全文获取类型
收费全文 | 6260篇 |
免费 | 315篇 |
国内免费 | 27篇 |
专业分类
耳鼻咽喉 | 45篇 |
儿科学 | 115篇 |
妇产科学 | 77篇 |
基础医学 | 692篇 |
口腔科学 | 115篇 |
临床医学 | 706篇 |
内科学 | 1797篇 |
皮肤病学 | 91篇 |
神经病学 | 732篇 |
特种医学 | 106篇 |
外科学 | 661篇 |
综合类 | 17篇 |
一般理论 | 1篇 |
预防医学 | 581篇 |
眼科学 | 57篇 |
药学 | 480篇 |
中国医学 | 12篇 |
肿瘤学 | 317篇 |
出版年
2024年 | 6篇 |
2023年 | 31篇 |
2022年 | 101篇 |
2021年 | 205篇 |
2020年 | 107篇 |
2019年 | 199篇 |
2018年 | 227篇 |
2017年 | 141篇 |
2016年 | 140篇 |
2015年 | 154篇 |
2014年 | 250篇 |
2013年 | 318篇 |
2012年 | 491篇 |
2011年 | 513篇 |
2010年 | 309篇 |
2009年 | 263篇 |
2008年 | 400篇 |
2007年 | 377篇 |
2006年 | 364篇 |
2005年 | 352篇 |
2004年 | 333篇 |
2003年 | 299篇 |
2002年 | 275篇 |
2001年 | 88篇 |
2000年 | 93篇 |
1999年 | 95篇 |
1998年 | 58篇 |
1997年 | 51篇 |
1996年 | 40篇 |
1995年 | 41篇 |
1994年 | 28篇 |
1993年 | 11篇 |
1992年 | 29篇 |
1991年 | 18篇 |
1990年 | 29篇 |
1989年 | 24篇 |
1988年 | 17篇 |
1987年 | 17篇 |
1986年 | 16篇 |
1985年 | 12篇 |
1984年 | 15篇 |
1982年 | 5篇 |
1981年 | 5篇 |
1980年 | 4篇 |
1979年 | 8篇 |
1978年 | 10篇 |
1976年 | 4篇 |
1974年 | 5篇 |
1973年 | 5篇 |
1960年 | 3篇 |
排序方式: 共有6602条查询结果,搜索用时 0 毫秒
1.
Objective
To explore from a gender perspective the association with subjective health of the interaction between education and household arrangements within the framework of social determinants of health placed at the micro and mezzo levels.Methods
The data comes from the Spanish sample of the European Union Statistics on Income and Living Conditions for 2014. Independent logistic regression models for men and women were run to analyze the association with subjective health of the interaction between education and household arrangements. An additive model was run to assess possible advantages over the interaction approach.Results
The interaction models show a lower or even no significant effect on health of household arrangements usually negatively associated with health among individuals with high education, displaying specific patterns according to sex.Conclusions
Health profiles of women and men are more precisely drawn if both social determinants of health are combined. Among the women, the important role was confirmed of both social determinants of health in understanding their health inequalities. Among the men, mainly those with low educational achievement, the interaction revealed that the household was a more meaningful social determinant of health. This could enable the definition of more efficient public policies to reduce health and gender inequalities. 相似文献2.
Nerve growth factor (NGF) and NGF receptors were measured in cortex and hippocampus of rats treated with drugs affecting cholinergic neurotransmission. High (Kd= 0.045nM) and low (Kd= 21nM) affinity125I-NGF binding sites were present in both cortical and hippocampal membranes with hippocampus containing higher numbers of both sites than cortex. Chronic treatment of rats with the muscarinic receptor antagonist scopolamine (5 mg/kg, twice daily) decreased the density of high- and low-affinity sites by 50–90% in cortical and hippocampal membranes. These changes were seen after 7 days, but not 3 days, of scopolamine treatment. Chronic infusion of physostigmine (1 mg/kg/day) using minipumps increased the number of high- and low-affinity sites in cortex 3- and 6-fold, respectively. The changes in receptor-binding parameters induced by physostigmine were transient as they were evident after 3 days of treatment, but returned to control levels after 7 days. NGF content in cortex and hippocampus was reduced by about 50% following 7, but not 3, days of chronic physostigmine infusion. In contrast, scopolamine treatment failed to change NGF levels in the cholinergic neuronal target regions but it decreased NGF content in the septal area. The content of NGF mRNA in the cortex measured by Northern blot analysis failed to change following either scopolamine or physostigmine treatment. The results suggest that levels of NGF and NGF receptors in the target regions of cholinergic neurons are regulated by the extent of cholinergic neurotransmitter activity. 相似文献
3.
Amalia Moreno Concepción Montón Yolanda Belmonte Miguel Gallego Xavier Pomares Jordi Real 《Archivos de bronconeumologia》2009,45(4):181-185
ObjectiveThe objective of this study was to assess the causes of death and risk factors for mortality in a cohort of patients with severe chronic obstructive pulmonary disease (COPD).Patients and methodsWe studied 203 patients with severe COPD (forced expiratory volume in 1 second [FEV1] <50%), who were attended in our respiratory department day hospital (2001-2006). Clinical variables were recorded on inclusion, and clinical course and causes of death were retrospectively reviewed.ResultsThe mean (SD) age of patients was 69 (8) years and the mean FEV1 was 30.8% (8.2%). One-hundred and nine patients died (53.7%); death was attributed to respiratory causes in 72 (80.9%), with COPD exacerbation being the most frequent specific cause within this category (48.3%). During follow-up, 18.7% required admission to the intensive care unit (ICU). Survival at 1, 3, and 5 years was 80%, 53%, and 26%, respectively. The multivariate analysis showed that mortality was associated with age, stage IV classification according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD), cor pulmonale, and hospital admission during the year prior to inclusion. Need for admission to the ICU during follow-up was a factor independently associated with higher mortality.ConclusionsMortality in patients with severe COPD was high and exacerbation of the disease was one of the most frequent causes of death. Age, GOLD stage, cor pulmonale, prior admission to hospital, and need for admission to the ICU during follow-up were independent predictors of mortality. 相似文献
4.
5.
J Canet J Vallés P Vila F Vidal 《Revista espa?ola de anestesiología y reanimación》1990,37(6):366-369
Patients with morbid obesity present a series of functional and morphologic alterations and require a careful planning for anesthetic management. We report a case of a woman weighing 260 kg who was operated on twice for the treatment of her base condition. In the first operation, general anesthesia was carried out and in the second one, epidural anesthesia was conducted. Main complications included hypoxemia and hypercapnia which persisted during the first week after operation carried out under general anesthesia. 相似文献
6.
7.
Luís Mariano Isabel Vila?a Jorge Almeida Mota Garcia Maria Júlia Maciel 《Revista portuguesa de cardiologia》2007,26(3):265-270
Apical ballooning is a novel clinical entity reported in different contexts of physical and psychological stress, which is more common in middle-aged women. Of unknown etiology, the syndrome is characterized by a sudden and transient dilatation of the left ventricular apex in the absence of obstructive atherosclerotic coronary disease or evidence of myocardial necrosis, with total late recovery of ventricular function. The authors report the case of a 53-year-old woman who was admitted to the emergency room with left arm ischemia and low cardiac output, requiring ventilatory support. Left catheterization showed typical medial and apical myocardial dysfunction, with normal coronary arteries. Transesophageal echocardiography revealed a thrombus attached to the lower face of the aortic arch, which probably explained the thromboembolism of the arm but was unlikely to be the cause of the left ventricular dysfunction since there were no enzymatic or electrocardiographic signs of myocardial necrosis and normal wall motion was fully recovered. 相似文献
8.
Jordi Llorens Cristina Su ol Josep M. Tusell Eduard Rodrí guez-Farr 《Neurotoxicology and teratology》1990,12(6):607-610
The inhibition of [35S]t-butylbicyclophosphorothionate ([35S]TBPS) binding to the GABAA receptor by the insecticide γ-hexachlorocyclohexane, lindane, was studied in several brain regions and using different membrane preparation methods, both in vitro and after dosing the animals with the chemical. In the latter studies, the amount of lindane remaining in the membrane suspensions used for binding assays was determined. In vitro data showed values of IC50 from 150 to 1675 nM, varying in function of the membrane preparation method used. This may account for the discrepancies in IC50 values found in the literature. IC50 values within the range of 150–250 nM were determined using extensively washed membranes from several brain regions, so no evidence arose for brain regional differences in the affinity of lindane for the TBPS binding site. After different schedules of acute treatment with lindane, we found a manifest relationship between the extent of the observable inhibition of [35S]TBPS binding and the lindane amount remaining in the membrane suspensions used for binding assays. This relationship was in good agreement with the in vitro data, so no support for an in vivo acute regulation of the binding site was obtained. 相似文献
9.
10.
F Carmona F Fábregues R Alvarez J Vila V Cararach 《European journal of obstetrics, gynecology, and reproductive biology》1992,45(1):67-70
Morganella morganii, a gram-negative bacterium, usually infects older patients with urinary catheters, but does not commonly affect pregnant women. In this report we present a case of chorioamnionitis caused by Morganella morganii. The case was complicated by a life-threatening Adult Respiratory Distress Syndrome. 相似文献