全文获取类型
收费全文 | 552篇 |
免费 | 26篇 |
专业分类
耳鼻咽喉 | 25篇 |
儿科学 | 18篇 |
妇产科学 | 5篇 |
基础医学 | 96篇 |
口腔科学 | 55篇 |
临床医学 | 25篇 |
内科学 | 89篇 |
皮肤病学 | 5篇 |
神经病学 | 21篇 |
特种医学 | 9篇 |
外科学 | 46篇 |
综合类 | 2篇 |
预防医学 | 99篇 |
眼科学 | 12篇 |
药学 | 44篇 |
肿瘤学 | 27篇 |
出版年
2023年 | 7篇 |
2022年 | 7篇 |
2021年 | 33篇 |
2020年 | 15篇 |
2019年 | 17篇 |
2018年 | 21篇 |
2017年 | 8篇 |
2016年 | 11篇 |
2015年 | 12篇 |
2014年 | 24篇 |
2013年 | 33篇 |
2012年 | 54篇 |
2011年 | 54篇 |
2010年 | 22篇 |
2009年 | 15篇 |
2008年 | 37篇 |
2007年 | 40篇 |
2006年 | 31篇 |
2005年 | 16篇 |
2004年 | 39篇 |
2003年 | 19篇 |
2002年 | 23篇 |
2001年 | 8篇 |
2000年 | 9篇 |
1999年 | 6篇 |
1998年 | 2篇 |
1997年 | 1篇 |
1996年 | 2篇 |
1994年 | 1篇 |
1993年 | 1篇 |
1992年 | 2篇 |
1991年 | 3篇 |
1990年 | 1篇 |
1989年 | 2篇 |
1987年 | 1篇 |
1979年 | 1篇 |
排序方式: 共有578条查询结果,搜索用时 15 毫秒
1.
S. S. Bettiol F. J. Radcliff A. L. Hunt J. M. Goldsmid 《Epidemiology and infection》1994,112(2):275-284
The general bacterial flora of 38 Tasmanian SIDS infants was examined together with faecal flora of 134 comparison infants ranging in age from birth to 6 months. The microflora of all specimens received was investigated with special emphasis on the toxigenic Escherichia coli (TEC). Samples were examined for verocytotoxigenic E. coli, free faecal verocytotoxin (FVT), heat labile toxin (LT) and heat stable toxin (ST) producers with the use of a Vero cell assay and commercial kits. The findings of this study revealed a high isolation rate (39%) of TEC from SIDS infants as compared to 1.5% from the healthy comparison infants. Atypical E. coli strains were also identified during the study, including E. coli A-D. An analysis of the same specimens for rotaviral and adenoviral antigens indicated that 30% of the SIDS cases were positive as compared to 20% in the comparison group. 相似文献
2.
Marques da Silva SH Queiroz-Telles F Colombo AL Blotta MH Lopes JD Pires De Camargo Z 《Journal of clinical microbiology》2004,42(6):2419-2424
Paracoccidioidomycosis (PCM) is a systemic fungal disease that is particularly important among individuals living and working in rural areas of endemicity in Latin America. Detection of anti-Paracoccidioides brasiliensis antibodies is of limited value due to false-negative results. Detection of P. brasiliensis-gp43 circulating antigen is a practical approach for a specific diagnosis of the disease. In a previous study we described an inhibition enzyme-linked immunosorbent assay able to detect the 43-kDa P. brasiliensis antigen in sera of 100% of patients with the acute form of PCM and in 95.31 and 100% of patients with the chronic multifocal and unifocal forms of PCM. To investigate its potential application for the follow-up of PCM patients during treatment, antigen levels were monitored at regular intervals for up 8 to 12 months in serum samples from 23 patients. The results showed that treatment with itraconazole resulted in decreasing levels of circulating gp43 that were correlated with the reduction of anti-gp43 antibodies. It was also observed that by the end of 12 months of treatment gp43 levels were <5 microg/ml in all patients. 相似文献
3.
4.
Marcelo M Rossa Thomaz A A Rocha-e-Silva Cristina H B Terruggi Antonio C Tedesco Heloisa S Selistre-de-Araujo Iouri E Borissevich Igor A Degterev 《Pharmacological research》2003,48(4):369-375
The cytotoxicity of two nitroheterocyclic compounds (NHCD), Nitracrine, 1-nitro-9(3'3'-dimethylaminopropylamino) acridine (Polfa, Poland) and Quinifuryl, 2-(5'-nitro-2'-furanyl) ethenyl-4-[N-[4-(N,N-diethylamino)-1'-methylbutyl] carbamoyl] quinoline (Dr. N. M. Sukhova, Institute of Organic Synthesis, Riga, Latvian Republic), towards two lines of leukaemic cells and a line of non-transformed cells, was determined under normoxia conditions. Although both drugs showed significant cytotoxicity to all cell lines (LC(50) for 24h, < or = 2 microM) with that of Nitracrine exceeding Quinifuryl, their toxicity towards murine leukaemia P388 was substantially higher, compared to murine fibroblasts NIH3T3. In addition, the rate of cell death was also two- to three-fold higher in case of P388 cells versus NIH3T3. Interestingly, human erythroleukaemia K562 cells were shown to uptake the drugs 10 min after their addition to the tissue culture medium, while the LC(50) values were reached after a substantial delay of 3h. This delay might be due to the intracellular transformation of drugs required for cell killing. 相似文献
5.
Elma Izze da Silva Magalhes Bianca Rodrigues de Oliveira Lívia Carolina Sobrinho Rudakoff Vitria Abreu de Carvalho Poliana Cristina de Almeida Fonseca Viola Soraia Pinheiro Machado Arruda Carolina Abreu de Carvalho Carla Cristine Nascimento da Silva Coelho Maylla Luanna Barbosa Martins Bragana Heloisa Bettiol Marco Antnio Barbieri Viviane Cunha Cardoso Alcione Miranda dos Santos Renata Bertazzi Levy Antnio Augusto Moura da Silva 《Nutrients》2022,14(15)
Longitudinal studies evaluating the relationship between UPF consumption and the incidence of Metabolic Syndrome (MetS) and its components are still scarce. This study aimed to evaluate the effect of UPF consumption on the incidence of MetS and its components in adults. A prospective study was conducted with 896 participants from the 1978/79 Ribeirão Preto cohort, São Paulo, Brazil. UPF consumption was evaluated in %kcal and %g at ages 23–25 years. Incidence of MetS and its components were estimated at ages 37–39 years, according to the Joint Interim Statement criteria. Poisson regression was used to assess associations, and interactions with sex were investigated. UPF consumption had no association with MetS (%kcal Adjusted PR: 1.00; 95% CI: 0.99–1.01; %g Adjusted PR: 1.00; 95% CI: 0.99–1.01). However, women with higher UPF consumption, in %kcal and %g, had a higher risk of abdominal obesity (%kcal: p = 0.030; %g: p = 0.003); and women with higher UPF consumption, in %g, had a higher risk of low HDL-cholesterol (p = 0.041). For the other components of MetS, no significant associations were observed in either sex. These findings suggest evidence of no association between UPF consumption and MetS; however, consumption of UPF was associated with increased WC and low HDL-c, but only in women. 相似文献
6.
Polyethylene glycol fusion associated with antioxidants: A new promise in the treatment of traumatic facial paralysis
下载免费PDF全文
![点击此处可从《Head & neck》网站下载免费的PDF全文](/ch/ext_images/free.gif)
7.
8.
M. Becatti G. Emmi A. Bettiol E. Silvestri G. Di Scala N. Taddei D. Prisco C. Fiorillo 《Clinical and experimental immunology》2019,195(3):322-333
Behçet’s syndrome (BS) is a complex disease with different organ involvement. The vascular one is the most intriguing, considering the existence of a specific group of patients suffering from recurrent vascular events involving the venous and, more rarely, the arterial vessels. Several clinical clues suggest the inflammatory nature of thrombosis in BS, especially of the venous involvement, thus BS is considered a model of inflammation-induced thrombosis. Unique among other inflammatory conditions, venous involvement (together with the arterial one) is currently treated with immunosuppressants, rather than with anti-coagulants. Although many in-vitro studies have suggested the different roles of the multiple players involved in clot formation, in-vivo models are crucial to study this process in a physiological context. At present, no clear mechanisms describing the pathophysiology of thrombo-inflammation in BS exist. Recently, we focused our attention on BS patients as a human in-vivo model of inflammation-induced thrombosis to investigate a new mechanism of clot formation. Indeed, fibrinogen displays a critical role not only in inflammatory processes, but also in clot formation, both in the fibrin network and in platelet aggregation. Reactive oxygen species (ROS)-derived modifications represent the main post-translational fibrinogen alterations responsible for structural and functional changes. Recent data have revealed that neutrophils (pivotal in the pathogenetic mechanisms leading to BS damage) promote fibrinogen oxidation and thrombus formation in BS. Altogether, these new findings may help understand the pathogenetic bases of inflammation-induced thrombosis and, more importantly, may suggest potential targets for innovative therapeutic approaches. 相似文献
9.
Samir Abdallah Hanna Alfredo Carlos Simões Dornellas de Barros Felipe Eduardo Martins de Andrade Jose Luiz Barbosa Bevilacqua José Roberto Morales Piato Edilson Lopes Pelosi Eduardo Martella João Luis Fernandes da Silva Heloisa de Andrade Carvalho 《International journal of radiation oncology, biology, physics》2014
10.
Maria Heloisa Massola Shimizu Rildo Aparecido Volpini Daniele Canale Weverton Machado Luchi Leila Froeder 《Renal failure》2017,39(1):193-202
Background: Star fruit (SF) is a popular fruit, commonly cultivated in many tropical countries, that contains large amount of oxalate. Acute oxalate nephropathy and direct renal tubular damage through release of free radicals are the main mechanisms involved in SF-induced acute kidney injury (AKI). The aim of this study was to evaluate the protective effect of N-acetylcysteine (NAC) on SF-induced nephrotoxicity due to its potent antioxidant effect.Materials and methods: Male Wistar rats received SF juice (4?mL/100?g body weight) by gavage after a 12?h fasting and water deprivation. Fasting and water deprivation continued for 6?h thereafter to warrant juice absorption. Thereafter, animals were allocated to three experimental groups: SF (n?=?6): received tap water; SF?+?NAC (n?=?6): received NAC (4.8?g/L) in drinking water for 48?h after gavage; and Sham (n?=?6): no interventions. After 48?h, inulin clearance studies were performed to determine glomerular filtration rate. In a second series of experiment, rats were housed in metabolic cages for additional assessments.Results: SF rats showed markedly reduced inulin clearance associated with hyperoxaluria, renal tubular damage, increased oxidative stress and inflammation. NAC treatment ameliorated all these alterations. Under polarized light microscopy, SF rats exhibited intense calcium oxalate birefringence crystals deposition, dilation of renal tubules and tubular epithelial degeneration, which were attenuate by NAC therapy.Conclusions: Our data show that therapeutic NAC attenuates renal dysfunction in a model of acute oxalate nephropathy following SF ingestion by reducing oxidative stress, oxaluria, and inflammation. This might represent a novel indication of NAC for the treatment of SF-induced AKI. 相似文献