排序方式: 共有6条查询结果,搜索用时 15 毫秒
1
1.
HITOSHI TAKAGI MASAHIRO UEHARA SATORU KAKIZAKI HITOMI TAKAHASHI JIROU TAKEZAWA KENJI KABEYA KEN SATOH AKIRA KOJIMA SHUICHI SAITO TATSUHIKO MATSUMOTO YOSHIAKI HASHIMOTO TAKEHIKO ABE TOSHIHIKO YAMADA KAZUKO KONAKA RYUYA SHIMODA HISASHI TAKAYAMA KEN TAKEHARA TAKEAKI NAGAMINE MASATOMO MORI 《Journal of gastroenterology and hepatology》1998,13(3):238-243
Accidental transmission of contagious pathogens, especially hepatitis C virus (HCV), by needlestick or other means as an occupational hazard for medical staff is of concern. We retrospectively analysed cases of work-related accidental injury with pathogens such as hepatitis B virus (HBV), HCV, syphilis and human immunode?ciency virus (HIV) reported to the centres for disease control at 15 hospitals (total 5776 beds) in the Gunma prefecture, Japan, from December 1990 to August 1993 (24.7 months). There were 416 such cases (16.8 cases/month), with an incidence of 0.2–3.5 accidents per month per hospital. Such accidents occurred in 297 (71.2%) nurses, 98 (23.5%) medical doctors, 13 (3%) laboratory technicians, four (1.0%) hospital maintenance workers, one (0.2%) assistant nurse, one secretary and two others. There were 323 (77.6%) injuries caused by needlestick, 42 (10.1%) from suture needles or surgical knife cuts, 17 (4.1%) from blood splatters from patients into the eyes or mouth, 10 (2.4%) from contact with injured skin and 24 (5.8%) simple skin contacts. Of the pathogens, 60.3% were HCV, 22.6% HBV, 5.8% syphilis, 0.7% HIV and 10.6% were of unknown origin. Four cases (1.6%) of HCV infection were found and treated with one or two courses of interferon therapy, and HCV was subsequently cleared. All four patients were cured with interferon therapy. None of the HBV-injured cases resulted in infection, possibly because of prophylaxis with HB immunoglobulin and HB vaccine. No HIV or syphilis infection was contracted. In summary, chronic HCV infection acquired as an occupational hazard can be cured by appropriate treatment, such as with interferon, after early detection of the infection. 相似文献
2.
3.
A 5 year old female developed femoral pain, fever, and hemorrhagic tendency. She was diagnosed as having acute promyelocytic leukemia (APL). Approximately 2 weeks after the administration of all-trans retinoic acid (ATRA), she developed a high fever, edema, and respiratory distress which met the criteria for retinoic acid syndrome. At first, we tried to treat the patient with oral corticosteroid, however, this approach was unsuccessful. Considering the worsening of her condition, we then chose to administer a large dose of intravenous dexamethasone therapy for 3 days. Immediately after this therapy, she became afebrile, respiratory distress and edema disappeared, and there was a general improvement of the symptoms. All-trans retinoic acid at the reduced dose of 25 mg/m2, was continued for an additional 6 weeks and then discontinued. Since the cessation of dexamethasone and ATRA, there has been no relapse of APL in this patient. Although based on only one case, we recommend the intravenous high-dose dexamethasone pulse therapy (13 mg/m2 per day, for 3 days) for treating retinoic acid syndrome which develops in pediatric APL patients treated with ATRA. 相似文献
4.
Keisuke SATO Yoshihiro TOMINAGA Fumihiko ICHIKAWA Kazuharu UCHIDA Jun-ichi TAKEZAWA Takeshi TSUCHIYA Noboru KUBODERA Hiroshi TAKAGI 《Nephrology (Carlton, Vic.)》1998,4(3):177-182
SUMMARY: 22-oxa-calcitriol (OCT), a vitamin D analogue, suppresses parathyroid hormone (PTH) secretion and has less calcaemic activity than 1,25-dihydroxyvitamin D3 [1,25(OH)2 D3 ] in vivo. In this study, we evaluated the effect of OCT on PTH secretion in vitro using human hyperplastic parathyroid tissue obtained during surgery for advanced renal hyperparathyroidism and normal bovine parathyroid glands to compare the effects of 1,25(OH)2 D3 . 22-oxa-calcitriol suppressed PTH secretion by nodular hyperplastic parathyroid tissue and normal bovine tissue in a dose dependent manner, the same as 1,25(OH)2 D3 . We showed the additive effect of extracellular calcium level on suppression of PTH secretion by OCT and 1,25(OH)2 D3 . These results suggest that OCT suppresses PTH secretion, the same as 1,25(OH)2 D3 not only in normal parathyroid cells but also on hyperplastic parathyroid cells. 相似文献
5.
Shigeru YUMITA Hiroshi SEKINO Sshigeki YAMAUCHI Junichi TAKEZAWA 《Nephrology (Carlton, Vic.)》1996,2(5):339-343
Summary: The present study was designed to determine the criterion for 1,25-dihydroxyvitamin D3 (1,25 (OH)2D3) loading test in normal subjects and haemodialysis patients. Fourteen normal subjects were administered 1.0 μg of 1,25(OH)2D3 per os and serum 1,25(OH)2D was monitored every hour up to 6 h afterwards under conditions of overnight fasting, and six haemodialysis patients were administered 2.0 μg of 1,25(OH)2D3 per os and serum 1,25(OH)2D was monitored every 2 h up to 12 h afterwards. Peak time of serum 1,25 (OH)2D varied between 2 and 5 h after administration in normal subjects. However, there was a good correlation between the maximum increment of 1,25(OH)2D (maxΔ1,25(OH)2D) and the increment at 4 h after administration (Δ1,25(OH)2D(4 h)). the peak time of Δ1,25(OH)2D in six haemodialysis patients was also at 4 h after administration. From these observations, Δ1,25(OH)2D(4 h) was evaluated in subsequent studies. Twenty-six normal subjects and 24 haemodialysis patients were administered 0.5–2.0 μg of 1,25(OH)2D3 per os, according to their bodyweights, under conditions of overnight fasting. Blood samples were drawn for measuring 1,25(OH)2D prior to and 4 h after administration. Δ1,25(OH)2D(4 h) showed good correlation with the dose of 1, 25 (OH)2D3 adjusted by bodyweight (ng/kg bodyweight). the ratio of Δ1,25(OH)2D(4 h) and adjusted dose of 1,25(OH)2D3 was more than 2.0 in all normal subjects (range: 1.97?2.89, mean ± SD: 2.38 ± 0.287). Moreover, the ratio of Δ1,25(OH)2D(4 h) and adjusted dose of 1,25(OH)2D3 showed a good reproducibility (CV%= 5.7 Δ 0.32, n=5), and did not depend on the administered dose of 1,25(OH)2D3, suggesting that this ratio is a good parameter for the intestinal absorption of 1,25(OH)2D3. In haemodialysis patients, the mean ratio of Δ1,25 (OH)2D(4 h) and adjusted dose of 1,25(OH)2D3 was 2.14 Δ 0.489, which was not significantly different from the ratio in normal subjects, suggesting that, fundamentally, there was no impairment of intestinal absorption of 1,25(OH)2D3 in these patients. However, low ratios of Δ(4 h) and the dose of 1,25(OH)2D3 with low basal levels of 1,25(OH)2D were observed in some patients (less than 1.5 in four patients), suggesting that there exist haemodialysis patients with malabsorption of 1,25(OH)2D3. From these results, the criterion for normal response in 1,25(OH)2D loading test was proposed, namely, that the ratio of Δ1,25(OH)2D(4 h) and adjusted dose of 1,25(OH)2D3 be more than 2.0. 相似文献
6.
1