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排序方式: 共有39条查询结果,搜索用时 31 毫秒
1.
Erika W. Wamsteker Author Vitae Rinie GeenenAuthor Vitae Pierre M.J. ZelissenAuthor Vitae Eric F. van FurthAuthor Vitae Jolein IestraAuthor Vitae 《Journal of the American Dietetic Association》2009,109(11):1903-1908
Unrealistic weight-loss goals may impede the success of weight-loss attempts. The aim of this study was to examine the frequency of unrealistic goals and their association with other patient characteristics at the start of a weight-loss program. For patients with a body mass index (calculated as kg/m2) of 30 to 35, 35 to 40, or 40 to 50, medically advised weight-loss goals were set at 10%, 15%, and 20% of current weight, respectively. Personal weight-loss goals exceeding the medically advised goal by >50% were considered unrealistic. Obesity-related beliefs were measured by the “Obesity Cognition Questionnaire” and the eating-behavior self-efficacy scale of the “Obesity Psychosocial State Questionnaire.” From September 2003 until March 2006, 90 patients were enrolled in the study, 26 men and 64 women, with a mean age of 43 years (range=18 to 68 years) and body mass indexes ranging from 30 to 50. Unrealistic goals were observed in 49% of the patients and were more frequent in younger patients (P=0.03), in patients attributing their obesity to physical causes (r=0.35, P=0.001), and in patients not attributing their obesity to behavioral causes (r=−0.28, P=0.008). This study confirms that discrepancies in weight-loss goals between obese patients and professionals occur frequently. Because unrealistic goals can hamper long-term outcomes of weight-loss programs, better outcomes could possibly be achieved by addressing unrealistic weight-loss goals before treatment. 相似文献
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Estimation of Filling and Afterload Conditions by Pump Intrinsic Parameters in a Pulsatile Total Artificial Heart
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Elena Cuenca‐Navalon Marco Laumen Thomas Finocchiaro Ulrich Steinseifer 《Artificial organs》2016,40(7):638-644
A physiological control algorithm is being developed to ensure an optimal physiological interaction between the ReinHeart total artificial heart (TAH) and the circulatory system. A key factor for that is the long‐term, accurate determination of the hemodynamic state of the cardiovascular system. This study presents a method to determine estimation models for predicting hemodynamic parameters (pump chamber filling and afterload) from both left and right cardiovascular circulations. The estimation models are based on linear regression models that correlate filling and afterload values with pump intrinsic parameters derived from measured values of motor current and piston position. Predictions for filling lie in average within 5% from actual values, predictions for systemic afterload (AoPmean, AoPsys) and mean pulmonary afterload (PAPmean) lie in average within 9% from actual values. Predictions for systolic pulmonary afterload (PAPsys) present an average deviation of 14%. The estimation models show satisfactory prediction and confidence intervals and are thus suitable to estimate hemodynamic parameters. This method and derived estimation models are a valuable alternative to implanted sensors and are an essential step for the development of a physiological control algorithm for a fully implantable TAH. 相似文献
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Christophe Van Dijck Achilleas Tsoumanis Anke Rotsaert Bea Vuylsteke Dorien Van den Bossche Elke Paeleman Irith De Baetselier Isabel Brosius Jolein Laumen Jozefien Buyze Kristien Wouters Lutgarde Lynen Marjan Van Esbroeck Natacha Herssens Said Abdellati Steven Declercq Thijs Reyniers Yven Van Herrewege Chris Kenyon 《The Lancet infectious diseases》2021,21(5):657-667
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Furet P Imbach P Noorani M Koeppler J Laumen K Lang M Guagnano V Fuerst P Roesel J Zimmermann J García-Echeverría C 《Journal of medicinal chemistry》2004,47(20):4810-4813
Proteasome inhibition is a therapeutic concept of current interest in anticancer research. We report here the design, synthesis, and biological characterization of prototypes of a new class of noncovalent proteasome inhibitors showing high activity in biochemical and cellular assays. 相似文献
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Willemijn AM. van Gemert Albertine J. Schuit Job van der Palen Anne M. May Jolein A. Iestra Harriet Wittink Petra H. Peeters Evelyn M. Monninkhof 《Breast cancer research : BCR》2015,17(1)
Introduction
Physical inactivity and overweight are risk factors for postmenopausal breast cancer. The effect of physical activity may be partially mediated by concordant weight loss. We studied the effect on serum sex hormones, which are known to be associated with postmenopausal breast cancer risk, that is attributable to exercise by comparing randomly obtained equivalent weight loss by following a hypocaloric diet only or mainly by exercise.Methods
Overweight, insufficiently active women were randomised to a diet (N = 97), mainly exercise (N = 98) or control group (N = 48). The goal of both interventions was to achieve 5–6 kg of weight loss by following a calorie-restricted diet or an intensive exercise programme combined with only a small caloric restriction. Primary outcomes after 16 weeks were serum sex hormones and sex hormone-binding globulin (SHBG). Body fat and lean mass were measured by dual-energy X-ray absorptiometry.Results
Both the diet (−4.9 kg) and mainly exercise (−5.5 kg) groups achieved the target weight loss. Loss of body fat was significantly greater with exercise versus diet (difference −1.4 kg, P < 0.001). In the mainly exercise arm, the reduction in free testosterone was statistically significantly greater than that of the diet arm (treatment effect ratio [TER] 0.92, P = 0.043), and the results were suggestive of a difference for androstenedione (TER 0.90, P = 0.064) and SHBG (TER 1.05, P = 0.070). Compared with the control arm, beneficial effects were seen with both interventions, diet and mainly exercise, respectively, on oestradiol (TER 0.86, P = 0.025; TER 0.83, P = 0.007), free oestradiol (TER 0.80, P = 0.002; TER 0.77, P < 0.001), SHBG (TER 1.14; TER 1.21, both P < 0.001) and free testosterone (TER 0.91, P = 0.069; TER = 0.84, P = 0.001). After adjustment for changes in body fat, intervention effects attenuated or disappeared.Conclusions
Weight loss with both interventions resulted in favourable effects on serum sex hormones, which have been shown to be associated with a decrease in postmenopausal breast cancer risk. Weight loss induced mainly by exercise additionally resulted in maintenance of lean mass, greater fitness, greater fat loss and a larger effect on (some) sex hormones. The greater fat loss likely explains the observed larger effects on sex hormones.Trial registration
ClinicalTrials.gov identifier: . Registered on 12 January 2012. NCT01511276Electronic supplementary material
The online version of this article (doi:10.1186/s13058-015-0633-9) contains supplementary material, which is available to authorized users. 相似文献8.
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Crooijmans HJ Laumen AM van Pul C van Mourik JB 《Clinical orthopaedics and related research》2009,467(4):909-916
Preoperative templating is an important part of a THA. The ability to accurately determine magnification of the hip on the
radiograph and apply identical magnification to the radiograph and template will improve accuracy of preoperative templating
of THA. We designed a templating method using a new way of determining the hip magnification with a linear relationship between
magnification of the hip and the reference object on top of the pubis symphysis; the relationship was determined on 50 radiographs.
We then compared our method with two other templating methods: an analog method assuming an average hip magnification of 15%
and a digital method determining the hip magnification with a one-to-one relationship between the reference object and the
hip. All methods were reproducible. Uniform undersizing occurred when templating with the digital method based on the one-to-one
relationship; the analog method best predicted the implanted prosthesis size, closely followed by our new digital templating
method; the new method will be particularly applicable for preoperative THA when analog methods are replaced by digital methods.
Each author certifies that he or she has no commercial associations (eg, consultancies, stock ownership, equity interest,
patent/licensing arrangements, etc) that might pose a conflict of interest in connection with the submitted article.
Each author certifies that his or her institution either has waived or does not require approval for the human protocol for
this investigation and that all investigations were conducted in conformity with ethical principles of research. 相似文献