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排序方式: 共有537条查询结果,搜索用时 46 毫秒
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TYPHUS DISEASE GROUP 总被引:1,自引:0,他引:1
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PETER P. KARPAWICH KENNETH B. STOKES JOHN R. HELLAND CHERYL D. JUSTICE JACQELINE O. ROSKAMP 《Pacing and clinical electrophysiology : PACE》1988,11(8):1139-1148
A prospective comparison of pacing and sensing capabilities between the conventional Medtronic Model 4951 platinum-iridium epicardial pacing electrode and a new modified "platinized" version of the same electrode was performed in immature canines to determine if the new electrode design improves pacing in the immature myocardium. The conventional electrode was modified by electroplating platinum black particles onto the surface to increase the effective or true microscopic surface area, yet essentially maintain the same overall geometric electrode size. Both epicardial electrodes were inserted into the right ventricular myocardium with the lead pad sutured to the epicardium, and externalized to the scruff in five puppies (age 3 months). An additional left ventricular lead was implanted to permit chronic pacing following epicardially-induced atrioventricular block. Acute and chronic sensing and pacing capabilities of each externalized electrode were performed at implant and weekly up to 4 months. Histologic examination of each electrode implant site was performed at the end of the study period. At implant, both electrodes exhibited comparable values for sensed R waves, lead impedances, and pacing thresholds. During the study, the platinized electrode exhibited lower pacing thresholds. Analysis of all postimplant data demonstrated this threshold difference to be significantly lower (P less than .01) for the platinized version. Lead impedance and sensing capabilities remained comparable between the two designs. Histologic study demonstrated less fibrotic infiltration at the platinized electrode site. This preliminary evaluation indicates that for the duration of the postimplant study period, the platinized epicardial electrode design was associated with significantly lower thresholds and less fibrosis as a function of time compared to the conventional smooth electrode surface design. The new platinized electrode limits exit block in the developing immature myocardium and permits safe pacing at lower pulse widths and voltages to increase battery life. 相似文献
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Autoimmunity to Spermatozoa and the Testis 总被引:2,自引:0,他引:2
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SIGALL K. BELL PETER B. SMULOWITZ ALAN C. WOODWARD MICHELLE M. MELLO ANJALI MITTER DUVA RICHARD C. BOOTHMAN KENNETH SANDS 《The Milbank quarterly》2012,90(4):682-705
Context: The Disclosure, Apology, and Offer (DA&O) model, a response to patient injuries caused by medical care, is an innovative approach receiving national attention for its early success as an alternative to the existing inherently adversarial, inefficient, and inequitable medical liability system. Examples of DA&O programs, however, are few. Methods: Through key informant interviews, we investigated the potential for more widespread implementation of this model by provider organizations and liability insurers, defining barriers to implementation and strategies for overcoming them. Our study focused on Massachusetts, but we also explored themes that are broadly generalizable to other states. Findings: We found strong support for the DA&O model among key stakeholders, who cited its benefits for both the liability system and patient safety. The respondents did not perceive any insurmountable barriers to broad implementation, and they identified strategies that could be pursued relatively quickly. Such solutions would permit a range of organizations to implement the model without legislative hurdles. Conclusions: Although more data are needed about the outcomes of DA&O programs, the model holds considerable promise for transforming the current approach to medical liability and patient safety. 相似文献
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Arterial blood oxygen tensions (Pao2 ) were compared with simultaneously obtained transcutaneous oxygen measurements (Tc o2 ) in 15 children during an acute asthma attack and in 18 children with an illness other than asthma. A close correlation between Tc o2 and Pao2 was obtained in the non-asthmatic group but not in the asthmatics. It is suggested that impaired cutaneous blood flow may explain this poor correlation. 相似文献
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KENNETH A. STOUTENBOROUGH JAMES M. SUTHERLAND HOWARD A. MEINEKE IRWIN J. LIGHT 《Acta paediatrica (Oslo, Norway : 1992)》1969,58(2):121-124
Erythropoietin levels (ESF) were measured in premature infants with and without the respiratory distress syndrome in an effort to define the role of intrauterine hypoxia in the genesis of the disease. No difference in levels could be detected between infants with and without the: respiratory distress syndrome. This suggests that either intrauterine hypoxia plays no role in the genesis of the respiratory distress syndrome or that the hypoxia is (1) of short duration, (2) of relatively long duration, or (3) remote with respect to the time of birth. The higher levels found in full-term infants suggested that hypoxia before birth is a more common feature of the term delivery than the premature delivery. 相似文献
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