Elevation of gastric pH heals peptic oesophagitis - A role for omeprazole

The aim of this study was to investigate the hypothesis that the prolonged and substantial elevation of gastric pH which can be achieved with the antisecretory agent omeprazole will result in healing of peptic oesophagitis. Eight patients with erosive or ulcerative peptic oesophagitis were treated with omeprazole (30 mg daily) for 8 weeks. Complete healing occurred in seven patients after 8 weeks of omeprazole therapy. Only a small area of residual ulceration persisted in one unhealed patient. Heartburn resolved within the first 2 weeks of therapy in all but one patient. Specific food intolerances also were eliminated in most cases. Post-prandial oesophageal pH monitoring during omeprazole administration showed abolition of acid reflux episodes (pH < 4). This effect appeared to be due solely to the antisecretory effect of omeprazole, since motility measurements demonstrated a continued high frequency of reflux while concurrent gastric pH monitoring showed sustained elevation of gastric pH above 4. These results support the hypothesis that a prolonged and potent inhibition of gastric acid secretion renders refluxed gastric juice sufficiently innocuous to allow healing of severe peptic oesophagitis.     

纠正10个做爱错觉

作为男人，让他们静下心来读网络里两性频道的文字，也许，还不如看三级片里日本AV女优的夸张表演更有味，哪怕它们所表达的信息是夸张而不真实的。你对目前的做爱质量感觉怎么样？是否希望尝试沟通来改变？因为——你“快乐”，所以我“快乐”。     

Policies to halve smoking deaths

Britain still has amongst the highest mortality rates in the world for all the major smoking diseases. A third of all adults smoke cigarettes regularly and smoking causes one third of UK deaths in middle age. This paper discusses factors related to changes in smoking levels and concludes that without the intervention of government policies, smoking prevalence and the amount smoked per smoker is likely lo rise, particularly for young people. Measures to reduce smoking are surveyed and estimates made of the maximum likely effects from health education, advertising control, general practitioner smoking cessation advice and public and work place policies. A pricing policy is suggested which, with the other policies could reduce cigarette consumption by a half so that only one in five adults smoke by the year 2000. Predictions are made of the effect of this policy package on lives and life years saved. Within twenty five years there would be 50 000 fewer deaths from smoking and half a million life years saved annually. This would rise to two thirds of a million within forty years. Deaths from lung cancer would fall by 38%. The quality of these life years saved would tend to the average for their age.     

Aortic root abscess in Actinobacillus actinomycetemcomitans endocarditis: non invasive diagnosis and successful outcome following early surgery

The case described is the first in which Actinobacillus actinomycetemcomitansendocarditis affecting the aortic valve was complicated by aorticroot abscess formation. The diagnosis was supported by the developmentof complete left bundle branch block, the presence of pericarditisand the two-dimensional echocardiographic appearance. Earlysurgery was performed and the diagnosis confirmed. The patientmade full recovery.     

Opioid Use and Burglary

In order to investigate the extent of the involvement of opioid users in residential burglary offences estimates were made of the proportions of persons who were notified addicts amongst all those prosecuted in 1983 and convicted of the offence by courts in four London and two Merseyside Petty Sessional Divisions (PSDs). The proportions ranged from 1% to 15% in the Merseyside PSDs and from 3% to 11% in the London PSDs. The factors likely to account for these variations, including differences in police clear-up rates for the offence, are discussed. It is concluded that the presence of relatively large numbers of young male opioid users in a local population may well contribute to increases in the number of residential burglary offences in the area.     

A comparison of doctors' practice in notifying addicts to the Home Office and reporting them to the North Western Drug Misuse Database

Doctors have been required to notify named addict patients to the Chief Medical Officer at the Home Office since 1968, and since 1990 have been encouraged to report voluntarily all their drug misusing patients to anonymized NHS regional databases. The North Western Drug Misuse Database, set-up for research purposes in 1985, was the forerunner of these databases. Compliance by doctors from three North Western District Health Authorities with both data collection systems between 1986 and 1989 was assessed by matching the names of notified addicts with the attributors of individuals reported to the NWDMD as users of notifiable drugs. By 1989 72% of addicts notified were also reported to the NWDMD although doctors working in hospital general departments still tended only to notify them. There was no evidence that particular general practitioners consistently did not notify their addict patients while reporting them to the NWDMD. The findings suggest that it will take some time for doctors to become accustomed to reporting all their drug misusing patients to the regional databases as well as notifying to Home Office those who met the notification criteria.     

The Effects of Neurotoxicants on Kindling and Kindled Seizures

The Effects of Neurotoxicants on Kindling and Kindled Seizures.JOY, R. M. (1985). Fundam. Appl. Toxicol. 5,41–65. Theapplication of a constant-amplitude electrical stimulation tomany parts of the brain leads to the expression of progressivelymore severe epileptiform responses. The process of acquisitionis termed kindling, and the acquired response is termed thekindled seizure. This state has been used in a number of importantways including the modeling of human epilepsy and behavioraldisorders, the testing of drugs for anticonvulsant effects,and, more recently, the examination of hyperexcitability statesinduced by pesticides and other environmental chemicals. Thisreport discusses attributes of kindling and kindled seizures,examines possible mechanisms responsible for them, and summarizesdrug and chemical effects on them. Kindling is powerfully acceleratedby exposures to only a few substances, among the most effectiveof which are the chlorinated hydrocarbon insecticides, lindaneand dieldrin. An analysis of the acceleration of kindling producedby lindane suggests that the threshold concentration in thenervous system for kindling enhancement is approximately 0.4µg/g (1.4 x 10^–9 mol/g).