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B Ulfhake K Carlsson K Mossberg U Arvidsson P J Helm 《Journal of neuroscience methods》1991,40(1):39-48
This paper describes the implementation of an ultraviolet (UV) laser (Spectra Physics 171-18 with 3 lines: 334, 351 and 364 nm in UV) as light source for fluorescence confocal scanning microscopy. With this instrument it is possible to use fluorophores not previously available for confocal laser microscopical imaging of fluorophores such as fluoro-gold and AMCA. In the study we show confocal laser microscopical imaging of fluorescent motoneurons labelled by retrograde transport of fluoro-gold and AMCA-fluorescent axon terminals labelled with antisera against immunogenes as thyrotropin-releasing hormone (TRH) and calcitonin gene-related peptide (CGRP). These two fluorophores may be recorded simultaneously or separately by using a filter that suppresses the emission of one of the fluorophores. The described instrument should also be useful in applications involving detection of monoamines by the Falck-Hillarp technique, as well as measurements of cytosolic free calcium by indicators such as Fura-2 and Indo-1. Measurements performed in reflected and fluorescence light indicated that the resolution along the optical axis improved by about 25% when UV (351 nm) is used instead of visible light (514 nm). This figure is close to that expected on theoretical basis. There are, however, also serious problems related to the use of UV excitation. Firstly, objectives must be selected based on their UV transmission properties. Secondly, chromatic aberration may cause a substantial focal shift between illuminating and emitted light, calling for a flexible instrumental design in order to allow for compensation. As shown here, this problem can be circumvented by using reflecting objectives but at a price of lower resolution compared with high-aperture refracting objectives. 相似文献
3.
A synchronous occurrence of large bowel adenocarcinoma and extragenital malignant mixed mesodermal tumour (MMMT) is reported. This case represents the sixth extragenital MMMT reported in the literature. 相似文献
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Oberstabsarzt B. Hossfeld M. Helm G. Hölldobler L. Lampl 《Notfall & Rettungsmedizin》2005,8(3):201-206
Zusammenfassung Die Teilnahme der Bundeswehr an internationalen Missionen erfordert ein an die Bedingungen militärischer Einsätze angepasstes Konzept zur intensivmedizinischen Repatriierung. Die umfassende Transportkapazität des auf den Airbus A-310 gestützten Systems von bis zu 44 liegenden Patienten bedingte bereits mehrfach den Einsatz im Rahmen ziviler Großschadensereignisse. Der Transport der häufig vital gefährdeten Patienten erfordert sowohl eine dem Inlandsstandard anzupassende medizintechnische Ausstattung der Luftfahrzeuge als auch entsprechend qualifiziertes medizinisches Begleitpersonal, das aufgrund der Sitzplätze zahlenmäßig begrenzt ist. Dieser Umstand verlangt vom Personal Umsicht bei der Betreuung von zeitgleich mehreren Patienten sowie Befähigung zum eigenständigen Arbeiten. Die Patienten-Transport-Einheiten (PTE) entsprechen in der technischen Ausstattung dem Intensivbehandlungsplatz einer modernen Klinik und gewährleisten auch über eine längere Transportzeit eine Intensivtherapie auf höchstem Niveau. Die Arbeit mit dieser Ausrüstung, die Besonderheiten des Langstreckenlufttransportes und die spezielle Situation des militärischen Einsatzes stellen zusätzliche Anforderungen an das Personal. Um dem gerecht zu werden, erfolgt, ergänzend zur täglichen Arbeit im Rettungsdienst, in den Notaufnahmen und auf den Intensivstationen der Bundeswehrkrankenhäuser eine spezielle Schulung von Rettungsassistenten und Ärzten am Flugmedizinischen Institut der Luftwaffe. 相似文献
6.
B. S. Kamps H. -R. Brodt S. Staszewski L. Bergmann E. B. Helm 《Journal of molecular medicine (Berlin, Germany)》1994,72(4):283-287
The clinical history of 1538 HIV positive patients was analyzed on the basis of the new CDC classification system of HIV disease and AIDS. This classification system combines three CD4 cell categories (1, 2, and 3) with three clinical categories (A, B, and C) into nine subgroups AI–C3. We examined the overall survival for all subgroups and the AIDS-free survival for subgroups Al–B3. AIDS-free survival for patients in subgroups Al, A2, and B1 was considerably longer than survival in patients from subgroups A3, B2, and B3 (P < 0.0001). According to these findings, the new CDC classification system could be simplified into three stages, stage I and II comprising the above mentioned six subgroups, and stage III comprising clinical AIDS defining categories C1, C2, and C3. These three stages correspond to different periods in the management of HIV positive patients, i.e., period of observation, period of prophylaxis, and period of treatment.Abbreviations AIDS
acquired immunodeficiency syndrome
- CDC
Centers for Disease Control
- HIV
Human immunodeficiency virus
Correspondence to: E.B. Helm 相似文献
7.
A survey to determine the status of burn rehabilitation services in the United States was developed and sent to 186 burn treatment facilities. The facilities were divided into four groups based upon number of admissions per year (0 to 80, 81 to 120, 121 to 200, and 200+). Completed surveys were received from 114 facilities. Results indicated that burn facilities of different sizes were consistent with respect to the severity of burn injuries treated, the length of hospitalization for acute injuries, and the duration of physician follow-up after discharge. Burn facilities with more admissions were more likely to report (1) organized outpatient burn rehabilitation programs, (2) available specialized burn rehabilitation personnel, (3) regular interdisciplinary inpatient staffing conferences and outpatient clinics, and (4) structured educational activities for staff and Full-time equivalent burn rehabilitation personnel were equally represented across facilities of different sizes. The overall results suggest that there have been substantial improvements in the comprehensiveness of burn rehabilitation care since a previous survey in 1983. Minimum guidelines for burn rehabilitation are suggested based upon the relative consistency between burn facilities indicated by the survey results. 相似文献
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Dr. M. Bernhard W. Zink M. Sikinger A. Aul M. Helm T. S. Mutzbauer S. Doll A. Völkl A. Gries 《Notfall & Rettungsmedizin》2005,8(6):399-407
Prehospital emergency medicine in Germany is based on a specially trained physician-staffed system, in order to realize a differentiate therapy at the scene. In the last years, the special education and the qualification were more and more discussed after the determination of deficits in the prehospital management of special emergency situations. In the presented paper we described the concept and organization of a practice-oriented training model of invasive emergency techniques, as like as the emergency cricothyrotomy, the thoracic tube and the intraosseous access. The relevance and the efficacy are discussed based on an evaluation of the participants. Practice-oriented training models seem to be adequate instruments in order to close the leak in educational programs and can help to improve the qualification of the physician-staffed system, generally. 相似文献
10.
In a retrospective study of 137 biopsy specimens of skin from 137 patients (69 men and 68 women) that had been obtained between 1972 and 1989 at our institution and that had perivascular and periappendageal lymphocytic infiltrates characteristic of those described as benign lymphocytic infiltrate (BLI), we determined the specificity of the histologic diagnosis and the correlation with clinical data. The final diagnoses, based on clinical and laboratory data and histologic findings, were BLI (59), possible BLI (7), lupus erythematosus (LE) (12), possible LE (7), procainamide-induced LE (1), insect bites (9), possible insect bites (3), polymorphous light eruption (4), lymphocytoma (4), urticaria (4), and indeterminate or miscellaneous diagnoses (27). BLI is a clinical and histologic syndrome that can be heterogeneous in origin. We recommend careful evaluation to exclude other disorders such as LE, polymorphous light eruption, lymphocytoma, and insect bites. Direct immunofluorescence microscopy and immunophenotypic studies may help distinguish BLI from LE. 相似文献