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Chukwuemeka R. Nwokocha Magdalene I. Nwokocha Imaria Aneto Joshua Obi Damian C. Udekweleze Bukola Olatunde Daniel U. Owu Moses O. Iwuala 《Food and chemical toxicology》2012
Scope
L. esculentum (tomato) contain compounds with anti-oxidant and anti-inflammatory properties, able to synthesize metal chelating proteins. We examined the ability of fruit extract to protect against mercury (Hg), lead (Pb) and cadmium (Cd) accumulation in the liver.Methods and results
Rats were fed on tomato mixed with rat chow (10% w/w), while Hg (10 ppm), Cd (200 ppm) and Pb (100 ppm) was given in drinking water. Tomato was administered together with the metals (group 2), a week after exposure (group 3) or a week before metal exposure (group 4) for a period of six weeks. The metal accumulations in the liver were determined using AAS. There was a significant (P < 0.05) increase in protection by tomato to Cd and Hg accumulation but not to Pb (P < 0.05) in weeks 2 and 4 for groups 2 and 3. The protective ability was significantly (P < 0.05) increased for Pb in group 4, but was less comparable to Cd and Hg.Conclusion
Tomato reduces uptake while enhancing the elimination of these metals in a time dependent manner. The highest hepatoprotective effect was to Cd followed by Hg and least to Pb. Its administration is beneficial in reducing heavy metal accumulation in the liver. 相似文献5.
Ningqi Hou Temidayo Ogundiran Oladosu Ojengbede Imran Morhason-Bello Yonglan Zheng James Fackenthal Clement Adebamowo Imaria Anetor Stella Akinleye Olufunmilayo I. Olopade Dezheng Huo 《Annals of epidemiology》2013,23(9):551-557
PurposeLittle is known about risk factors for pregnancy-associated breast cancer (PABC), diagnosed during pregnancy or postpartum.MethodsWe enrolled 1715 premenopausal women from the Nigerian Breast Cancer Study from 1998 to 2011. Based on recency of last pregnancy from diagnosis, breast cancer cases were categorized as (1) PABC diagnosed 2 years or longer postpartum, (2) PABC diagnosed 3 to 5 years postpartum, or (3) non-PABC diagnosed more than 5 years postpartum. Controls were matched to cases on recency of last pregnancy. Multiple logistic regressions were performed comparing cases and controls within each group.ResultsOf the 718 cases, 152 (21.2%) had PABC 2 or more years postpartum, and 145 (20.2%) 3 to 5 years postpartum. Although not statistically significant, women with higher parity tend to have an elevated risk of PABC but reduced risk of non-PABC (p for heterogeneity = 0.097). Family history of breast cancer might be a strong predictor particularly for PABC 2 or more years postpartum (odds ratio, 3.28; 95% confidence interval, 1.05–10.3). Compared with non-PABC cases, PABC 2 or more years postpartum cases were more likely to carry BRCA1/2 mutations (P = .03).ConclusionsParity may have different roles in the development of PABC versus other premenopausal breast cancer in Nigerian women. Prospective mothers with multiple births and a family history of breast cancer may have an elevated risk of breast cancer during their immediate postpartum period. 相似文献
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Breast cancer risk after full‐term pregnancies among African women from Nigeria,Cameroon, and Uganda 下载免费PDF全文
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