全文获取类型
收费全文 | 2551篇 |
免费 | 178篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 25篇 |
儿科学 | 51篇 |
妇产科学 | 114篇 |
基础医学 | 372篇 |
口腔科学 | 215篇 |
临床医学 | 248篇 |
内科学 | 520篇 |
皮肤病学 | 33篇 |
神经病学 | 232篇 |
特种医学 | 102篇 |
外科学 | 270篇 |
综合类 | 5篇 |
预防医学 | 231篇 |
眼科学 | 19篇 |
药学 | 164篇 |
中国医学 | 11篇 |
肿瘤学 | 123篇 |
出版年
2023年 | 21篇 |
2022年 | 56篇 |
2021年 | 98篇 |
2020年 | 75篇 |
2019年 | 74篇 |
2018年 | 78篇 |
2017年 | 52篇 |
2016年 | 80篇 |
2015年 | 79篇 |
2014年 | 103篇 |
2013年 | 145篇 |
2012年 | 216篇 |
2011年 | 222篇 |
2010年 | 93篇 |
2009年 | 69篇 |
2008年 | 142篇 |
2007年 | 139篇 |
2006年 | 123篇 |
2005年 | 107篇 |
2004年 | 81篇 |
2003年 | 69篇 |
2002年 | 76篇 |
2001年 | 46篇 |
2000年 | 62篇 |
1999年 | 35篇 |
1998年 | 15篇 |
1997年 | 15篇 |
1996年 | 19篇 |
1995年 | 14篇 |
1994年 | 7篇 |
1993年 | 11篇 |
1992年 | 33篇 |
1991年 | 23篇 |
1990年 | 14篇 |
1989年 | 24篇 |
1988年 | 20篇 |
1987年 | 22篇 |
1986年 | 23篇 |
1985年 | 24篇 |
1984年 | 11篇 |
1983年 | 16篇 |
1982年 | 9篇 |
1979年 | 9篇 |
1973年 | 11篇 |
1972年 | 8篇 |
1971年 | 8篇 |
1970年 | 5篇 |
1969年 | 8篇 |
1968年 | 5篇 |
1966年 | 5篇 |
排序方式: 共有2735条查询结果,搜索用时 15 毫秒
1.
Zaida Araujo Sietze Brandes Elena Pinelli María A. Bochichio Andrea Palacios Albina Wide Bruno Rivas-Santiago Juan Carlos Jiménez 《Revista do Instituto de Medicina Tropical de S?o Paulo》2015,57(1):47-55
The present study aimed at measuring seropositivities for infection by
Ascaris suum and Toxocara canis using the
excretory/secretory (E/S) antigens from Ascaris suum (AES) and
Toxocara canis (TES) within an indigenous population. In
addition, quantification of cytokine expressions in peripheral blood cells was
determined. A total of 50 Warao indigenous were included; of which 43 were adults and
seven children. In adults, 44.1% were seropositive for both parasites; whereas
children had only seropositivity to one or the other helminth. For ascariosis, the
percentage of AES seropositivity in adults and children was high; 23.3% and 57.1%,
respectively. While that for toxocariosis, the percentage of TES seropositivity in
adults and children was low; 9.3% and 14.3%, respectively. The percentage of
seronegativity was comparable for AES and TES antigens in adults (27.9%) and children
(28.6%). When positive sera were analyzed by Western blotting technique using AES
antigens; three bands of 97.2, 193.6 and 200.2 kDas were mostly recognized. When the
TES antigens were used, nine major bands were mostly identified; 47.4, 52.2, 84.9,
98.2, 119.1, 131.3, 175.6, 184.4 and 193.6 kDas. Stool examinations showed that
Blastocystis hominis, Hymenolepis nana and
Entamoeba coli were the most commonly observed intestinal
parasites. Quantification of cytokines IFN-γ, IL-2, IL-6, TGF-β, TNF-α, IL-10 and
IL-4 expressions showed that there was only a significant increased expression of
IL-4 in indigenous with TES seropositivity (p < 0.002).
Ascaris and Toxocara seropositivity was
prevalent among Warao indigenous. 相似文献
2.
3.
Adilson Cunha Ferreira Edward Araujo Júnior Wellington P. Martins João Francisco Jordão Antônio Hélio Oliani Simon E. Meagher 《The journal of maternal-fetal & neonatal medicine》2015,28(14):1706-1710
Objective: To assess the quality of images and video clips of fetal central nervous (CNS) structures obtained by ultrasound and transmitted via tele-ultrasound from Brazil to Australia.Methods: In this cross-sectional study, 15 normal singleton pregnant women between 20 and 26 weeks were selected. Fetal CNS structures were obtained by images and video clips. The exams were transmitted in real-time using a broadband internet and an inexpensive video streaming device. Four blinded examiners evaluated the quality of the exams using the Likert scale. We calculated the mean, standard deviation, mean difference, and p values were obtained from paired t tests.Results: The quality of the original video clips was slightly better than that observed by the transmitted video clips; mean difference considering all observers = 0.23 points. In 47/60 comparisons (78.3%; 95% CI?=?66.4–86.9%) the quality of the video clips were judged to be the same. In 182/240 still images (75.8%; 95% CI?=?70.0–80.8%) the scores of transmitted image were considered the same as the original.Conclusion: We demonstrated that long distance tele-ultrasound transmission of fetal CNS structures using an inexpensive video streaming device provided images of subjective good quality. 相似文献
4.
2006年7月10-14日,朗斯国际在庆祝公司诞辰8周年之际,广邀新老客户于风景如画的千岛湖畔,展开了一场名为“健康朗斯有约,旖旎千岛相聚”的活动。此次活动规模庞大,受邀客户达200多人。 相似文献
5.
如何把流行的、有特色的、国际性的产品和技术引入国内,是许振铎的兴趣所在。因此,他选择一种最有效的方式——教育培训来进行新概念的推广。[编者按] 相似文献
6.
C M Kyaw C R De Araujo M R Lima E G S Gondim M M Brígido L G Giugliano 《Infection, genetics and evolution》2003,3(2):111-117
Diffusely adhering Escherichia coli (E. coli) strains (DAEC) represent a potential cause of diarrhoea in infants, and the detection of type three secretion system (TTSS) genes in DAEC would substantiate their pathogenic nature. In this work, four isolates of DAEC, recovered from stools of diarrhoeic children, were analysed by PCR, in order to detect the presence of TTSS genes. Primers targeted to the escC, escJ, escN and escV, some of the most conserved TTSS genes in enteropathogenic and enterohaemorrhagic Escherichia coli (EPEC and EHEC), were used in order to verify the occurrence of homologous genes in our DAEC isolates. By this approach, we were able to characterise DNA fragments corresponding to putative escJ and escN genes in all DAEC isolates. Furthermore, DNA fragments homologous to the escC and escV genes were also amplified from all isolates. Besides the similarity found among the DAEC esc homologues with EPEC and EHEC esc genes, the nucleotide sequence analysis of the flanking regions of the amplified DNA fragments suggests that the putative DAEC esc genes are organised in the same manner as observed in EPEC and in EHEC strains. The results described here provide strong evidence for the presence of a TTSS in the DAEC strains analysed, implicating a pathogenic nature of these isolates. 相似文献
7.
Isis Gayed M Farahnaz Eskandari Peter McLaughlin Barbara Pro Roxana Diba Bita Esmaeli 《Ophthalmic surgery, lasers & imaging》2007,38(4):319-325
BACKGROUND AND OBJECTIVE: An observational case series to assess the value of positron emission tomography (PET) in staging ocular adnexal lymphomas and evaluating their response to therapy. PATIENTS AND METHODS: The clinical records of 16 consecutive patients with ocular adnexal lymphoma for whom pretreatment and posttreatment PET scans and corresponding computed tomography (CT) and magnetic resonance imaging (MRI) scans were available were compared. RESULTS: Pretreatment PET scans demonstrated fluorine 18-fluorodeoxyglucose (FDG) positive lesions in 15 orbits of 12 patients. In 1 patient with low-grade follicular lymphoma of the orbit, PET revealed an additional focus of lymphoma in the deltoid muscle that was missed on clinical examination and conventional radiography. All of the posttreatment PET scans showed complete resolution of FDG uptake, suggesting good response to therapy. However, posttreatment CT and MRI scans demonstrated residual masses in 3 patients. CONCLUSIONS: PET is valuable for initial staging of ocular adnexal lymphomas and may be a good adjunct to conventional imaging in evaluation of response to therapy. 相似文献
8.
Berman Brian MD PhD Flores Javier MD † Pariser David MD ‡ Pariser Robert MD ‡ Araujo Tami de MD Ramirez Claudia C. MD 《Dermatologic surgery》2005,31(2):135-138
BACKGROUND Dermatologic procedures often cause some degree of pain. A self-warming patch containing lidocaine and tetracaine (L/T) was developed to provide topical local anesthesia prior to painful procedures.
OBJECTIVES To evaluate the safety and efficacy of a self-warming L/T patch to provide anesthesia in adult patients undergoing minor dermatologic procedures.
METHODS An active or placebo study drug was placed on adults 30 minutes prior to minor dermatologic surgical procedures in a prospectively randomized, double-blinded manner. Subcutaneous lidocaine injection was available during the procedure as a rescue medication if requested by the subject. Immediately following the procedure, the subjects, the investigator, and an independent observer rated pain intensity and adverse events were recorded.
RESULTS Patient-reported pain intensity was significantly lower in the L/T patch group ( p < .001 ). Investigators and an independent observer rated the pain in the L/T patch group to be less than in the placebo patch group ( p = .004 and p < .001 , respectively). Forty-nine percent of patients in the placebo group required rescue subcutaneous lidocaine compared with 22% in the L/T patch study group ( p = .008 ). One patient in the L/T patch group reported a transient moderate burning sensation.
CONCLUSION The self-warming L/T patch was effective in providing clinically useful local anesthesia for minor dermatologic procedures in adult patients.
ZARS, INC., PROVIDED SUPPORT VIA A SPONSORED RESEARCH GRANT TO THE UNIVERSITY OF MIAMI. 相似文献
OBJECTIVES To evaluate the safety and efficacy of a self-warming L/T patch to provide anesthesia in adult patients undergoing minor dermatologic procedures.
METHODS An active or placebo study drug was placed on adults 30 minutes prior to minor dermatologic surgical procedures in a prospectively randomized, double-blinded manner. Subcutaneous lidocaine injection was available during the procedure as a rescue medication if requested by the subject. Immediately following the procedure, the subjects, the investigator, and an independent observer rated pain intensity and adverse events were recorded.
RESULTS Patient-reported pain intensity was significantly lower in the L/T patch group ( p < .001 ). Investigators and an independent observer rated the pain in the L/T patch group to be less than in the placebo patch group ( p = .004 and p < .001 , respectively). Forty-nine percent of patients in the placebo group required rescue subcutaneous lidocaine compared with 22% in the L/T patch study group ( p = .008 ). One patient in the L/T patch group reported a transient moderate burning sensation.
CONCLUSION The self-warming L/T patch was effective in providing clinically useful local anesthesia for minor dermatologic procedures in adult patients.
ZARS, INC., PROVIDED SUPPORT VIA A SPONSORED RESEARCH GRANT TO THE UNIVERSITY OF MIAMI. 相似文献
9.
上海美发美容行业协会于2006年6月2日举行新闻媒体通气会,向社会各界表示:正牌染发剂不会致癌。由于央视近期报道了北京某消费者因染发导致皮肤严重过敏的新闻,染发剂是否治癌一时成了社会关注的焦点,并由此引发了媒体对染发剂安全性的质疑。上海协会专家以及各方专业人士经过1个多月的调研,认为染发剂致癌之说是不科学的,优质、正牌的染发剂绝对不会致癌。 相似文献
10.
郑春影提倡“领先半步”。所以5年前。他开创了行业前店后院的新模式,5年后。他要将这种模式升级更新。[编者按] 相似文献