全文获取类型
收费全文 | 5149篇 |
免费 | 372篇 |
国内免费 | 22篇 |
专业分类
耳鼻咽喉 | 30篇 |
儿科学 | 56篇 |
妇产科学 | 50篇 |
基础医学 | 771篇 |
口腔科学 | 40篇 |
临床医学 | 589篇 |
内科学 | 1131篇 |
皮肤病学 | 84篇 |
神经病学 | 772篇 |
特种医学 | 311篇 |
外科学 | 744篇 |
综合类 | 14篇 |
预防医学 | 221篇 |
眼科学 | 40篇 |
药学 | 295篇 |
中国医学 | 6篇 |
肿瘤学 | 389篇 |
出版年
2023年 | 61篇 |
2022年 | 127篇 |
2021年 | 279篇 |
2020年 | 150篇 |
2019年 | 239篇 |
2018年 | 251篇 |
2017年 | 175篇 |
2016年 | 176篇 |
2015年 | 212篇 |
2014年 | 249篇 |
2013年 | 316篇 |
2012年 | 494篇 |
2011年 | 473篇 |
2010年 | 252篇 |
2009年 | 219篇 |
2008年 | 274篇 |
2007年 | 251篇 |
2006年 | 240篇 |
2005年 | 204篇 |
2004年 | 167篇 |
2003年 | 117篇 |
2002年 | 92篇 |
2001年 | 35篇 |
2000年 | 33篇 |
1999年 | 28篇 |
1998年 | 21篇 |
1997年 | 12篇 |
1996年 | 15篇 |
1995年 | 18篇 |
1994年 | 10篇 |
1993年 | 9篇 |
1992年 | 28篇 |
1991年 | 23篇 |
1990年 | 29篇 |
1989年 | 31篇 |
1988年 | 26篇 |
1987年 | 22篇 |
1986年 | 15篇 |
1985年 | 15篇 |
1984年 | 12篇 |
1983年 | 14篇 |
1982年 | 7篇 |
1981年 | 10篇 |
1980年 | 9篇 |
1979年 | 13篇 |
1977年 | 10篇 |
1975年 | 9篇 |
1974年 | 14篇 |
1973年 | 9篇 |
1972年 | 8篇 |
排序方式: 共有5543条查询结果,搜索用时 15 毫秒
1.
2.
3.
The aim of this pilot study was to examine the role of the striatum and cerebellum in the adaptation to a novel movement within a sequence of practiced movements using a motor learning paradigm. The performance of patients in the early or advanced stages of Parkinson's disease (PD) and of patients with damage to the cerebellum (CE) was compared, respectively to a group of aged and young matched controls on an adapted version of the Mirror-Tracing Test. In this task, subjects were required to trace a series of complex figures in two conditions: (1) a Practiced condition, in which the figures were composed of the juxtaposition of three simple designs that were extensively practiced before; and (2) a Mixed condition in which triads were created by replacing the last simple figure of the triads in the Practiced condition by a new simple figure that had never been traced individually before. Results showed that all clinical groups were slower than controls at tracing the Practiced triads. Most interestingly, however, only patients in the advanced stages of PD showed increased completion time to trace the triads in the Mixed condition. This suggests that a bilateral striatal dysfunction affects the ability to adapt to a novel motion within a sequence of practiced movements. Although exploratory, these results support a functional dissociation between the striatum and cerebellum in acquiring visuomotor skilled behaviors. 相似文献
4.
Julien Fey André Dietrich Anne Cosset T. Desprez L. Maréchal-Drouard 《Current genetics》1997,32(5):358-360
Two identical “chloroplast-like” tRNAAsn genes, trnN1 and trnN2, have been identified in the potato (Solanum tuberosum) mitochondrial genome. The flanking sequences of trnN1 are unrelated to the corresponding authentic potato chloroplast regions, whilst those of trnN2 are very similar to the chloroplast sequences. The trnN1 copy is present in the mitochondrial genome of various plants whereas the second copy, trnN2, is absent from all the other plant genomes studied so far. Interestingly, both trnN copies are expressed in potato mitochondria. Sequences flanking the chloroplast-like tRNAHis gene (trnH), present as a single copy in the potato mitochondrial DNA, are unrelated to the corresponding chloroplast sequences, whereas
chloroplast-derived sequences have been maintained in the vicinity of the maize chloroplast-like mitochondrial trnH gene. However, both the potato and the maize trnH are expressed in mitochondria.
Received: 10 April / 1 August 1997 相似文献
5.
Emmanuel Ellie Anne Vital Andreas Steck Jean-Michel Boiron Claude Vital Jean Julien 《Journal of neurology》1996,243(1):34-43
We studied 33 patients presenting with a peripheral neuropathy associated with non-malignant anti-myelin-associated glycoprotein (MAG) IgM monoclonal gammopathy (MG) in an attempt to delineate their clinical, immunological, electrophysiological and pathological characteristics; we also reviewed our experience concerning long-term follow-up and therapy. Peripheral neuropathy associated with non-malignant anti-MAG IgM MG was observed mostly in males (sex ratio 7.2), and mean age at onset was 67 years (range 46–81). A predominantly sensory pattern was noted in more than 80% of cases, although some patients were affected by a predominantly motor peripheral neuropathy. Although disease progression was slow in most cases, 45% of patients suffered severe disability, and in 2 cases, the patient's death appeared to stem directly from the neuropathy. The electrophysiological findings were indicative of a demyelinating process in 90% of cases, and electron microscopic examination of nerve biopsy specimens demonstrated widening of the myelin lamellae in more than 95% of cases. Most of our patients showed a disappointing response to steroids and chemotherapy or plasma exchanges. Intravenous immune globulin, evaluated in 17 patients, had a transient, mostly subjective effect in 35% and led to a clear-cut improvement in 24% of cases. We did not observe any correlation between the severity of the clinical picture and the anti-sulphoglucuronyl paragloboside antibody titre; in individual cases, clinical improvement occurred without lowering of IgM levels. Although the severity and the rate of progression may greatly vary from patient to patient, the combination of clinical, electrophysiological and pathological features delineates a characteristic pattern in peripheral neuropathy associated with non-malignant anti-MAG IgM MG. 相似文献
6.
Georgios Amoiridis Ludwig Gutmann Dennis E. Wilkins Raja Sawaya Alain Lagueny Roger Marthan Philippe Schuermans Philippe Le Collen Xavier Ferrer Jean Julien Reha Kuruoglu Shin J. Oh Brian Thompson A. Aggarwal L. Gutmann A. Gutierrez Okifumi Nakazato Russel Johnsen Philip Morling B. A. Kakulas 《Muscle & nerve》1994,17(2):245-253
7.
X Ferrer C Vital M Coquet B Deleplanque E Ellie A Lagueny J Julien 《Revue neurologique》1992,148(10):622-630
In a family 6 members in 3 generations were affected by centronuclear myopathy (CNM) of autosomal dominant inheritance. The apparent onset was in the early forties and the disease progressed slowly. Limb weakness was predominant. Strabismus was present in 5 cases and calves hypertrophy in 3. Serum creatinine kinase was always within the normal range. In one case myotonic bursts were found at electromyography. In 2 cases brain stem auditory evoked potential studies demonstrated abnormal prolongation of interpeak latencies I-III and favoured subclinical nervous system involvement. Muscular biopsies showed typical features of centronuclear myopathy with 50 to 80% central nuclei. In two cases immunocytochemical labelling of dystrophin showed staining in the sarcoplasm in favour of an arrest in the morphogenesis of developing myofiber. Others families with autosomal dominant CNM in the literature and also some sporadic adult cases had similar clinical features. 相似文献
8.
Daniel Van Gansbeke Thierry M. Metens Celso Matos Nicole Nicaise France Gay Hubert Raeymaekers Julien Struyven 《Journal of magnetic resonance imaging : JMRI》1997,7(3):482-489
This study was devoted to tumor differentiation in liver MR T1-weighted imaging with superparamagnetic iron oxide (SPIO). Twenty-one patients with 40 liver lesions were studied at 1.5 T. Before and at least 45 minutes after SPIO administration, turbo-field-echo (TFE) T1-weighted, TFE T1 × T2*-weighted (MXT), and fat-suppressed turbo-spin-echo T2-weighted images were acquired. A quantitative analysis was performed blindly. On TFE T1-weighted images, the signal enhancement was ?33% ± 12 for the liver, ?24% ± 2 for adenomas and focal nodular hyperplasia, +60% ± 33 for the hemangiomas; metastases and cyst enhancement were not significant. After SPIO on TFE T1-weighted images, the hemangioma-to-liver signal ratio (149% ± 18) was definitely higher than the mean metastasis-to-liver signal ratio (90% ± 16). This T1-related differentiation ability lacked dramatically on TFE MXT images and, in one case, was reduced on post-SPIO TFE T1-weighted images by a long imaging delay after SPIO administration (2 hours). 相似文献
9.