全文获取类型
收费全文 | 15018篇 |
免费 | 759篇 |
国内免费 | 101篇 |
专业分类
耳鼻咽喉 | 84篇 |
儿科学 | 308篇 |
妇产科学 | 275篇 |
基础医学 | 1731篇 |
口腔科学 | 220篇 |
临床医学 | 926篇 |
内科学 | 4276篇 |
皮肤病学 | 226篇 |
神经病学 | 941篇 |
特种医学 | 547篇 |
外科学 | 2818篇 |
综合类 | 50篇 |
预防医学 | 318篇 |
眼科学 | 124篇 |
药学 | 975篇 |
中国医学 | 40篇 |
肿瘤学 | 2019篇 |
出版年
2023年 | 113篇 |
2022年 | 230篇 |
2021年 | 408篇 |
2020年 | 241篇 |
2019年 | 307篇 |
2018年 | 364篇 |
2017年 | 276篇 |
2016年 | 323篇 |
2015年 | 365篇 |
2014年 | 467篇 |
2013年 | 527篇 |
2012年 | 975篇 |
2011年 | 1001篇 |
2010年 | 570篇 |
2009年 | 483篇 |
2008年 | 856篇 |
2007年 | 933篇 |
2006年 | 967篇 |
2005年 | 877篇 |
2004年 | 929篇 |
2003年 | 884篇 |
2002年 | 939篇 |
2001年 | 258篇 |
2000年 | 216篇 |
1999年 | 264篇 |
1998年 | 227篇 |
1997年 | 180篇 |
1996年 | 157篇 |
1995年 | 116篇 |
1994年 | 115篇 |
1993年 | 94篇 |
1992年 | 148篇 |
1991年 | 138篇 |
1990年 | 130篇 |
1989年 | 115篇 |
1988年 | 84篇 |
1987年 | 78篇 |
1986年 | 79篇 |
1985年 | 66篇 |
1984年 | 52篇 |
1983年 | 31篇 |
1982年 | 30篇 |
1981年 | 22篇 |
1980年 | 30篇 |
1979年 | 30篇 |
1978年 | 17篇 |
1977年 | 17篇 |
1968年 | 18篇 |
1967年 | 15篇 |
1966年 | 14篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
Shimon Kurasawa Takahiro Imaizumi Shoichi Maruyama Keitaro Tanaka Yoko Kubo Mako Nagayoshi Hiroaki Ikezaki Sadao Suzuki Teruhide Koyama Chihaya Koriyama Aya Kadota Sakurako Katsuura-Kamano Kiyonori Kuriki Kenji Wakai Keitaro Matsuo 《International journal of cancer. Journal international du cancer》2023,153(4):732-741
The association between kidney function and cancer incidence is inconsistent among previous reports, and data on the Japanese population are lacking. It is unknown whether kidney function modifies the cancer risk of other factors. We aimed to evaluate the association of estimated glomerular filtration rate (eGFR) with cancer incidence and mortality in 55 242 participants (median age, 57 years; 55% women) from the Japan Multi-Institutional Collaborative Cohort Study. We also investigated differences in cancer risk factors between individuals with and without kidney dysfunction. During a median 9.3-year follow-up period, 4278 (7.7%) subjects developed cancer. Moderately low and high eGFRs were associated with higher cancer incidence; compared with eGFR of 60-74 ml/min/1.73 m2, the adjusted hazard ratios (HRs) (95% confidence intervals [CIs]) for eGFRs of ≥90, 75-89, 45-59, 30-44 and 10-29 ml/min/1.73 m2 were 1.18 (1.07-1.29), 1.09 (1.01-1.17), 0.93 (0.83-1.04), 1.36 (1.00-1.84) and 1.12 (0.55-2.26), respectively. High eGFR was associated with higher cancer mortality, while low eGFR was not; the adjusted subdistribution HRs (95% CIs) for eGFRs of ≥90 and 75-89 ml/min/1.73 m2 were 1.58 (1.29-1.94) and 1.27 (1.08-1.50), respectively. Subgroup analyses of participants with eGFRs ≥60 and <60 ml/min/1.73 m2 revealed elevated cancer risks of smoking and family history of cancer in those with eGFR <60 ml/min/1.73 m2, with significant interactions. Our findings suggest that the relationship between eGFR and cancer incidence was U-shaped. Only high eGFR was associated with cancer mortality. Kidney dysfunction enhanced cancer risk from smoking. 相似文献
3.
Toshiro Hara Rony Chanoch-Myers Nathan D. Mathewson Chad Myskiw Lyla Atta Lillian Bussema Stephen W. Eichhorn Alissa C. Greenwald Gabriela S. Kinker Christopher Rodman L. Nicolas Gonzalez Castro Hiroaki Wakimoto Orit Rozenblatt-Rosen Xiaowei Zhuang Jean Fan Tony Hunter Inder M. Verma Kai W. Wucherpfennig Itay Tirosh 《Cancer cell》2021,39(6):779-792.e11
- Download : Download high-res image (228KB)
- Download : Download full-size image
4.
5.
6.
CROSSOVER COMPARISON BETWEEN THE DEPRESSOR EFFECTS OF LOW AND HIGH WORK-RATE EXERCISE IN MILD HYPERTENSION 总被引:2,自引:0,他引:2
Eiichiro Tashiro Shin-ichiro Miura Manabu Koga Manabu Sasaguri Munehito Ideishi Masaharu Ikeda Hiroaki Tanaka Munehiro Shindo Kikuo Arakawa 《Clinical and experimental pharmacology & physiology》1993,20(11):689-696
1. The relationship between work-rate and the antihypertensive effect of exercise in hypertensives, and the mechanism of that effect, were investigated by a crossover clinical trial. 2. Ten mild hypertensives were randomly divided into two groups. One group performed low work-rate exercise (LWE) on a cycle ergometer for 10 weeks (blood lactate threshold; ~50% of maximum oxygen consumption [V?O2max]). After a 10 week interval without exercise training, these subjects were then switched to a high work-rate exercise (HWE) regimen (4 mmol/ L of blood lactate; ~75% of V?O2max) for another 10 weeks. In the other group, the order of exercise training was reversed. Since two patients withdrew from the protocol during HWE periods, statistical analysis was performed on the data from the remaining eight patients. There were no order effects observed in any of the data from the two groups. 3. During both LWE and HWE, resting blood pressure (BP) fell significantly after the initiation of exercise therapy (P<0.05). Furthermore, the overall effects of 10 weeks of LWE and HWE on BP were not significantly different. 4. The work-rate at the lactate threshold, which reflects physical fitness, had increased significantly by 16 W (P<0.01) after the LWE period and by 11 W (P<0.01) after the HWE. 5. During the LWE period, changes in haemodynamic and humoral variables were not significant, except for a reduction in plasma norepinephrine at week 10 (P<0.05). In the HWE period, changes in haemodynamic and humoral variables were not significant. 6. Based on these findings, LWE is recommended for mild hypertensives because of its safety. 相似文献
7.
Shoji Kubo Hiroaki Kinoshita Kazuhiro Hirohashi Takatsugu Yamamoto 《Journal of Hepato-Biliary-Pancreatic Surgery》1995,2(1):85-89
A case of cystadenocarcinoma of the liver is reported. The patient was a 73-year-old woman in whom a tumor was detected in
the lateral segment of the liver during a health examination. Ultrasonograms and computed tomograms showed a multilocular
cystic mass. Magnetic resonance imaging (MRI) showed a multilocular lowintensity mass, including a high-intensity portion
and a portal branch compressed by the tumor. MRI with gadolinium showed an enhanced cyst wall. The cystic part of the tumor
became smaller and the solid part became larger over a 1-month period, indicating that the tumor was malignant. Subsegmentectomy
(S3) was performed and cystadenocarcinoma with cystadenoma was diagnosed by histopathological examination. Identification of
changes in the appearance of a tumor should be helpful for the differential diagnosis of cystadenoma and cystadenocarcinoma. 相似文献
8.
T Uno H Kondo Y Inoue Y Kawahata M Sotomura K Iuchi G Tsukamoto 《Journal of medicinal chemistry》1990,33(10):2929-2932
A series of novel pyridone carboxylic acids having a 4-hydroxypiperazinyl group at the 7-position of norfloxacin and ciprofloxacin were prepared. The in vivo antibacterial efficacies of these compounds were superior to those of corresponding piperazinyl derivatives. From the results of the studies on the pharmacokinetic profile and toxicity, the 4-hydroxypiperazinyl derivatives were confirmed to be pharmacologically superior to corresponding piperazinyl derivatives. Thus, a 4-hydroxypiperazinyl group was revealed to be a beneficial substituent for potential use in future quinolone antibacterials. 相似文献
9.
T Uno M Takamatsu Y Inoue Y Kawahata K Iuchi G Tsukamoto 《Journal of medicinal chemistry》1987,30(12):2163-2169
A series of 6-fluoro- and 6,8-difluoro-7-(azole substituted)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids were prepared. Structure-activity relationship studies indicated that the antibacterial potency was better when the 6,8-substituents were fluorine atoms and the 7-substituent was either 1-imidazolyl, 20, or 4-methyl-1-imidazolyl, 25. From the results of studies on pharmacokinetic profile and toxicity, 20 and 25 were found to possess excellent antibacterial activities and to show high blood levels after oral administration to mice with low toxicity. 相似文献
10.
Tetsuya Nomura Tatsuya Kawasaki Takuji Tanabe Akihiro Azuma Hiroaki Matsubara 《Annals of thoracic and cardiovascular surgery》2007,13(2):118-121
Mediastinal cystic tumors are well-marginated round lesions that comprise 12% to 18% of all mediastinal masses. These lesions include a variety of diseases with overlapping radiologic appearances and variable prognoses. Pathological examinations are almost always required for differential diagnosis. We encountered a case of anterior mediastinal tumor discovered in the process of investigation of Raynaud's phenomenon. Taking into account the tumor location, a pericardial cyst was initially suspected. However, the tumor was surgically resected and histopathological examinations demonstrated thymus-like tissue in the cyst walls. Raynaud's phenomenon greatly improved after surgery. These findings suggested that cystic thymoma originated from ectopic thymic tissue and is accompanied by paraneoplastic syndrome. 相似文献