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1.
JM Martín† L Calduch† C Monteagudo‡ I Molina† D Ramón† V Alonso† E Jordᆠ《Journal of the European Academy of Dermatology and Venereology》2006,20(4):428-431
Cutaneous plasmacytosis is a rare disorder characterized by a benign proliferation of mature plasma cells that appears as multiple dark-brown to purplish skin lesions, often associated with polyclonal hypergammaglobulinaemia. We present the case of a 55-year-old Caucasian man who suffered from a cutaneous plasmacytosis associated with two different carcinomas. Cutaneous plasmacytosis seems to be a reactive process because most cases reported are not associated with any apparent underlying disease. Nevertheless, because few reported cases were associated with malignancies, screening of additional neoplasms would be justified. 相似文献
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JM Vilanova J Figueras-Aloy J Roselló G Gómez E Gelpí R Jiménez 《Acta paediatrica (Oslo, Norway : 1992)》1998,87(5):588-592
The aim of this study was to evaluate the cerebral synthesis of eicosanoids in the asphyctic newborn and to investigate the relation between the prostanoid profiles in cerebrospinal fluid (CSF) and the appearance and severity of hypoxic-ischaemic encephalopathy (HIE). Levels of 6-keto-PGF 1-α, TXB2 , PGE2 and PGF2-α in CSF were measured in 40 full term newborns during the first day of life. Thirty of these newborns had birth asphyxia and were divided into three groups: 10 without HIE, 12 with mild HIE and 8 with moderate-severe HIE. They were compared to a control group of 10 non-hypoxic newborns. Determinations of the metabolites in CSF were performed by RIA and expressed as pg/ml (mean ± SD). The CSF TXB2 (thromboxane A2 metabolite) in asphyxiated newborns was always higher than in the control group (28.12 ± 10.6), and related to the severity of HIE ( p = 0:005): without HIE (50.84 ± 16.4; p = 0:02), mild HIE (80.65 ± 12.64; p ± 0:01) and moderate-severe HIE (178.14 ± 20.5; p < 0:01). The CSF 6-keto-PGF 1-α (prostacyclin metabolite) in asphyxiated newborns was always higher than in the control group (80.55 ± 12.56), but indirectly related to the severity of HIE: without HIE (240.95 ± 28.12; p < 0:01), mild HIE (183.65 ± 30.1; p < 0:01) and moderate-severe HIE (140.55 ± 25.12; p < 0:01). In the moderate-severe HIE group, the increase in TXB2 was higher than the rise in 6-keto-PGF 1-α . 相似文献
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Occurrence of the t(2;5)(p23;q35) in non-Hodgkin's lymphoma 总被引:9,自引:3,他引:6
Weisenburger DD; Gordon BG; Vose JM; Bast MA; Chan WC; Greiner TC; Anderson JR; Sanger WG 《Blood》1996,87(9):3860-3868
Primary CD30(Ki-1)-positive anaplastic large-cell lymphoma (ALCL) is considered by some to be a distinct clinicopathologic entity associated with the t(2;5) (p23;q35). However, the specificity of t(2;5) for ALCL has not been carefully studied. Therefore, we performed a detailed analysis of all cases of ALCL with abnormal cytogenetics results in the Nebraska Lymphoma Study Group registry, as well as all other cases of non-Hodgkin's lymphoma with t(2;5) in the registry. We found the t(2;5) in only five of 10 cases of ALCL, four of whom were young patients. However, we also found the t(2;5) in 11 other cases of nonanaplastic lymphoma, including eight children with typical peripheral T-cell lymphomas of various types. The t(2;5) was also found in three older adults with B-cell lymphomas of various types. Thus, the t(2;5) was not specific for CD30+ ALCL. However, t(2;5) may define a clinicopathologic entity in children and young adults characterized by variable morphologies with a T-cell or indeterminate phenotype, CD30-positivity, nodal disease with frequent extranodal involvement, advanced stage, and an excellent response to therapy, including bone marrow transplantation for relapsed disease. The clinical relevance of the t(2;5) in older patients requires further study. 相似文献
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Environmental and genetic determinants of the hypercoagulable state and cardiovascular disease in renal transplant recipients 总被引:4,自引:1,他引:3
Background. Fibrinogen and factor VII coagulant
activity (VIIc), risk factors for cardiovascular disease (CVD) in the
general population, could contribute to CVD risk in renal transplant
recipients (RTR). Methods. We measured fibrinogen and
VIIc in 38 RTR and 31 controls, along with prothrombin fragment F1+2 and
D-Dimer (markers of coagulation and fibrinolytic activation), plasma lipids
and the acute phase response cytokine, interleukin 6. The effect of genetic
polymorphisms of {beta}-fibrinogen (G/A-455) and
factor VII (Arg/Gln353) was explored. Results. F1+2,
D-Dimer, and fibrinogen were increased in all RTR, indicating a chronic
prothrombotic state. Fibrinogen correlated with age, F1+2, and trough
cyclosporin A (CsA). RTR carriers of the A-455
allele had a greater increment in plasma fibrinogen concentration and
correlation with CsA than homozygotes for the G-455
allele. Interleukin 6 was increased in RTR confirming that a persistent
low-grade acute-phase response could contribute to increased fibrinogen.
Differences in plasma VIIc were associated with factor VII genotype,
disease status, and blood lipids. Carriers of the Gln353 allele had 30
lower VIIc when compared with Arg353 homozygotes, which could confer a
reduced thrombotic risk. The 12 RTR with CVD or metabolic complications
(RTR+) were more hyperlipidaemic and had higher fibrinogen and VIIc than
the 26 RTR free of disease complications (RTR-), or the controls.
Conclusions. Long-term RTR manifest features of a
chronic prothrombotic and persistent inflammatory state. Alterations in
fibrinogen and VIIc in RTR arise in part as a result of interactions
between common genetic and environmental factors, and these changes could
contribute to the increased risk of CVD in RTR. 相似文献