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1.
PHILLIPS D.I.W.; COOPER C.; FALL C.; PRENTICE L.; OSMOND C.; BARKER D.J.P.; SMITH B. REES 《QJM : monthly journal of the Association of Physicians》1993,86(4):247-253
To determine whether fetal and infant growth could influencesusceptibility to autoimmune disease in adults, the occurrenceof thyroid autoantibodies and autoimmune thyroiditis was studiedin 305 women, aged 6071, born in Hertfordshire and forwhom details of birth weight, infant growth, and feeding wereroutinely recorded. Thyroglobulin autoantibody was detectedin 37% of the women, thyroid peroxidase autoantibody in 41%,and autoimmune thyroiditis, defined as biochemical or clinicalhypothyroidism in association with thyroid autoantibodies, in5.6%. The proportion of women with thyroglobulin and thyroidperoxidase auto antibodies fell with increasing birth weightbut was not related to weight at 1 year of age or the methodof infant feeding. The prevalence of both autoantibodies rosewith increasing adult body mass index but fell as the waistto hip ratio increased. These results demonstrate the importance of early environmentin determining the susceptibility to autoimmune thyroid disease.The contrasting effects of adult body mass index and waist tohip ratio on antibody prevalence could be explained by theirassociations with different hormonal environments. 相似文献
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Improvement in quality of cryopreserved human spermatozoa by swim-up before freezing 总被引:4,自引:0,他引:4
F. PÉREZ-SÉNCHEZ T. G. COOPER C. H. YEUNG E. NIESCHLAG 《International journal of andrology》1994,17(3):115-120
Selecting a population of spermatozoa by the swim-up technique yields, after freezing and thawing, a population of cells that contains proportionally more spermatozoa which are morphologically normal, fewer spermatozoa with damaged tail membranes, and a greater percentage of progressively motile spermatozoa with greater velocities and amplitudes of head displacement than those obtained after freezing and thawing the same semen samples in the normal way. This pattern was found for the semen from 10 patients and five volunteers. However, the cells selected by swim-up were as susceptible to the stresses caused by freezing and thawing as unselected spermatozoa in the original semen sample, and the improvement came from the better quality of the initial sample. 相似文献
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JOSHUA W. SALVIN MD MPH PETER C. LAUSSEN MBBS RAVI R. THIAGARAJAN MBBS MPH 《Paediatric anaesthesia》2008,18(12):1157-1162
Extracorporeal membrane oxygenation (ECMO) is increasingly used to support postcardiotomy cardiorespiratory failure in children with congenital heart disease. We report on survival outcomes and factors associated with survival for postcardiotomy ECMO patients. 相似文献
7.
COOPER R. A.; MADDINENI V. R.; MIRAKHUR R. K.; WIERDA J. M. K. H.; BRADY M.; FITZPATRICK K. T. J. 《British journal of anaesthesia》1993,71(2):222-226
We have studied the onset and duration of action and pharmacokineticsof rocuronium bromide (Org 9426) during anaesthesia with nitrousoxide, fentanyl and isoflurane after a single bolus dose ofrocuronium 0.6 mg kg1 in nine patients with chronic renalfailure requiring regular haemodialysis, and in nine healthycontrol patients. Blood samples were collected over 390 minand concentrations of rocuronium and its putative metabolitesmeasured using HPL C. Onset time for maximum block, durationof clinical relaxation (T125) and recovery index, were 61 (SD25.0) s and 65 (16.4) s, 55 (26.9) min and 42 (9.3) min and28 (12.3) min and 19 (8.8) min, respectively, for patients withand without renal failure. The time for TOF ratio to returnspontaneously to 0.7 was 99 (41.1) min and 73 (24.2) min, respectively,in the two groups. None of these differences was significant.The pharmacokinetic data were best described by a three-exponentialequation. There were significant differences between patientswith and without renal failure in the rates of clearance (2.5(1.1) ml kg1 min1 and 3.7(1.4) ml kg1 min1respectively) and the mean residence times (97.1 (48.7) minand 58.3(9.6) min) (P<0.05). The differences in other kineticparameters were not significant. We conclude that the effectsof rocuronium may be prolonged in patients with renal disease,because of a decreased clearance of the drug. 相似文献
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Prior research indicates that alcohol-related outcome expectancies represent important etiological factors in the understanding of alcohol use/abuse. Although current multidimensional measures assess several substantively different domains of alcohol-related outcome expectancies, there is growing evidence that they may not possess adequate levels of discriminant validity. Therefore, the present study sought to examine whether reliable between-person differences exist in the ability to differentiate among alcohol expectancy domains. The focus of the study was on three sets of intrapersonal characteristics: cognitive resources, cognitive constraints, and alcohol-related experience. Data were collected via household interviews with a random sample of 1125 adults. Multiple regression analysis revealed that higher levels of cognitive resources were associated with increasing levels of differentiation among alcohol expectancy domains. Results are discussed in terms of implications for the development of new or revised multidimensional alcohol expectancy questionnaires. Directions for future research are also discussed. 相似文献
9.
IS THE HIP INVOLVED IN GENERALIZED OSTEOARTHRITIS? 总被引:1,自引:1,他引:0
Elbow pain is a common complaint and elbow hyperostosis a frequentradiological condition. However, little is known about the associationbetween the clinical and radiological findings. To evaluatethe relationship between spinal and extraspinal hyperostoticfeatures and the clinical relevance of elbow hyperostosis wehave performed the first controlled, double-blinded study of85 hospitalized probands, 33 with and 52 without thoracospinalhyperostosis on lateral chest X-ray. Elbow and shoulder hyperostosiswere graded on bilateral standard radiographs. Elbow pain wasassessed by an interviewer using a standardized questionnaireand extraskeletal causes of elbow pain were recorded. The prevalenceof elbow hyperostosis was increased in cases with thoracospinalhyperostosis compared to controls (82% versus 58%, X2 = 5.32,P<0.025, n = 85, odds ratio (OR) 3.30 (95% Cl 1.169.35)).Similarly, the prevalence of elbow hyperostosis was increasedin cases with shoulder hyperostosis compared to controls (83%versus 60%, x2 = 4.51, P<0.05, n = 84, OR = 3.20 (95% CI1.069.66)), emphasizing the multifocal nature of hyperostoticfeatures. Elbow pain was only slightly more prevalent in caseswith elbow hyperostosis compared to controls (21% versus l3%,x2 = 0.75, NS, OR = 1.84 (95% CI 0.467.44)). We concludethat elbow hyperostosis is a radiological finding of doubtfulclinical relevance. KEY WORDS: Hyperostosis, Spinal osteophytosis, Elbow, Pain 相似文献
10.
Inhibition of the Mixed Lymphocyte Culture Response by Antibody Following Successful Human Renal Transplantation 总被引:7,自引:0,他引:7
Immunoglobulin G, appearing after several months in the serum of a recipient of a successful kidney transplant from a closely matched sibling donor, was demonstrated to progressively inhibit unidirectional mixed lymphocyte cultures when donor lymphocytes were used either in responding or stimulating cell populations. The active recipient IgG had no effect in cultures in which donor cells were not used, nor did IgG obtained from other individuals show nonspecific inhibitory effects on cultures containing donor cells. It is suggested that the MLC inhibitory immunoglobulin may serve an immunoregulatory function after renal transplantation. 相似文献