全文获取类型
收费全文 | 1922篇 |
免费 | 126篇 |
国内免费 | 18篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 42篇 |
妇产科学 | 9篇 |
基础医学 | 218篇 |
口腔科学 | 58篇 |
临床医学 | 129篇 |
内科学 | 536篇 |
皮肤病学 | 61篇 |
神经病学 | 151篇 |
特种医学 | 72篇 |
外科学 | 409篇 |
综合类 | 8篇 |
预防医学 | 21篇 |
眼科学 | 54篇 |
药学 | 85篇 |
中国医学 | 1篇 |
肿瘤学 | 211篇 |
出版年
2023年 | 21篇 |
2022年 | 32篇 |
2021年 | 64篇 |
2020年 | 36篇 |
2019年 | 39篇 |
2018年 | 56篇 |
2017年 | 45篇 |
2016年 | 52篇 |
2015年 | 56篇 |
2014年 | 73篇 |
2013年 | 57篇 |
2012年 | 107篇 |
2011年 | 94篇 |
2010年 | 61篇 |
2009年 | 38篇 |
2008年 | 76篇 |
2007年 | 87篇 |
2006年 | 86篇 |
2005年 | 97篇 |
2004年 | 123篇 |
2003年 | 119篇 |
2002年 | 113篇 |
2001年 | 38篇 |
2000年 | 43篇 |
1999年 | 37篇 |
1998年 | 24篇 |
1997年 | 24篇 |
1996年 | 13篇 |
1995年 | 19篇 |
1994年 | 13篇 |
1993年 | 9篇 |
1992年 | 29篇 |
1991年 | 21篇 |
1990年 | 23篇 |
1989年 | 22篇 |
1988年 | 22篇 |
1987年 | 32篇 |
1986年 | 15篇 |
1985年 | 15篇 |
1984年 | 10篇 |
1983年 | 8篇 |
1982年 | 12篇 |
1981年 | 7篇 |
1980年 | 8篇 |
1978年 | 7篇 |
1976年 | 11篇 |
1974年 | 10篇 |
1972年 | 9篇 |
1971年 | 6篇 |
1969年 | 7篇 |
排序方式: 共有2066条查询结果,搜索用时 15 毫秒
1.
2.
3.
Pharynx and oesophagus evaluation during the swallow using helical computerized tomography. 总被引:2,自引:0,他引:2
PURPOSE: Videofluorography (VF) and endoscopy are commonly used for dynamic imaging (DI) of pharyngeal swallowing but do not offer transverse plane (TP) information. The aim of the present study was to evaluate helical computerized tomography (HCT) to measure the DI capability pharyngeal swallowing in the TP. METHODS: The HCT scan technique used was a single-slice cine mode with scan times of 100 ms. All 15 subjects were studied supine during dry swallow, swallowing of barium sulphate jelly and 3, 10, 15 or 20 ml of a 40% barium sulphate solution. Nine subjects repeated the test twice at more than 1 week's interval to determine the test-retest reliability. RESULTS: Swallowing leads to closure of the vocal folds, pharyngeal constriction and narrowing of the piriform sinuses allowing jelly passage between the sinuses. Laryngeal elevation then occurs with the opening of the pharyngoesophageal segment (PES). Swallowing a bolus of 20 ml produced the maximum anteroposterior and transverse diameters as well as the maximum opening area of the PES. The test-retest intraclass correlation coefficients with liquid deglutition ranged from 0.86 to 0.98. CONCLUSIONS: This study shows that HCT enables visualization of TP of PES complementing VF or endoscopic swallowing studies. 相似文献
4.
In an open trial, 1841 patients were treated with mainly 1 g of cefminox twice a day in adults or 20-30 mg/kg three or four times a day in children for up to 14 days. The clinical efficacy was assessed in 1560 patients (1256 adults, 304 children) and the efficacy rates were as follows: 82.3% in respiratory tract infections (n:525), 85.7% in biliary tract infections (n:87), 66.4% in urinary tract infections (n:509), 92.1% in gynaecological infections (n:126), 88.1% in peritonitis (n:84), 74.9% in all infections (n:1560). The overall bacterial response rates in single infections were 81.5% (81.5% for Staphylococcus aureus, 98.4% for Escherichia coli, 98.6% for Haemophilia influenzae and 38.8% for Pseudomonas aeruginosa). The safety of cefminox was assessed in 1831 patients. Adverse side-effects were reported in 35 patients (1.9%), the most frequent being rash. 相似文献
5.
Takashi Matsuo Itaru Kyoraku Kazutaka Shiomi Seiichiro Sugimoto Huai-Ying Zheng Masamitsu Nakazato 《Clinical neurology》2007,47(1):27-31
A 53-year-old man with adult T-cell leukemia (ATL) developed progressive left hemiparesis and left homonymous hemianopsia. Magnetic resonance imaging (MRI) one month later showed multiple high-intensity lesions in the white matter of both occipital lobes, with predominance in the right side. Detection of JCV genome with polymerase chain reaction in his cerebrospinal fluid subsequently confirmed the diagnosis of progressive multifocal leukoencephalopathy (PML). He was admitted to our hospital. The serum level of soluble interleukin-2 receptor in the patient increased, and both edema and new Gd-enhanced lesions were observed in the cortex of the occipital lobe. He was treated with systemic administrations of Pirarubicin. Cyclophosphamide, and Prednisolone. as well as intrathecal injection of Methotrexate and Cytarabine. Although these treatments temporarily alleviated the symptoms of PML. the ATL spread to the liver and kidney. He died of multiple organ failure. Analysis of his JCV genes revealed that there were three types of rearrangements in the regulatory domains of the JCV genes. All three types lacked the domain B. and two had duplicate domain A. This is the first report of the simultaneous detection of three different types of rearrangements in JCV genes in a single patient. It has been reported that white-matter lesions caused by typical PML are not enhanced in Gd-MRI. However. the lesions seen in this patient were enhanced in Gd-MRI. Such enhancement might be attributable to the modification of the lesions through the direct invasion of ATL cells to the central nervous system. 相似文献
6.
Itsuo Yokoyama Tadamasa Yoneda Itaru Ichimura Shigehisa Kitagawa Yoshiki Okazaki Hiroshi Takagi 《Surgery today》1986,16(6):460-463
In seven patients undergoing right hemicolectomy for benign or malignant diseases, latero-lateral end anastomoses were made
using stapling devices, LS (linear stapler) and GIA (gastrointestinal anastomosis). As no complications directly related to
the anastomosis occurred, we conclude that anastomosis using stapling devices for right hemicolectomy is a safe and rapid
procedure. 相似文献
7.
We report a case of cortical reflex myoclonus in adult onset Huntington's disease (HD). The patient is a 51-year-old woman. Chorea and myoclonus were observed on her face and extremities. Neurophysiological tests showed C reflex and abnormal waves preceding myoclonus by jerk-locked back averaging method but no giant somatosensory evoked potential. Gene analysis revealed the prolongation of CAG repeats (13/44) in IT15 gene. Oral administration of clonazepam was transiently effective for myoclonus. We should inscribe that the cortical reflex myoclonus may exceptionally manifest in HD. 相似文献
8.
9.
Pharmacologic preconditioning effects: Prostaglandin E1 induces heat-shock proteins immediately after ischemia/reperfusion of the mouse liver 总被引:1,自引:0,他引:1
Ken-ichi Matsuo M.D. Shinji Togo M.D. Ph.D. Hitoshi Sekido M.D. Ph.D. Tomoyuki Morita M.D. Ph.D. Masako Kamiyama Ph.D. Daisuke Morioka M.D. Ph.D. Toru Kubota M.D. Ph.D. Yasuhiko Miura M.D. Ph.D. Kuniya Tanaka M.D. Ph.D. Takashi Ishikawa M.D. Ph.D. Yasushi Ichikawa M.D. Ph.D. Itaru Endo M.D. Ph.D. Hitoshi Goto M.D. Ph.D. Hiroyuki Nitanda M.D. Ph.D. Yasushi Okazaki M.D. Ph.D. Yoshihide Hayashizaki M.D. Ph.D. Hiroshi Shimada M.D. Ph.D. 《Journal of gastrointestinal surgery》2005,9(6):758-768
Prostaglandin E1 (PGE1) has several potential therapeutic effects, including cytoprotection, vasodilation, and inhibition of platelet aggregation. This study investigates the protective action of PGE1 against hepatic ischemia/reperfusion injury in vivo using a complementary DNA microarray. PGE1 or saline was continuously administered intravenously to mice in which the left lobe of the liver was made ischemic for 30 minutes and then reperfused. Livers were harvested 0, 10, and 30 minutes postreperfusion. Messenger RNA was extracted, and the samples were labeled with two different fluorescent dyes and hybridized to the RIKEN set of 18,816 full-length enriched mouse complementary DNA microarrays. Serum alanine aminotransferase and aspartate aminotransferase levels at 180 minutes postreperfusion were significantly lower in the PGE1-treated group than in the saline-treated group. The cDNA microarray analysis revealed that the genes encoding heat-shock protein (HSP) 70, glucose-regulated protein 78, HSP86, and glutathione S-transferase were upregulated at the end of the ischemic period (0 minutes postreperfusion) in the PGE1 group. Our results suggested that PGE1 induces HSPs immediately after ischemia reperfusion. HSPs might therefore play an important role in the protective effects of PGE1 against ischemia/reperfusion injury of the liver. 相似文献
10.
The effect of spontaneous respiration on esophageal variceal flow was evaluated using 5 MHz color flow Doppler echography. Twenty-one patients with esophageal varices, of whom 19 had liver cirrhosis (95%), were examined with a convex array transesophageal transducer. The direction and velocity of the variceal flow during inhalation and exhalation could be inferred from the color, its brightness or the Doppler time-velocity spectrum. The mean intravariceal flow velocity was significantly higher during inhalation (20.6 cm per sec) than in exhalation (11.5 cm per sec; p less than 0.01). The direction of intravariceal flow at any given point did not change throughout the respiratory cycle. However, a combination of real-time color flow imaging and the doppler time-velocity spectrum revealed that, when the sampling point was near the peak of the curve of the varix, the spectrum falsely indicated reversal of direction between inhalation and exhalation. This semiinvasive method, which yields anatomical and physiological information simultaneously, appears to be very useful for the study of variceal flow. 相似文献