. She was treated as an outpatient with closed manipulative reduction. 相似文献
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Oon Tek Ng Koh Cheng Thoon Hui Ying Chua Natalie Woon Hui Tan Chia Yin Chong Nancy Wen Sim Tee Raymond Tzer Pin Lin Lin Cui Indumathi Venkatachalam Paul Anantharajah Tambyah Jonathan Chew Raymond Kok Choon Fong Helen May Lin Oh Prabha Unny Krishnan Vernon Jian Ming Lee Boon Huan Tan Sock Hoon Ng Pei Jun Ting Sebastian Maurer-Stroh Vithiagaran Gunalan Wei Xin Khong 《Emerging infectious diseases》2015,21(7):1192-1196
During November 2012–July 2013, a marked increase of adenovirus type 7 (Ad7) infections associated with severe disease was documented among pediatric patients in Singapore. Phylogenetic analysis revealed close genetic links with severe Ad7 outbreaks in China, Taiwan, and other parts of Asia. 相似文献