A comparative study of the pharmacokinetics and pharmacodynamics of bonnecor]

The pharmacokinetics and pharmacodynamics of bonnecor were studied simultaneously in animals with experimental arrhythmia. It was shown that irrespective of the animal species and individual features of the drug elimination kinetics the level of bonnecor concentration correlated with the antiarrhythmic effect. The data on the excretion of bonnecor and its metabolites in the urine in the dog and man were obtained. The decrease of bioavailability at oral administration of bonnecor was demonstrated to be related to its intensive conversion in metabolite M-I.     

Biomarkers of liver fibrosis: prospective comparison of multimodal magnetic resonance,serum algorithms and transient elastography

Abstract

Background and aims

Accurate biomarkers for quantifying liver fibrosis are important for clinical practice and trial end-points. We compared the diagnostic performance of magnetic resonance imaging (MRI), including gadoxetate-enhanced MRI and ³¹P-MR spectroscopy, with fibrosis stage and serum fibrosis algorithms in a clinical setting. Also, in a subset of patients, MR- and transient elastography (MRE and TE) was evaluated when available.     

Study of Hematological Parameters and Morphometric Indices of Erythrocytes in Rats Exposed to Calcium Oxide Nanoparticles

Bulletin of Experimental Biology and Medicine - In female Wistar rats, we studied the effects of daily 20-day administration of intragastric suspension of nanosized calcium oxide on hematological...     

Heredity and diseases of the organs of the urinary system: results and prospects of research

The paper deals with current ideas of the role played by heredity in the development of diseases of the urinary system organs (USO). Hereditary nephropathies are divided into groups of disorders associated with chromosome aberrations (0.28 percent), monogen-inherited pathology (13 percent), multifactorial or polygen-inherited pathology (86.72 percent). Hereditary predisposition associated with antigenic determinants of the HIA system, immune, metabolic, histological defects and other factors are implicated in the development of multifactorial diseases. The pathways by which the disease predisposition is realized are nonuniform. There prospect well novel biotechnological approaches, virologic, pharmacogenetic studies aimed at understanding of the role of heredity in the development of USO disorders, at diagnosing borderline illnesses, and at preventing the disease manifestations.     

Overexpression of P-glycoprotein is associated with a decreased mitochondrial transmembrane potential in doxorubicin-selected K562 human leukemia cells

We tested the hypothesis of whether overexpression of P-glycoprotein (Pgp) could be coupled with changes in specific mechanisms of antioxidant defense (in particular, transition of mitochondrial transmembrane potential, MTP) in tumor cells chronically exposed to anticancer drugs known to exert their cytotoxicity via oxidative stress. We show elevation of Pgp associated with decreased MTP in doxorubicin-selected K562Dox subline as compared with parental K562 cells. The low MTP was not due to a fewer number of mitochondria in K562Dox cells, nor was it associated with altered content of Bcl-XL protein. We discuss a model for coordinated up-regulation of Pgp and MTP transition in cells that survived chemotherapy-induced oxidative stress.