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Khrystyna Malysheva Konrad Kwaniak Iaroslav Gnilitskyi Adriana Barylyak Viktor Zinchenko Amir Fahmi Olexandr Korchynskyi Yaroslav Bobitski 《Materials》2021,14(6)
A capability for effective tissue reparation is a living requirement for all multicellular organisms. Bone exits as a precisely orchestrated balance of bioactivities of bone forming osteoblasts and bone resorbing osteoclasts. The main feature of osteoblasts is their capability to produce massive extracellular matrix enriched with calcium phosphate minerals. Hydroxyapatite and its composites represent the most common form of bone mineral providing mechanical strength and significant osteoinductive properties. Herein, hydroxyapatite and fluorapatite functionalized composite scaffolds based on electrospun polycaprolactone have been successfully fabricated. Physicochemical properties, biocompatibility and osteoinductivity of generated matrices have been validated. Both the hydroxyapatite and fluorapatite containing polycaprolactone composite scaffolds demonstrated good biocompatibility towards mesenchymal stem cells. Moreover, the presence of both hydroxyapatite and fluorapatite nanoparticles increased scaffolds’ wettability. Furthermore, incorporation of fluorapatite nanoparticles enhanced the ability of the composite scaffolds to interact and support the mesenchymal stem cells attachment to their surfaces as compared to hydroxyapatite enriched composite scaffolds. The study of osteoinductive properties showed the capacity of fluorapatite and hydroxyapatite containing composite scaffolds to potentiate the stimulation of early stages of mesenchymal stem cells’ osteoblast differentiation. Therefore, polycaprolactone based composite scaffolds functionalized with fluorapatite nanoparticles generates a promising platform for future bone tissue engineering applications. 相似文献
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Joanna Kisaa Iaroslav Gnilitskyi Bogumi Cieniek Piotr Krzemiski Micha Marchewka Adriana Barylyak Yaroslav Bobitski 《Materials》2021,14(19)
(1) Background: The shrinkage of water resources, as well as the deterioration of its quality as a result of industrial human activities, requires a comprehensive approach relative to its protection. Advanced oxidation processes show high potential for the degradation of organic pollutants in water and wastewater. TiO2 is the most popular photocatalyst because of its oxidizing ability, chemical stability and low cost. The major drawback of using it in powdered form is the difficulty of separation from the reaction mixture. The solution to this problem may be immobilization on a support (glass beads, molecular sieves, etc.). In order to avoid these difficulties, the authors propose to prepare a catalyst as a titanium plate covered with an oxide layer obtained with laser treatment. (2) Methods: In the present work, we generated titanium oxide structures using a cheap and fast method based on femtosecond laser pulses. The structurized plates were tested in the reaction of methylene blue (MB) degradation under UVA irradiation (365 nm). The photocatalytic activity and kinetic properties for the degradation of MB are provided. (3) Results: Studies of X-ray diffraction (XRD) and scanning electron microscopy (SEM) confirm a titanium oxide layer with laser-induced generated structures that are called “spikes” and “herringbones”. The structurized plates were effective photocatalysts, and their activity depends on the structure of the oxide layer (spike and herringbone). (4) Conclusions: The immobilization of the catalyst on a solid support can be performed in a fast and reproducible manner by using the technique of laser ablation. The layers obtained with this method have been shown to have catalytic properties. 相似文献
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Inhibitory transmission controls the action potential firing rate and pattern of Purkinje cell activity in the cerebellum.
A long-term change in inhibitory transmission is likely to have a profound effect on the activity of cerebellar neuronal circuits.
However, little is known about how neuronal activity regulates synaptic transmission in GABAergic inhibitory interneurons
(stellate/basket cells) in the cerebellar cortex. We have examined how glutamate released from parallel fibers (the axons
of granule cells) influences postsynaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors in stellate
cells and modulates γ-aminobutyric acid (GABA) release from these neurons. First, we found that burst stimulation of presynaptic
parallel fibers changes the subunit composition of post-synaptic AMPA receptors from GluR2-lacking to GluR2-containing receptors.
This switch reduces the Ca2+ permeability of AMPA receptors and the excitatory postsynaptic potential amplitude and prolongs the duration of the synaptic
current, producing a qualitative change in synaptic transmission. This switch in AMPA receptor phenotype can be induced by
activation of extrasynaptic N-methyl-d-aspartate (NMDA) receptors and involves PICK1 and the activation of protein kinase C. Second, activation of presynaptic NMDA
receptors triggers a lasting increase in GABA release from stellate cells. These changes may provide a cellular mechanism
underlying associative learning involving the cerebellum. 相似文献
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Shapiro Ilona Belsky Daniel W. Israel Salomon Youssim Iaroslav Friedlander Yechiel Hochner Hagit 《Age (Dordrecht, Netherlands)》2023,45(2):901-913
GeroScience - Measures of biological age (BA) integrate information across organ systems to quantify “biological aging,” i.e., inter-individual differences in aging-related health... 相似文献
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