全文获取类型
收费全文 | 5484篇 |
免费 | 280篇 |
国内免费 | 35篇 |
专业分类
耳鼻咽喉 | 55篇 |
儿科学 | 76篇 |
妇产科学 | 79篇 |
基础医学 | 625篇 |
口腔科学 | 130篇 |
临床医学 | 322篇 |
内科学 | 1755篇 |
皮肤病学 | 150篇 |
神经病学 | 393篇 |
特种医学 | 225篇 |
外科学 | 853篇 |
综合类 | 22篇 |
预防医学 | 105篇 |
眼科学 | 65篇 |
药学 | 326篇 |
中国医学 | 28篇 |
肿瘤学 | 590篇 |
出版年
2023年 | 36篇 |
2022年 | 58篇 |
2021年 | 124篇 |
2020年 | 75篇 |
2019年 | 85篇 |
2018年 | 116篇 |
2017年 | 103篇 |
2016年 | 128篇 |
2015年 | 137篇 |
2014年 | 159篇 |
2013年 | 178篇 |
2012年 | 347篇 |
2011年 | 388篇 |
2010年 | 203篇 |
2009年 | 187篇 |
2008年 | 317篇 |
2007年 | 351篇 |
2006年 | 325篇 |
2005年 | 331篇 |
2004年 | 331篇 |
2003年 | 399篇 |
2002年 | 347篇 |
2001年 | 100篇 |
2000年 | 74篇 |
1999年 | 98篇 |
1998年 | 80篇 |
1997年 | 51篇 |
1996年 | 62篇 |
1995年 | 46篇 |
1994年 | 72篇 |
1993年 | 42篇 |
1992年 | 57篇 |
1991年 | 38篇 |
1990年 | 36篇 |
1989年 | 35篇 |
1988年 | 30篇 |
1987年 | 45篇 |
1986年 | 19篇 |
1985年 | 19篇 |
1984年 | 17篇 |
1983年 | 8篇 |
1982年 | 20篇 |
1981年 | 14篇 |
1980年 | 15篇 |
1979年 | 11篇 |
1978年 | 8篇 |
1977年 | 13篇 |
1971年 | 6篇 |
1970年 | 6篇 |
1969年 | 7篇 |
排序方式: 共有5799条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
5.
Masahiro Miyashita Junko Otsuki Yosuke Hanai Yoshiaki Nakagawa Hisashi Miyagawa 《Toxicon》2007,50(3):428-437
Scorpion venoms are composed of a number of neurotoxic peptides. A variety of toxins have been isolated from the venoms of scorpions of the family Buthidae, however, little interest has been paid to non-Buthidae scorpions. In this study, we examined the toxicity of the venom of Liocheles australasiae (Hemiscorpiidae) to mice and crickets, and characterized the peptide components by HPLC and mass spectrometry. Over 200 components were detected in the L. australasiae venom by LC/MS analysis, with components of molecular masses ranging from 500 to 5000 Da being particularly abundant. A number of peptides contained two to four disulfide bridges, which was estimated based on the mass difference after derivatization of Cys residues. A peptide having a monoisotopic molecular mass of 7781.6 Da and four disulfide bridges was isolated from the venom. The peptide has a primary structure similar in terms of the position of eight Cys residues to those observed in several peptides found from scorpions, ticks and insects, although biological roles of these peptides are unknown. 相似文献
6.
Mana Ichimura Koichi Hiratsuka Naomi Ogura Tadahiko Utsunomiya Hiroyuki Sakamaki Toshirou Kondoh Yoshimitsu Abiko Shigeo Otake Masafumi Yamamoto 《Journal of oral pathology & medicine》2006,35(3):167-174
BACKGROUND: To understand the immunopathological features of oral lichen planus (OLP), we analyzed the expression of chemokines in the epithelial cell layers. Methods: Epithelia from OLP or healthy gingiva were collected by laser microdissection. The chemokine and chemokine receptor expressions in the epithelia were analyzed by DNA microarray. RESULTS: High levels of MIP-3alpha/LARC/CCL20 and its receptor CCR6 were expressed in the lesional epithelia. Furthermore, DC-CK1/CCL18, ELC/CCL19, SDF-1/CXCL12 and CXCR4 expressions were also increased. Immunohistologial analysis showed that high numbers of Langerhans cells (LCs) were present in the epithelia of OLP. Lesional epithelia also expressed high levels of the ligands specific for CXCR3 (e.g. MIG/CXCL9, IP-10/CXCL10 and I-TAC/CXCL11) and CCR5 (e.g. RANTES/CCL5). CONCLUSIONS: Infiltration of LCs is orchestrated by CCR6. Further, LCs residing in the lesional epithelia may be a mature phenotype. Moreover, infiltration of T cells in OLP could be mediated by signaling pathways through CXCR3 and CCR5. 相似文献
7.
8.
Hisashi Tanii Norio Taniguchi Hisayoshi Niigawa Takayoshi Hosono Yasumitsu Ikura Sakae Sakamoto Takashi Kudo Tsuyoshi Nishimura Masatoshi Takeda 《Brain research》1996,743(1-2)
The neuroleptic malignant syndrome (NMS) is a life-threatening complication of neuroleptic treatment. To elucidate the pathogenesis of NMS, an animal model has been developed. Experimental rabbits treated with haloperidol (1 mg/kg) by intramuscular injection, were studied for the diagnostic symptoms of increased muscle rigidity, elevated body temperature, and high serum creatine phosphokinase (CPK) level. Administration of haloperidol (1 mg/kg) and atropine (0.4 mg/kg), and exposure to high ambient temperature (35°C) induced a significant increase in electromyographic activity with muscle rigidity similar to that observed in patients with NMS. Such rabbits also showed elevated body temperature and serum CPK value. In addition to the similarity of the signs and symptoms, all parameters measured (muscle rigidity, body temperature, and serum CPK level) were normalized by dantrolene treatment. The effectiveness of dantrolene in the experimental animal partially confirms the validity of this animal model for NMS. This experimental animal model for NMS may be useful to elucidate the pathogenesis of NMS. 相似文献
9.
Effects of ageing on the total number of muscle fibers and motoneurons of the tibialis anterior and soleus muscles in the rat 总被引:1,自引:0,他引:1
The age-related changes in the total number of muscle fibers and motoneurons of the tibialis anterior and soleus muscles were studied using 10-, 65-, and 135-week-old rats. The number of fast twitch muscle fibers was decreased at age 65 weeks, while the numbers of slow twitch fibers and of alpha motoneurons were decreased only later, at age 135 weeks. Therefore, the degenerative process of muscle fibers differs with the fiber type. 相似文献
10.
Yasuhiro Sano Shigeharu Yamashiro Asuka Komano Hisashi Maruko Hiroshi Sekiguchi Yasuo Takayama Ryoji Sekioka Kouichiro Tsuge Isaac Ohsawa Mieko Kanamori-Kataoka Yasuo Seto Akiyoshi Satoh 《Forensic Toxicology》2007,25(2):76-79
We previously reported that the Guardian Bio-Threat Alert (BTA) system could detect (detection limit: about 0.1 μg/ml) staphylococcal
enterotoxin B (SEB), botulinum toxins (BTX) A and B, and ricin, with no interference by white-powdered materials or colored
matrices. In this study, the capability of the BTA system was further assessed. With 10 min of preheating at 60°C, all toxins
could be detected, but with preheating at 80°C, BTX A and B and ricin became undetectable. About 20% SEB could be detected
after heating at 80°C, but this detection ability was completely removed after heating at 100°C. The effects of chemicals
usually used for decontamination, such as sodium hypochlorite, hydrogen peroxide, formaldehyde, and sodium nitrite, on the
detectability of SEB, BTX A, or ricin in the BTA system were also tested. The concentrations giving 50% line intensity for
SEB, BTX A, and ricin were 3.1, 11, and 15 μM for sodium hypochlorite and 88, 210, and 60 mM for formaldehyde, respectively.
The addition of hydrogen peroxide or sodium nitrite did not decrease the detectability even when used at high concentrations. 相似文献