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1.
Sequential Therapy Based on Evolvement of Patterns: A New Model for Treatment of Alzheimer’s Disease
In order to solve the problem of long-term (>9 months) efficacy in the treatment of Alzheimer''s disease (AD) by conventional therapy (CT), a staged and multiply-targeted sequential therapy based on the evolvement of patterns (STEP) was developed. Its main innovations include: (1) the time order of evolution of patterns defined by Chinese medicine (CM) in AD was found, that is, "the orderly pattern evolution starting from Shen (Kidney) deficiency, progressing to phlegm, stasis and fire, and worsening to severe toxin as well as functional collapse"; (2) the cascade hypothesis of Shen deficiency in AD and its sequential therapy based on Shen-reinforcing was proposed, that is, "reinforcing Shen in the early stage and throughout the whole process, resolving phlegm, activating blood and purging fire in the middle stage, detoxifying and replenishing vitality to stop the collapse in the advanced stage", and through meta-analysis, clinical drug use was optimized, thus the leap from "inferential selection" to "evidence-based selection" was realized; (3) the STEP regimen combined with CT maintained cognitive and behavioral stability in AD patients for at least 12 months, with cognitive enhancement and behavioral synergy after 9 months, and cognitive benefit was superior to CT at 9, 12, 15, 18, 21, and 24 months, respectively. The 2-year cognitive improvement rate was increased by 25.64% (P=0.020) and the cognitive deterioration rate was decreased by 48.71% (P=0.000). Among them, the cognitive and functional benefits of Shen-reinforcing therapy for very early AD (350 cases) for 1 year were better than the placebo (P<0.001), and the dementia conversion rate was reduced by 8.85% (P=0.002). The behavioral symptomatic relief of patients with vascular dementia received fire-purging therapy (540 cases) was superior to those received CT (P=0.016). These data suggested that the STEP regimen has synergistic effects on CTs at least in terms of cognitive benefit, and the earlier the use, the greater the benefit will have. Therefore, the STEP regimen should be considered as one of the clinical options, particularly for the dearth of effective pharmaceutical or immunological interventions that are currently available for AD. 相似文献
2.
试析陆懋修从阳明论治温病之特色 总被引:1,自引:0,他引:1
陆懋修(1818-1886),又名免研,字九芝,号江左下工,又号林屋山人,江苏元和(今江苏吴县)人,为清代后期著名的医学家。陆氏出身于官宦之家,儒医兼通,陆氏秉承家学,对先人的医学成就颇为敬重。他曾三十余年坚持潜心研究《内经》、《伤寒》等医学经典著作,终于贯通医理而成为一代名医。陆氏一生博览群书之余,著述不断, 相似文献
3.
用有机锗(Ge-132)试验治疗荷移植肝癌小鼠。结果:De-132高剂量(12.5mg/次)治疗组的抑癌率为用31.0%,移植肝癌白细胞(WBC)浸润(+++)占72.7%、血清超氧化物歧化酶(SOD)活性为121Nu/ml,而生理盐水对照治疗组相应的后两项指标分别为用36.4%及81Nu/ml,两组比较有显著性差异(P<0.05);环磷酰胺(CTX)治疗组的抑癌率为37.0%,癌体WBC浸润(+++)为27.3%,血清SOD活性为102Nu/ml;ge-132高剂量与CTX2联合治疗组的抑癌率为45.0%,癌体WBC浸润(+++)为54.5%,血清SOD活性为142Nu/ml,两组比较,后二项指标有显著性差异(P<0.05)。由此提示Ge-132高剂量能明显增强荷移植肝癌小鼠的细胞免疫及血清SOD活性,并有一定的抗移植肝癌作用。 相似文献
4.
解磷注射液救治急性有机磷农药中毒34例临床报告 总被引:1,自引:0,他引:1
将急性有机磷农药中毒患者69例随机分为2组,一组主要应用解磷注射液治疗(新疗法34例),另一组(35例)主要应用阿托品治疗。两组治愈率分别为97.1%及77.1%,疗效比较差异显著(P<0.05)。新疗法的优点是起效快,作用持久,疗程短(两组比较P<0.001),副反应轻,值得推广应用。并就应用方法及注意事项等作了探讨,也强调了早期足量用药的重要性。 相似文献
5.
采用钕钆铝石榴石激光切除白内障囊外摘除术后101例后房人工晶体植入后252例的后囊混浊共353例,激光治疗疗后视力均明显提高,矫正视力>1.0者占82.4%,无1例<0.5。无明显并发症。 相似文献
6.
7.
重睑成形术是眼睑美容手术之一。随着人民生活水平的提高,要求美容的人也越来越多[1]。由于该手术大部分需要切开剥离,去除眼轮匝肌或去脂去皮,容易引起皮下组织水肿、淤血,影响恢复和术后效果。2005年11月—2006年11月,笔者对124例重睑受术者进行术中冰生理盐水冷敷,在减轻水肿、淤血程度、缩短恢复期方面疗效显著。现报道如下。1资料与方法1.1临床资料本组共124例,其中女118例,男6例,年龄20岁~58岁。将受术者按手术时间先后顺序随机分为实验组和对照组各62例。1.2方法两组均使用电凝止血,5-0丝线缝合后用无菌纱布包扎伤口,口服5d抗生素。… 相似文献
8.
A tumor-targeted and conditionally replicating oncolytic adenovirus vector expressing TRAIL for treatment of liver metastases. 总被引:3,自引:0,他引:3
Pavel Sova Xiao-Wei Ren Shaoheng Ni Kathrin M Bernt Jie Mi Nancy Kiviat André Lieber 《Molecular therapy》2004,9(4):496-509
We have constructed a new capsid-modified adenovirus (Ad) vector that specifically replicates in tumor cells and expresses TNF-related apoptosis-inducing ligand (TRAIL). The Ad capsid contains short-shafted fibers derived from Ad serotype 35, which allow for efficient infection of malignant tumor cells, and largely avoids innate toxicity after intravenous application. Replication-dependent homologous recombination in Ad genomes was used to achieve tumor-specific expression of Ad E1a (to mediate viral replication) and TRAIL (to mediate apoptosis and enhance release of progeny virus from infected cells). We demonstrated that our oncolytic vector (Ad5/35.IR-E1A/TRAIL) induced apoptosis in human tumor cell lines derived from colorectal, lung, prostate, and liver cancer. Both in vitro and in vivo tumor models showed efficient intratumoral spread of this vector. In a model for metastatic colon cancer, tail vein infusion of Ad5/35.IR-E1A/TRAIL resulted in elimination of preestablished liver metastases. Intravenous injection of this vector caused a transient elevation of serum glutamic pyruvic transaminase in tumor-bearing mice, which we attributed to factors released from apoptotic tumor cells. Liver histology analyzed at day 14 after virus injection did not show signs of hepatocellular damage. This new oncolytic vector represents a potentially efficient means for gene therapy of metastatic cancer. 相似文献
9.
孕妇血清AFP、uE3和β-hCG水平与严重胎儿缺陷的关系 总被引:3,自引:0,他引:3
①目的 探讨孕中期血清甲胎球蛋白(AFP),游离雌三醇(uF3)和β绒毛膜促性腺激素(β-HCG)水平与严重胎儿缺陷的关系。②方法 用ELISA方法对832例16-21周妊娠妇女血清AFP、UE3和β-hCG进行检测,以筛查阳性病人。③结果 14例胎儿被确诊为异常,其中唐氏综征2例,无脑儿3例,脊柱裂3例,唇腭裂1例,腹裂肠外翻1例,孕中期自然流产2例,死胎1例,葡萄胎1例,总检出率为1.68%,假阳性15例,占被检人数的1.80%。④结论 以上3种生化指标联合检测可作为产前诊断严重胎儿缺陷的有效方法。 相似文献
10.