全文获取类型
收费全文 | 994篇 |
免费 | 49篇 |
国内免费 | 50篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 34篇 |
妇产科学 | 41篇 |
基础医学 | 70篇 |
口腔科学 | 41篇 |
临床医学 | 120篇 |
内科学 | 171篇 |
皮肤病学 | 26篇 |
神经病学 | 66篇 |
特种医学 | 178篇 |
外科学 | 125篇 |
综合类 | 24篇 |
一般理论 | 1篇 |
预防医学 | 77篇 |
药学 | 76篇 |
中国医学 | 2篇 |
肿瘤学 | 36篇 |
出版年
2021年 | 10篇 |
2019年 | 9篇 |
2018年 | 12篇 |
2017年 | 11篇 |
2016年 | 8篇 |
2015年 | 41篇 |
2014年 | 40篇 |
2013年 | 76篇 |
2012年 | 36篇 |
2011年 | 34篇 |
2010年 | 28篇 |
2009年 | 30篇 |
2008年 | 27篇 |
2007年 | 54篇 |
2006年 | 25篇 |
2005年 | 30篇 |
2004年 | 32篇 |
2003年 | 20篇 |
2002年 | 27篇 |
2001年 | 18篇 |
2000年 | 20篇 |
1999年 | 26篇 |
1998年 | 26篇 |
1997年 | 31篇 |
1996年 | 17篇 |
1995年 | 23篇 |
1994年 | 19篇 |
1993年 | 14篇 |
1992年 | 22篇 |
1991年 | 21篇 |
1990年 | 23篇 |
1989年 | 24篇 |
1988年 | 24篇 |
1987年 | 20篇 |
1986年 | 11篇 |
1985年 | 14篇 |
1984年 | 19篇 |
1983年 | 15篇 |
1982年 | 12篇 |
1981年 | 6篇 |
1980年 | 8篇 |
1976年 | 18篇 |
1973年 | 4篇 |
1971年 | 4篇 |
1970年 | 4篇 |
1969年 | 5篇 |
1968年 | 8篇 |
1967年 | 4篇 |
1949年 | 4篇 |
1947年 | 6篇 |
排序方式: 共有1093条查询结果,搜索用时 10 毫秒
1.
氟喹诺酮类药物不良反应168例分析 总被引:12,自引:0,他引:12
0 引言 随着氟喹诺酮类药物在临床的广泛应用,有关其应用所致不良反应的报道也日趋增多,我们通过对1990/2003年我院氟喹诺酮类药物不良反应情况报告如下,供临床参考。 相似文献
2.
R. J. Bosma A. J. Kwakernaak J. J. Homan van der Heide P. E. de Jong G. J. Navis 《American journal of transplantation》2007,7(3):645-652
Obesity is a risk factor for renal graft loss. Higher body mass index (BMI) in native kidneys is associated with glomerular hyperfiltration. Whether higher BMI in renal transplants is associated with hyperfiltration is unknown. We investigated the impact of BMI on renal hemodynamics 1 year post-transplant. We analyzed glomerular filtration rate (GFR, (125)I-iothalamate) and effective renal plasma flow (ERPF, (131)I-hippurate) in 838 kidney transplants. Data were analyzed for all patients and for the subpopulation without diabetes. Long-term impact of BMI and renal hemodynamics were explored by Cox-regression. With higher BMI GFR and filtration fraction (FF) increased significantly. Multivariate analysis supported impact of BMI on GFR (adjusted r(2) of the model 0.275) and FF (adjusted r(2) of the model 0.158). This association was not explained by diabetes mellitus. On Cox-regression analysis, lower GFR and higher FF were independent determinants of overall graft loss and graft loss by patient mortality. Lower GFR and higher BMI were determinants of death-censored graft loss, with borderline contribution of higher FF. In renal transplants higher BMI is independently associated with higher GFR and FF one year posttransplant, suggesting glomerular hyperfiltration with altered afferent-efferent balance. Mechanisms underlying the long-term prognostic impact of hyperfiltration deserve further exploration. 相似文献
3.
Guoping Lian Mark E Malone Jenny E Homan Ian T Norton 《Journal of controlled release》2004,98(1):139-155
This paper presents a mathematical model of in-mouth volatile release from gelled emulsion particles dispersed in a continuous aqueous phase. Data based on APCI MS-Breath analysis is presented to demonstrate the effect of particle size, oil content and oil-water partition coefficients. It is shown that in-mouth release of aroma from the dispersion of gelled emulsion particles follows a two-component kinetic equation with fast and slow components. Both the fast and slow rate constants depend on the particle size, oil content and oil water partition coefficient of the aroma. The relative amount of aroma contributing to the fast and slow components also depends on the size of the particles. In order to understand this unexpected behaviour, an analytical model was developed that considers the interplay between the mass transfer of flavour across the interface of the particles and that across the air-liquid interface. Analytical expressions for the two rate constants and the relative ratio of aroma contributing to the fast component have been derived. From this model, three regimes of in-mouth release of aroma from the dispersion of gelled emulsion particles were identified including, the emulsion regime, the transition regime and the gel particle regime. In the emulsion regime, changes in the size of gelled emulsion particles had negligible impact on the overall release. In the transition regime, the release was controlled by the interaction of flavour transfer from the particles with that across the air-water interface. In the gel particle regime, aroma release at long times was governed by the particles and that at short times was governed by the air-water interface, and the two processes were fully decoupled. A simple relationship was derived for the critical size above which the release of aroma from the dispersion of gelled emulsion particles is affected by the size of the particles. 相似文献
4.
Rechtsanwalt Dr. iur. Matthias Dann LL.M. 《MedR Medizinrecht》2007,25(11):638-643
Ohne Zusammenfassung 相似文献
5.
J. KRØLL 《Scandinavian journal of immunology》1983,17(S10):171-173
6.
J. KRØLL 《Scandinavian journal of immunology》1983,17(S10):165-169
7.
J. KRØLL 《Scandinavian journal of immunology》1983,17(S10):135-139
8.
9.
10.
Mahadevaiah SK; Odorisio T; Elliott DJ; Rattigan A; Szot M; Laval SH; Washburn LL; McCarrey JR; Cattanach BM; Lovell-Badge R; Burgoyne PS 《Human molecular genetics》1998,7(4):715-727
An RNA-binding motif (RBM) gene family has been identified on the human Y
chromosome that maps to the same deletion interval as the 'azoospermia
factor' (AZF). We have identified the homologous gene family (Rbm) on the
mouse Y with a view to investigating the proposal that this gene family
plays a role in spermatogenesis. At least 25 and probably >50 copies of
Rbm are present on the mouse Y chromosome short arm located between Sry and
the centromere. As in the human, a role in spermatogenesis is indicated by
a germ cell-specific pattern of expression in the testis, but there are
distinct differences in the pattern of expression between the two species.
Mice carrying the deletion Yd1, that maps to the proximal Y short arm, are
female due to a position effect resulting in non-expression of Sry ;
sex-reversing such mice with an Sry transgene produces males with a high
incidence of abnormal sperm, making this the third deletion interval on the
mouse Y that affects some aspect of spermatogenesis. Most of the copies of
Rbm map to this deletion interval, and the Yd1males have markedly reduced
Rbm expression, suggesting that RBM deficiency may be responsible for, or
contribute to, the abnormal sperm development. In man, deletion of the
functional copies of RBM is associated with meiotic arrest rather than
sperm anomalies; however, the different effects of deletion are consistent
with the differences in expression between the two species.
相似文献