全文获取类型
收费全文 | 2342篇 |
免费 | 129篇 |
国内免费 | 24篇 |
专业分类
耳鼻咽喉 | 27篇 |
儿科学 | 68篇 |
妇产科学 | 10篇 |
基础医学 | 221篇 |
口腔科学 | 149篇 |
临床医学 | 137篇 |
内科学 | 726篇 |
皮肤病学 | 23篇 |
神经病学 | 91篇 |
特种医学 | 98篇 |
外科学 | 419篇 |
综合类 | 33篇 |
预防医学 | 82篇 |
眼科学 | 19篇 |
药学 | 158篇 |
中国医学 | 10篇 |
肿瘤学 | 224篇 |
出版年
2023年 | 7篇 |
2022年 | 40篇 |
2021年 | 62篇 |
2020年 | 32篇 |
2019年 | 36篇 |
2018年 | 55篇 |
2017年 | 34篇 |
2016年 | 63篇 |
2015年 | 60篇 |
2014年 | 88篇 |
2013年 | 100篇 |
2012年 | 122篇 |
2011年 | 174篇 |
2010年 | 89篇 |
2009年 | 61篇 |
2008年 | 101篇 |
2007年 | 116篇 |
2006年 | 158篇 |
2005年 | 118篇 |
2004年 | 112篇 |
2003年 | 122篇 |
2002年 | 132篇 |
2001年 | 56篇 |
2000年 | 46篇 |
1999年 | 40篇 |
1998年 | 39篇 |
1997年 | 20篇 |
1996年 | 35篇 |
1995年 | 26篇 |
1994年 | 13篇 |
1993年 | 13篇 |
1992年 | 21篇 |
1991年 | 35篇 |
1990年 | 26篇 |
1989年 | 22篇 |
1988年 | 17篇 |
1987年 | 28篇 |
1986年 | 13篇 |
1985年 | 22篇 |
1984年 | 13篇 |
1983年 | 12篇 |
1981年 | 7篇 |
1979年 | 11篇 |
1978年 | 8篇 |
1977年 | 8篇 |
1976年 | 7篇 |
1973年 | 10篇 |
1972年 | 8篇 |
1969年 | 7篇 |
1968年 | 9篇 |
排序方式: 共有2495条查询结果,搜索用时 15 毫秒
1.
2.
Kenichi Okubo Masashi Kobayashi Hiromasa Morikawa Eiichi Hayatsu 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2006,54(7):268-272
Objective: Induction chemoradiotherapy followed by anatomical resection is a current therapeutic strategy for non-small-cell lung cancer
with mediastinal node involvement. Dense peritracheal fibrosis and sclerosis after chemoradiotherapy cause difficult mediastinal
node dissection. We evaluated a novel technique to make the mediastinal node dissection easier after induction therapy. Methods: At the end of mediastinoscopic node biopsy for staging of lung cancer, cotton-type collagen was inserted anterior and lateral
to the trachea in patients with pathologically confirmed mediastinal node involve-ment (n=45). The induction therapy consisted
of concurrent use of platinum-based chemotherapy and hyperfractionated radiotherapy. After the chemoradiotherapy all patients
underwent a pulmonary resection with complete mediastinal node dissection 7–12 weeks after the collagen insertion. Surgical
findings of the mediastinum and the time for node dissection were compared with those without collagen insertion at mediastinoscopy
after chemoradiotherapy (n=5). Results: All five patients without collagen insertion showed sclerotic and fibrotic change of mediastinal nodes with severe adhesion
to the trachea. In 42 of 45 patients with collagen insertion (93.3%) the collagen remained unabsorbed and separated the mediastinal
nodes from the trachea. Mediastinal node dissection was easily accomplished by removing mediastinal tissues lateral and anterior
to the collagen. The rate of mediastinal node separation was significantly higher with collagen insertion than without (p<
0.0001). The times for node dissection in patients with and without collagen insertion showed no significant difference. Conclusion: Cotton-type collagen insertion at staging mediastinoscopy for lung cancer separates the mediastinal nodes from the trachea
and makes the node dissection easier after induction chemoradiotherapy. 相似文献
3.
4.
Mana Ichimura Koichi Hiratsuka Naomi Ogura Tadahiko Utsunomiya Hiroyuki Sakamaki Toshirou Kondoh Yoshimitsu Abiko Shigeo Otake Masafumi Yamamoto 《Journal of oral pathology & medicine》2006,35(3):167-174
BACKGROUND: To understand the immunopathological features of oral lichen planus (OLP), we analyzed the expression of chemokines in the epithelial cell layers. Methods: Epithelia from OLP or healthy gingiva were collected by laser microdissection. The chemokine and chemokine receptor expressions in the epithelia were analyzed by DNA microarray. RESULTS: High levels of MIP-3alpha/LARC/CCL20 and its receptor CCR6 were expressed in the lesional epithelia. Furthermore, DC-CK1/CCL18, ELC/CCL19, SDF-1/CXCL12 and CXCR4 expressions were also increased. Immunohistologial analysis showed that high numbers of Langerhans cells (LCs) were present in the epithelia of OLP. Lesional epithelia also expressed high levels of the ligands specific for CXCR3 (e.g. MIG/CXCL9, IP-10/CXCL10 and I-TAC/CXCL11) and CCR5 (e.g. RANTES/CCL5). CONCLUSIONS: Infiltration of LCs is orchestrated by CCR6. Further, LCs residing in the lesional epithelia may be a mature phenotype. Moreover, infiltration of T cells in OLP could be mediated by signaling pathways through CXCR3 and CCR5. 相似文献
5.
Abstract: A prospective study was performed to determine whether low-density lipoprotein (LDL) apheresis, when performed only immediately before and after percutaneous transluminal coronary angioplasty (PTCA), is effective in preventing restenosis of coronary artery lesions following PTCA. Thirty-six patients with coronary heart disease (CHD) and hypercholesterolemia were divided into 2 groups. The 9 patients in the LDL group underwent LDL-apheresis 1 day before and 5 days after PTCA while the 27 patients of the control group underwent PTCA but did not undergo LDL-apheresis. Follow-up coronary angiography (CAG) was performed 4 months after PTCA. The rate of restenosis of coronary artery lesions was significantly lower in the LDL group (0%) than in the control group (30%). These findings suggest that LDL-apheresis, when performed before and after PTCA, is effective in preventing restenosis of coronary artery lesions in patients with CHD and hypercholesterolemia. 相似文献
6.
Skip mediastinal nodal metastases in non-small cell lung cancer 总被引:1,自引:0,他引:1
Fumihiro Tanaka Kazumasa Takenaka Hiroki Oyanagi Takuji Fujinaga Yosuke Otake Kazuhiro Yanagihara Harumi Ito Hiromi Wada 《European journal of cardio-thoracic surgery》2004,25(6):744-1120
Objective: To reveal the incidence and clinical significance of mediastinal nodal metastases without N1-station nodal metastases (‘skip-N2 metastases’) in non-small cell lung cancer (NSCLC). Methods: A total of 450 NSCLC patients who underwent tumor resection with a systemic mediastinal nodal dissection were retrospectively reviewed. p53 status and proliferative activity represented as proliferative index (PI) were also examined immunohistochemically. Results: Skip-N2 metastases were documented in 49 (13%) patients of all 450 patients; among 334 patients without N1-nodal involvement, 18% patients had skip-N2 metastases. The postoperative survival of skip-N2 patients was almost same as that for patients with metastases to both N1 and N2 nodes. Skip-N2 metastases were significantly more frequent in male patients and squamous cell carcinoma patients. In addition, the mean PI for tumor with skip-N2 metastases was significantly higher than that for any other pathologic nodal (pN)-status diseases. Combined with histologic type and PI, the incidences of skip-N2 metastases for adenocarcinoma showing lower PI were only 5% (7/137) of all patients and 7% (7/94) of patients without N1-nodal involvement. Conclusions: N1 nodal status is not a useful predictor of N2 nodal status in NSCLC, because skip-N2 metastases were documented in 18% patients showing no N1-nodal involvement. However, N1 node-guided dissection might be performed in patients with adenocarcinoma showing lower PI, because the incidence of skip-N2 metastases was extremely low. 相似文献
7.
8.
9.
Soichi Hotta Hiromasa Kashimura Shinji Hirai Akira Nakahara Hisayuki Fukutomi Toshiaki Osuga Yasuo Uchiyama 《Lasers in surgery and medicine》1995,16(3):262-271
Background and Objective: To further understand the precise process of the tumor cell degeneration after photodynamic therapy (PDT), laser hyperthermic therapy (LH), and combined treatments using an Nd:YAG laser. It is important to examine initial morphological alteration of tumor cells after these treatments. Study Design/Materials and Methods: In this study, nude mice bearing HeLa cell tumors were treated with PDT, LH, and combined treatments of the two. Tumor tissues obtained immediately after these treatments were analyzed using electron microscopy and morphometry. Results: In the combined treatments, which produced more severe effects on tumor cells, morphological features of apoptosis such as cytoplasmic condensation, blebs, and apoptotic bodies appeared in the cells, although the typical alteration in the nuclear chromatin was not seen. Conclusion: Cytoplasmic alterations may proceed more rapidly than nuclear alterations in the cellular degeneration induced by the single or combined treatments of PDT and LH. 相似文献
10.
We describe characteristic findings in a patient with Marchiafava-Bignami disease who was serially imaged with CT and MR. Involvement of the entire corpus callosum was visualized with both types of imaging. Following administration of gadolinium-DTPA, the lesion was clearly enhanced in the subacute stage.
Correspondence to: S. Otake 相似文献