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排序方式: 共有322条查询结果,搜索用时 15 毫秒
1.
Erythropoietin deficiency and relative resistance cause anaemia in post-renal transplant recipients with normal renal function 总被引:6,自引:2,他引:4
Nampoory M. R. N.; Johny K. V.; Al-Hilali N.; Seshadri M. S.; Kanagasabhapathy A. S. 《Nephrology, dialysis, transplantation》1996,11(1):177-181
BACKGROUND: Following successful renal transplantation, blood erythropoietin(Epo) levels peak in two phases during the first 23 months,and blood haemoglobin/haematocrit (Hb/Hct) levels are restoredto normal in a period of 26 months. However, some transplantrecipients continue to remain anaemic in spite of normal graftfunction and in the absence of recognizable causes. The roleof endogenous Epo production in the causation of anaemia insuch patients is poorly understood and has been investigatedin this study. METHODS: Twenty-three post-renal transplant recipients with stable normalrenal function were studied. Eleven of these patients had normalHb/Hct levels (group 1) and served as control for the rest 12patients with anaemia (group 2). Patients included in group2 had no readily recognizable cause for their anaemia. Otherlaboratory and clinical findings were similar in both groups.Patients with erythrocytosis were excluded. Serum Epo levelswere measured in all patients. Five patients in group 2 weretreated with recombinant human erythropoietin (rHuEpo) and theirerythropoietic response was assessed. rHuEpo was discontinuedwhen the target Hb/Hct levels (lowest normal range) were achievedand the patients were followed up for a further period of 912months. RESULTS: Five patients in group 1 had normal expected serum Epo levelswhereas the other six patients had inappropriately high serumEpo levels with respect to their Hb/Hct status suggestive ofrelative Epo resistance. Serum Epo levels in allpatients except two in group 2 were low indicative of Epodeficiency. The two exceptional patients in group 2 hadhigher serum Epo levels in the presence of anaemia suggestiveof relative Epo resistance. All five patients treated with rHuEpo responded adequately byachieving normal Hb/Hct levels. Three of them were originallyEpo deficient and they reached target Hb/Hct levelsin a mean period of 4 weeks, requiring a mean cumulative rHuEpodose of 428.3 units/kg. The other two patients with higher initialserum Epo levels, and considered to be Epo resistant,required an average of 11 weeks of treatment and a mean cumulativerHuEpo dose of 1582.5 units/ kg, indicating an increased Epodemand. On cessation of therapy the Hb/Hct levels fell in allfive patients to pretreatment values in 6 months. CONCLUSIONS: There are important variations in the endogenous Epo productionin renal transplant patients with normal renal function, thecause of which is not clear. Epo deficiency and relative Eporesistance play a causative role for anaemia in some post-renaltransplant recipients with stable normal renal function. Theyrespond adequately to rHuEpo administration. 相似文献
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F. Fouad K. Johny. S. Kaaba T. O. Alkarmi P. SHARMA S. Al-Harbi 《International journal of immunogenetics》1994,21(1):11-14
HLA alleles were studied in Kuwaiti patients with Systemic lupus erythematosus (SLE). Although significant association of B5, B8, and DR3 has been reported in the literature, the most common phenotype for our patients is A3, DR2 as susceptible alleles and DQ1 as a protective gene. 相似文献
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Anastasios Roumeliotis MD Bimmer E. Claessen MD PhD Samantha Sartori PhD Davide Cao MD Hanbo Qiu Anton Camaj MD MS Johny Nicolas MD Rishi Chandiramani MD Ridhima Goel MD Mauro Chiarito MD Rebecca Torguson MPH Joseph Sweeny MD Nitin Barman MD Prakash Krishnan MD Annapoorna Kini MD Samin K Sharma MD George Dangas MD PhD Roxana Mehran MD 《Catheterization and cardiovascular interventions》2021,98(4):E494-E500
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Verschakelen JA 《Seminars in respiratory and critical care medicine》2003,24(5):473-488
Small airways disease (SAD) is defined as a pathologic condition in which the small conducting airways are affected either primarily or as part of other pulmonary changes. Diagnosis is often difficult because the many histopathologic subtypes that have been described often lack obvious clinical or imaging correlates and because widespread involvement is needed before clinical symptoms and abnormalities on pulmonary function testing occur. High-resolution computed tomography (HRCT) can be helpful to detect, characterize, and quantify small airways involvement. These airways may become visible directly when inflammation of the bronchiolar wall and accompanying exudates develop. Obstruction of the small airways may be detected indirectly by HRCT when it causes regional underventilation resulting in reduced perfusion. This article discusses the direct and indirect HRCT signs of small airways involvement and, based on the fundamental differences between these signs, gives a short review of the HRCT features of the most important diseases that can affect the small airways. 相似文献