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排序方式: 共有145条查询结果,搜索用时 375 毫秒
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YOSHIKAZU YONEI YOSUKE YOSHIZAKI NOBUHIRO TSUKADA YASUTAKA INAGAKI KEI MIYAMOTO OSAMU SUZUKI YASUYOSHI KIRYU TOSHIFUMI HIBI MASAYA ODA HIROMASA ISHII 《Journal of gastroenterology and hepatology》1996,11(7):681-685
An ultrastructural study of the colonic mucosa was performed in four patients with antibiotic-associated haemorrhagic colitis and new findings are reported. Colonoscopy was performed and biopsy specimens were obtained within 24 h of the onset of bloody diarrhoea. Colonoscopy demonstrated diffuse oedematous and haemorrhagic mucosa with erosions and white coat. Light microscopy revealed mucosal haemorrhage and inflammatory cell infiltration. Ultrastructurally, platelet aggregation was frequently present in the lumina of colonic mucosal capillaries, causing engorgement of red blood cells in adjacent microvessels. Mild to severe damage was observed in capillary endothelial cells, including discontinuity of basement membranes, gaps between endothelial cells and the destruction of capillaries. There was no evidence of microvascular spasm. In conclusion, our findings suggest that antibiotics directly or indirectly cause microcirculatory disturbances, which result in tissue damage and haemorrhage, in the colonic mucosa. 相似文献
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EIJI TAKEDA HIRONORI YAMAMOTO YUTAKA TAKETANI KEN-ICHI MIYAMOTO 《Pediatrics international》1997,39(4):508-513
Two distinct hereditary defects, vitamin D-dependent rickets type I (VDDR I) and type II (VDDR II), have been recognized in vitamin D metabolism. VDDR I is suggested to be a deficiency of the renal 25-hydroxyvitamin D (25(OH)D)-1α-hydroxylase. Muscle weakness and rickets are the prominent clinical findings. A normal physiologic dose of 1α-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 is sufficient to maintain remission of rickets in this disorder. VDDR II consists of a spectrum of intracellular vitamin D receptor (VDR) defects and is characterized by the early onset of severe rickets and associated alopecia. This can be attributed to mutations in the VDR gene. Massive doses of vitamin D analogs and calcium supplementation is usually required for the treatment; however, the response to therapy is sometimes variable. 相似文献
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HISAKI MAKIMOTO M.D. Ph.D. IKUTARO NAKAJIMA M.D. KOJI MIYAMOTO M.D. YUKO YAMADA M.D. HIDEO OKAMURA M.D. TAKASHI NODA M.D. Ph.D. TAKESHI AIBA M.D. Ph.D. SHIRO KAMAKURA M.D. Ph.D. KENGO KUSANO M.D. Ph.D. WATARU SHIMIZU M.D. Ph.D. KAZUHIRO SATOMI M.D. Ph.D. 《Pacing and clinical electrophysiology : PACE》2015,38(5):630-640
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MASANORI NOGUCHI DAISUKE DEGUCHI JUNICHIRO TORIWAKI KENSAKU MORI YOSHITO MEKADA KEI MATSUOKA 《International journal of urology》2006,13(10):1296-1303
AIM: We evaluated a prostate biopsy strategy for cancer detection using a computer simulation system with virtual needle biopsy for three-dimensional (3D) prostate models. METHODS: Two 3D prostate models with a volume of 25 cc or 50 cc were constructed from computed tomographic images of radical prostatectomy specimens. The peripheral zone (PZ) and transition zone (TZ) were arranged in the prostate models according to the anatomical information. Four thousand patterns of cancer lesions were automatically inserted into each prostate model with a proportion of 75% in PZ and 25% in TZ. Average hit rates (AHR) in prostate models were evaluated both with an increased number of biopsy cores and various angles of virtual needle biopsy. The influence of adding secondary tumors for hit rates was also evaluated. RESULTS: For both sizes, the laterally angled biopsy in 4-8 core biopsy schemes showed higher AHR than the vertical plane biopsy, while the vertical plane biopsy in 10-18 core biopsy schemes showed higher AHR than the laterally angled biopsy. A higher number of biopsy cores increased the AHR of secondary tumors. CONCLUSIONS: Our results suggest that it is important in prostate cancer detection to change the needle placement according to the number of biopsy cores and the size of the prostate. 相似文献
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H. MIYAMOTO T. NAGATANI S. MOHRI H. NAKAJIMA 《Clinical and experimental dermatology》1988,13(6):411-415
Intravascular papillary endothelial hyperplasia (IPEH) was first described by Masson.1 It is characterized by the development of endothelial-lined papillary projections in a vascular lumen. In Japan the disease was first reported by Tanimura et al.2 in 1976, and since then over 30 cases have been described. In this reort we describe a case of IPEH together with the review of these Japanese cases. 相似文献
8.
TOSHIAKI NAKASHIMA NINKO MATSUMOTO YOSHIKI NAKAJIMA HIROKI ISHIKAWA HIRONORI MITSUYOSHI KOJI INABA MOTONARI SAKAI YOSHIKUNI SAKAMOTO MASAYUKI MATSUMOTO TOSHIHIDE SHIMA KEI KASHIMA TADAHITO KITAYOSHI NORIO SHIMAMOTO 《Journal of gastroenterology and hepatology》1998,13(1):81-87
The aim of the present study was to clarify whether bile acids influence chemiluminescence (CL) in the liver in vivo. Hepatic CL was determined on the surface of the liver of anaesthetized rats by using a photon counter. In normal rats, hepatic CL was significantly decreased 30 min after enteral administration of chenodeoxycholic acid (CDCA) or deoxycholic acid (DCA), but returned to its initial level 3 h later, after part of the CDCA administered was metabolized. Ursodeoxycholic acid (UDCA) and cholic acid had no effect on CL. In contrast, hepatic CL was markedly increased 30 min after CDCA or DCA administration in rats given either buthionine sulphoximine (BSO), an inhibitor of γ-glutamylcysteine synthetase, or diethyldithiocarbamate (DDC), an inhibitor of both superoxide dismutase and glutathione peroxidase. Chenodeoxycholic acid further increased the CL of BSO- or DDC-treated rats during inhalation of oxygen via a tracheal cannula. Coadministration of UDCA eliminated the effects of CDCA on the hepatic CL of normal and BSO- or DDC-treated rats with or without oxygen inhalation. We conclude that cytotoxic bile acids, such as CDCA, increase CL in the antioxidants-depleted or oxidative-stressed liver in vivc, but that UDCA prevents CDCA from developing CL. 相似文献
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Department of Surgery, Peiping Union Medical College, Pcleing, China
Primary carcirioma of the scalp seems to be a rare conditiont
as we failed to find any collective study of such cases in the English
literature. According to Hu and Chin (1), in the western countries,
basal cell carcinoma is much more common than squamous cell
carcinoma, but in China it is less frequent. Furtbermore, this affec-
tion presents peculiar features in its course and treatment which are
quite different from cancers of other internal or external organs of
the body. For these reasons, we feel that an analysis of the 35 cases
seen in the Peiping Union Medical College Hospital, in a period of
twenty years, may be reported. In each instance, except three, the
diagnosis was established by histopathological examination of the
tumor tissue; these cases were admitted to the Surgical and Tumor
Services. The three exceptions were patients who entered the hospital
for conditions other than the tumor itself, and the diagnosis was
based upon general physical examination. 相似文献