全文获取类型
收费全文 | 81篇 |
免费 | 3篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 1篇 |
妇产科学 | 2篇 |
基础医学 | 11篇 |
口腔科学 | 5篇 |
临床医学 | 7篇 |
内科学 | 20篇 |
皮肤病学 | 2篇 |
神经病学 | 5篇 |
特种医学 | 2篇 |
外科学 | 18篇 |
综合类 | 1篇 |
预防医学 | 4篇 |
药学 | 4篇 |
肿瘤学 | 2篇 |
出版年
2023年 | 1篇 |
2021年 | 8篇 |
2020年 | 1篇 |
2019年 | 5篇 |
2018年 | 4篇 |
2017年 | 3篇 |
2016年 | 3篇 |
2015年 | 2篇 |
2014年 | 5篇 |
2013年 | 4篇 |
2012年 | 11篇 |
2011年 | 7篇 |
2010年 | 3篇 |
2009年 | 2篇 |
2008年 | 5篇 |
2007年 | 5篇 |
2006年 | 2篇 |
2005年 | 6篇 |
2004年 | 2篇 |
2003年 | 2篇 |
2001年 | 1篇 |
2000年 | 1篇 |
1996年 | 2篇 |
排序方式: 共有85条查询结果,搜索用时 15 毫秒
1.
The aim of this study was to immobilize a Co(ii) salen complex on KCC-1 as a catalyst that can be recovered (Co(ii) salen complex@KCC-1). Field-emission transmission electron microscopy, FT-IR spectroscopy, thermogravimetric analysis, elemental analysis, atomic absorption spectroscopy, and XRD were used to confirm the structure and chemical nature of Co(ii) salen complex@KCC-1. The oxidation efficiency was obtained for an extensive range of sulfides and alcohols using this sustainable catalyst, alongside O2 as an oxygen source and isobutyraldehyde (IBA) as an oxygen acceptor, with superior selectivity and conversion for the relevant oxidation products (sulfoxides and ketones or aldehydes) under moderate conditions. The μ-oxo and peroxo groups on the ligands of the Co complex appeared to be responsible for the superior activity of the catalyst. Essential factors behind the oxidation of alcohol and sulfoxides were investigated, including the catalyst, solvent, and temperature. In this paper, molecular oxygen (O2) was used as a green oxidant. Furthermore, kinetic studies were conducted, revealing a first-order reaction for the oxidation of both benzyl alcohol and sulfide. The reaction progressed at mild temperature, and the catalyst could be easily recovered and reused for numerous consecutive runs under the reaction conditions, without any substantial reduction in the functionality of the catalytic system.The aim of this study was to immobilize a Co(ii) salen complex on KCC-1 as a catalyst that can be recovered (Co(ii) salen complex@KCC-1). 相似文献
2.
Context: Tarragon [Artemisia dracunculus L. (Asteraceae)] is used as a commercial flavoring and in perfumery. In traditional folk medicine, tarragon has been used for treatment of pain and gastrointestinal disturbances.Objective: This study investigated the antinociceptive effect of the essential oil of A. dracunculus (EOAD) in various experimental models.Materials and methods: The median lethal dose (LD50) of EOAD was estimated using the method of Lorke. The antinociceptive effect was assessed using chemical (formalin and acetic acid) and thermal (hot-plate) nociceptive tests in rats and mice. In all experiments, EOAD was administered intraperitoneally at the doses of 10, 30, 100 and 300?mg/kg.Results: In the acute toxicity test, the value of estimated LD50 for EOAD was 1250?mg/kg. EOAD (100 and 300?mg/kg) significantly reduced (p?0.001) the pain response in the first (59.5 and 91.4%) and second (52.5 and 86.3%) phases of the formalin test, respectively. Central involvement in analgesic profile was confirmed by the hot-plate test, in which the EOAD showed a significant analgesic activity by increasing latency time. EOAD (10, 30, 100 and 300?mg/kg) significantly (p?0.001) inhibited (89, 95, 97 and 97%) the nociception produced by acetic acid. Naloxone failed to antagonize the antinociceptive effect of the essential oil in the acetic acid-induced writhing test. It seems that mechanism(s) other than opioid receptors is (are) involved in the analgesic effect of EOAD.Conclusions: This study reported the peripheral and central antinociceptive activity of the EOAD and rationalized the traditional use of the plant in the treatment of different painful conditions. 相似文献
3.
4.
Mohammad Hasan Kalantar Motamedi M.D. Ali Hemmat M.D. † Pooya Kalani M.D. ‡ Mohammad R. Rezaee M.D. Saeed Safarnezhad M.D. ‡ 《Journal of cardiac surgery》2009,24(3):343-345
Abstract A 45-year-old man with a past history of aortic valve insufficiency presented with recently increasing chest discomfort. Coronary angiography revealed significant stenosis at the mid-portion of the left anterior descending artery and origin of the first obtuse marginal branch. The right coronary artery (RCA) was faintly seen to be free from significant stenosis. (Selective RCA angiography had not been possible.) At surgery while dissecting between the ascending aorta and the main pulmonary artery, the RCA ostium was incidentally found to be located approximately 10 cm above the aortic annulus and 5 cm above the sinotubular junction, between the medial curve of the ascending aorta and the main pulmonary artery. After coronary artery bypass grafts, we repaired the aortic valve and the RCA remained intact. 相似文献
5.
Nifedipine suppresses morphine-induced thermal hyperalgesia: evidence for the role of corticosterone 总被引:1,自引:0,他引:1
Esmaeili-Mahani S Fereidoni M Javan M Maghsoudi N Motamedi F Ahmadiani A 《European journal of pharmacology》2007,567(1-2):95-101
It has been shown that systemic administration of morphine induced a hyperalgesic response at an extremely low dose. We have examined the effect of nifedipine, as a calcium channel blocker, on morphine-induced hyperalgesia in intact and adrenalectomized rats and on hypothalamic-pituitary-adrenal axis activity induced by ultra-low dose of morphine. To determine the effect of nifedipine on hyperalgesic effect of morphine, nifedipine (2 mg/kg i.p. and 10 microg i.t.) that had no nociceptive effect, was injected concomitant with morphine (1 microg/kg i.p. and 0.01 microg i.t. respectively). The tail-flick test was used to assess the nociceptive threshold, before and 30, 60, 120, 180, 240 and 300 min after drug administration. The data showed that low dose morphine systemic administration could produce hyperalgesic effect in adrenalectomized rats equivalent to sham-operated animals while intrathecal injection of morphine only elicited hyperalgesia in sham-operated animals. Nifedipine could block morphine-induced hyperalgesia in sham and adrenalectomized rats and even a mild analgesic effect was observed in the adrenalectomized group which was reversed by corticosterone replacement. Systemic administration of low dose morphine produced significant increase in plasma level of corticosterone. Nifedipine has an inhibitory effect on morphine-induced corticosterone secretion. Thus, the data indicate that dihydropyridine calcium channels are involved in ultra-low dose morphine-induced hyperalgesia and that both the pattern of morphine hyperalgesia and the blockage of it by nifedipine are modulated by manipulation of the hypothalamic pituitary adrenal axis. 相似文献
6.
Background
Outpatient management is appropriate for chronic pilonidal sinuses. Even though there are different surgical treatments for pilonidal sinuses, the outcome may not be uniformly satisfactory. The aim of this paper was to examine the ambulatory treatment of chronic pilonidal sinuses with lateral incision and primary suture.Methods
We present our experience with outpatient management of asymptomatic chronic pilonidal disease. We prospectively studied patients presenting with pilonidal disease from Mar. 20, 2005, to Mar. 20, 2008. All were managed as outpatients. We reviewed presentation, treatment, healing, time off work and recurrences.Results
In all, 150 patients (131 men and 19 women) with chronic pilonidal sinuses underwent ambulatory plain lateral excision and primary repair during the study period. The mean age of patients was 22.1 years. The mean duration of surgery was 18.4 minutes. No general complications occurred. Local complications consisted of 3 wound infections and 4 wound hematomas. No sinus recurrence occurred. The healing rate was fast in all patients.Conclusion
Advantages of ambulatory plain lateral excision and primary repair include immediate treatment, minimal pain and a quick return to normal activities. This method is a simple and effective procedure in the treatment of uncomplicated pilonidal sinuses. 相似文献7.
8.
Behzad Maghsoudi Hossein Haddad Pooya Vatankhah Alireza Rasekhi Abbas Rahimi Jaberi 《Indian Journal of Critical Care Medicine》2015,19(6):359-361
Post-operative quadriplegia is a rarely encountered complication and not previously reported as the initial presentation of tumefactive multiple sclerosis. We present an unusual case of a patient with such manifestation and atypical lesions on brain magnetic resonance imaging. The patient was treated with methyl prednisolone pulse therapy and showed a dramatic response. Uncommon neurologic diseases can have very unusual presentations, which should be taken into consideration when encountered with such patients. Considering this fact will help physicians in better decision-making and proper treatment planning. 相似文献
9.
Sahar Golabi Maryam Adelipour Sara Mobarak Maghsud Piri Maryam Seyedtabib Reza Bagheri Katsuhiko Suzuki Damoon Ashtary-Larky Fatemeh Maghsoudi Mahshid Naghashpour 《Nutrients》2021,13(10)
Vitamin D and zinc are important components of nutritional immunity. This study compared the serum concentrations of 25-hydroxyvitamin D (25(OH)D) and zinc in COVID-19 outpatients with those of potentially non-infected participants. The association of clinical symptoms with vitamin D and zinc status was also examined. A checklist and laboratory examination were applied to collect data in a cross-sectional study conducted on 53 infected outpatients with COVID-19 and 53 potentially non-infected participants. Serum concentration of 25(OH)D were not significantly lower in patients with moderate illness (19 ± 12 ng/mL) than patients with asymptomatic or mild illness (29 ± 18 ng/mL), with a trend noted for a lower serum concentration of 25(OH)D in moderate than asymptomatic or mild illness patients (p = 0.054). Infected patients (101 ± 18 µg/dL) showed a lower serum concentration of zinc than potentially non-infected participants (114 ± 13 µg/dL) (p = 0.01). Patients with normal (odds ratio (OR), 0.19; p ≤ 0.001) and insufficient (OR, 0.3; p = 0.007) vitamin D status at the second to seventh days of disease had decreased OR of general symptoms compared to patients with vitamin D deficiency. This study revealed the importance of 25(OH)D measurement to predict the progression of general and pulmonary symptoms and showed that infected patients had significantly lower zinc concentrations than potentially non-infected participants. 相似文献
10.
Clinical Rheumatology - Osteoarthritis (OA) is a chronic degenerative joint disease with inflammatory component. It is associated with progressive histological alterations and disabling symptoms.... 相似文献