全文获取类型
收费全文 | 8419篇 |
免费 | 792篇 |
国内免费 | 86篇 |
专业分类
耳鼻咽喉 | 186篇 |
儿科学 | 157篇 |
妇产科学 | 141篇 |
基础医学 | 1398篇 |
口腔科学 | 112篇 |
临床医学 | 758篇 |
内科学 | 1523篇 |
皮肤病学 | 341篇 |
神经病学 | 700篇 |
特种医学 | 516篇 |
外科学 | 786篇 |
综合类 | 70篇 |
一般理论 | 1篇 |
预防医学 | 350篇 |
眼科学 | 134篇 |
药学 | 997篇 |
中国医学 | 169篇 |
肿瘤学 | 958篇 |
出版年
2023年 | 52篇 |
2022年 | 258篇 |
2021年 | 359篇 |
2020年 | 222篇 |
2019年 | 332篇 |
2018年 | 328篇 |
2017年 | 298篇 |
2016年 | 408篇 |
2015年 | 482篇 |
2014年 | 566篇 |
2013年 | 617篇 |
2012年 | 788篇 |
2011年 | 736篇 |
2010年 | 466篇 |
2009年 | 348篇 |
2008年 | 444篇 |
2007年 | 433篇 |
2006年 | 357篇 |
2005年 | 342篇 |
2004年 | 263篇 |
2003年 | 238篇 |
2002年 | 220篇 |
2001年 | 85篇 |
2000年 | 90篇 |
1999年 | 81篇 |
1998年 | 37篇 |
1997年 | 29篇 |
1996年 | 39篇 |
1995年 | 20篇 |
1994年 | 17篇 |
1993年 | 17篇 |
1992年 | 32篇 |
1991年 | 32篇 |
1990年 | 34篇 |
1989年 | 28篇 |
1988年 | 19篇 |
1987年 | 20篇 |
1986年 | 14篇 |
1985年 | 13篇 |
1984年 | 13篇 |
1983年 | 14篇 |
1982年 | 13篇 |
1981年 | 10篇 |
1980年 | 6篇 |
1979年 | 6篇 |
1978年 | 7篇 |
1976年 | 11篇 |
1975年 | 6篇 |
1974年 | 6篇 |
1973年 | 6篇 |
排序方式: 共有9297条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
5.
Post-transplantation diabetes is better controlled after conversion from prednisone to deflazacort: a prospective trial in renal transplants 总被引:2,自引:0,他引:2
Yu Seun Kim Myoung Soo Kim Soon Il Kim Seung Kil Lim Ho Yung Lee Dae Suk Han Kiil Park 《Transplant international》1997,10(3):197-201
It is well known that long-term use of steroids plays a decisive role in the development of glucose intolerance and diabetes
mellitus (DM). Deflazacort, an oxazoline derivative of prednisolone, has been introduced as a potential substitute for conventional
steroids in order to ameliorate glucose intolerance. We initiated a randomized study of conversion from prednisone to deflazacort
in kidney transplantation (Tx) recipients presenting with pre-Tx or post-Tx DM to ascertain whether or not the switch to deflazacort
would ameliorate the diabetic state. Forty-two recipients in the conversion group were compared with 40 patients on prednisone
(the control group) in a prospective manner. The dose reduction of insulin or oral blood glucose-lowering agents, the adequacy
of glucose control, and the development of side effects were the criteria for evaluating outcome. In the conversion group,
patients were switched to deflazacort at a dose ratio of 6 mg deflazacort to 5 mg prednisone. During the mean follow-up period
of 13.2 months, neither graft dysfunction nor acute rejection developed in the conversion group. Improvement in blood glucose
control in the conversion group was noted. When the conversion group was stratified into pre- or post-Tx DM, promising effects
were clearly evident in the post-Tx DM patients. More than 50 % dose reduction of blood glucose-lowering agents was possible
in 42.3 % of post-Tx DM patients. In conclusion, it was readily possible to control blood glucose better in post-Tx DM recipients
without seriously affecting the immunosuppressive activity after conversion to deflazacort.
Received: 20 August 1996 Received after revision: 25 November 1996 Accepted: 6 December 1996 相似文献
6.
During the past 3 years six episodes of ischemic monomelic neuropathy (IMN) have been identified in five patients as a complication of upper extremity dialysis grafts. All patients had long-standing insulin-dependent diabetes, peripheral neuropathy, and brachial artery graft origins, whereas 60% had peripheral vascular disease. Five episodes occurred immediately after graft placement, whereas one was due to a graft-related thromboembolus. Diagnostic delay was common with initial findings attributed to anesthesia, positioning, or surgical trauma. Electrophysiologic studies showed underlying diabetic neuropathy with severe multifocal neuropathy distal to the grafts. Digital pressure indices were reduced but there was no critical ischemia. In three cases ischemia was completely corrected with improvement in one. One patient had proximal balloon angioplasty with no improvement and of the two untreated patients, one improved slightly. Ischemic monomelic neuropathy is a rare but disabling complication of dialysis access in diabetic uremic patients. Its occurrence is unpredictable and diagnostic delay is common. Correction of ischemia is indicated but usually does not improve the neuropathy. Prevention requires further research to more accurately characterize the patients at risk.Presented at the Twelfth Annual Meeting of the Southern California Vascular Surgical Society, Coronado, Calif., September 17–19, 1993. 相似文献
7.
Susan Yung Heinz Hausser Gareth Thomas Liliana Schaefer Hans Kresse Malcolm Davies 《Peritoneal dialysis international》2004,24(2):147-155
OBJECTIVE: Previous studies have shown that decorin and biglycan account for over 70% of the proteoglycans (PGs) synthesized by human peritoneal mesothelial cells (HPMCs). Since these PGs are involved in the control of cell growth, cell differentiation, and matrix assembly, we investigated their turnover in cultured HPMCs. METHODS: Confluent HPMCs were metabolically labeled with [35S]-sulfate and the labeled products isolated from the cell medium and the cell layer characterized by sensitivity to bacterial eliminases. Experiments were undertaken with exogenous labeled decorin, and its metabolic state was studied. RESULTS: In a 24-hour labeling period, 75% of the newly synthesized chondroitin sulfate/dermatan sulfate (CS/DS) PGs appeared in the culture medium, the majority of which (90%) was decorin. In the cell layer, protein-free glycosaminoglycan (GAG) chains accounted for 21% of the total CS/DS at 24 hours and exhibited constant specific activity at 12-16 hours. The latter material was turned over with a half-life of approximately 2.5 hours. Exogenous decorin underwent receptor-mediated endocytosis and subsequent intracellular degradation. Uptake but not degradation could be inhibited by heparin. CONCLUSIONS: HPMCs are distinguished by a rapid turnover of decorin. A characteristic metabolic feature is the existence of a large intracellular pool of protein-free DS-GAGs. Understanding the control of decorin turnover in HPMCs might lead to delineation of its potential role in both the physiology and pathophysiology of the membrane in PD patients. 相似文献
8.
A male, full-term baby with thrombocytopenia was born by a G3P2A1 mother who was not associated with autoimmune disease. Platelet antibody screening was positive by using lymphocytotoxicity test, platelet suspension immunofluorescence test and solid-phase red cell adherence test. The identified HLA antibody was of A2 specificity. It was confirmed by testing the mother's and the baby's sera against the lymphocytes and platelets of 10 HLA-A2-positive donors. The possibility of platelet-specific antibody as the cause of neonatal alloimmune thrombocytopenia was ruled out by testing against platelets of 10 HLA-A2-negative donors and the known platelet-specific antigens utilizing immobilized, purified platelet glycoprotein as targets. The mother's serum reacted strongly with both the father's and the baby's platelets and lymphocytes. This neonatal thrombocytopenia was most likely due to the maternal HLA antibody, which was induced by her antecedent gestations. 相似文献
9.
Keuk Shun Shin M.D. Seum Chung M.D. Hye Kyung Lee M.D. Jae Duk Lew M.D. 《Aesthetic plastic surgery》1996,20(1):69-76
Reduction mammaplasty was performed in 30 patients by combining the central pedicle flap method with the short submammary scar (3-S) technique to avoid the common drawbacks of currently popular dermoglandular procedures. Reduction was accomplished by using perforating vascular branches from the pectoralis major muscle and its fascia supplying the nipple and breast parenchyme instead of the subdermal plexus. The central vascular pedicle supplying the nipple-areola complex was preserved. Only the periphery of the breast parenchyme was resected circumferentially, with the exception of the inferolateral portion, so as not to injure the sensory nerve. The remaining breast parenchyme was preserved in an inverted cone shape. The nipple-areola complex was safely transposed with great freedom, and the amount of resection was accurately adjusted for symmetry. No cases of nipple-areola complex sensory change occurred postoperatively, and lactation is possible because of preservation of the lactiferous ducts. The length of postoperative scars was reduced by using the short submammary scar technique. We believe this combined method is ideal in patients requiring resections ranging from 200 to 600 g per breast with good skin elasticity and moderate degree of ptosis.Presented at the Sixth Asian Pacific Congress of the International Confederation for Plastic and Reconstructive Surgery, in Seoul, Korea, October 1993. 相似文献
10.