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Decreased L-selectin expression in CD34-positive cells from patients with chronic myelocytic leukaemia 总被引:1,自引:0,他引:1
KUNIKO KAWAISHI AKIRO KIMURA OSAMU KATOH AYAKO SASAKI NOBUO OGUMA AKIHIRO IHARA YUKIO SATOW 《British journal of haematology》1996,93(2):367-374
Abnormal adhesive interaction between bone marrow stroma and progenitors, one of the causes of unregulated proliferation in chronic myelocytic leukaemia (CML), may be caused by some alterations in adhesion molecules on CML progenitors. We investigated the expression of adhesion molecules (CD44, VLA-5, VLA-4, LFA-1, ICAM-1, L-selectin and c-kit) on bone marrow CD34++ cells from 16 CML patients by three-colour flow cytometry. The mean percentage of cells expressing L-selectin in the CD34++ CD38+ ∼ ++ fraction from untreated CML patients was significantly lower, and that in the CD34++ CD38− fraction tended to be lower than that from normal controls. Among 11 CML patients treated with interferon-α (IFN-α), the mean percentage of the cells expressing L-selectin in the CD34++ CD38− fraction from three patients with a low percentage of Ph1 (+) cells in bone marrow was significantly higher than that from five patients with a high percentage of Ph1 (+) cells. In addition, L-selectin expression rate was inversely correlated to the percentage of Ph1 (+) cells. There was no significant difference between the untreated patients and normal controls with regard to the expression rates of the other adhesion molecules in each CD34++ fraction except LFA-1. These data suggest that decreased L-selectin expression in CML CD34++ cells reflects one of the features of malignant CML progenitors. 相似文献
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TATSUYA AIKAWA IZUMI KIMURA MAKI KOJIMA CHISATO UENO KUNIKO MIYAMOTO TOSHIRO TANGO NAOMI TANAKA 《Journal of gastroenterology and hepatology》1996,11(4):341-346
The loss of haemolytic activity in sera during storage at low temperature (the cold activation of complement) was observed in 136 of 184 (74%) patients with chronic liver disease associated with hepatitis C virus (HCV) infection. This was more frequent than observed in the three of 40 (8%) patients with chronic hepatitis B (P < 0.001) or none in 43 normal controls (P < 0.001). Of 103 patients with chronic hepatitis C who had completed a full course of recombinant interferon-α2a therapy (total dose: 516×106U), 40 responded completely and 21 responded partially, as judged by the normalization or decrease of alanine aminotransferase levels 6 months after the completion of therapy; 42 patients did not respond at all. The cold activation of complement persisted in five (13%) complete responders, less often than in 33 (79%) non-responders (P < 0.001). At the completion of interferon therapy, the cold activation of complement persisted in 12 of 54 patients despite the normalization of alanine aminotransferase. Spontaneous exacerbation of hepatitis occurred in seven of 12 (58%) patients with cold activation, which was more frequent than in the four of 42 patients (10%) without it (P < 0.01). The cold activation of complement disappeared along with the loss of HCV-RNA in five of six responders during the 6 month period after the completion of interferon therapy, while both cold activation and HCV-RNA persisted in all eight non-responders. These results indicate that the cold activation of complement may be useful as a marker of HCV viraemia for monitoring the response to interferon in patients with HCV infection. 相似文献
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