全文获取类型
收费全文 | 25304篇 |
免费 | 1997篇 |
国内免费 | 49篇 |
专业分类
耳鼻咽喉 | 158篇 |
儿科学 | 946篇 |
妇产科学 | 756篇 |
基础医学 | 3625篇 |
口腔科学 | 442篇 |
临床医学 | 3333篇 |
内科学 | 4448篇 |
皮肤病学 | 310篇 |
神经病学 | 2954篇 |
特种医学 | 626篇 |
外科学 | 2198篇 |
综合类 | 283篇 |
一般理论 | 46篇 |
预防医学 | 3113篇 |
眼科学 | 417篇 |
药学 | 1954篇 |
中国医学 | 28篇 |
肿瘤学 | 1713篇 |
出版年
2023年 | 234篇 |
2022年 | 274篇 |
2021年 | 519篇 |
2020年 | 393篇 |
2019年 | 592篇 |
2018年 | 648篇 |
2017年 | 522篇 |
2016年 | 553篇 |
2015年 | 627篇 |
2014年 | 897篇 |
2013年 | 1277篇 |
2012年 | 1793篇 |
2011年 | 1865篇 |
2010年 | 1009篇 |
2009年 | 939篇 |
2008年 | 1563篇 |
2007年 | 1687篇 |
2006年 | 1666篇 |
2005年 | 1560篇 |
2004年 | 1516篇 |
2003年 | 1374篇 |
2002年 | 1315篇 |
2001年 | 319篇 |
2000年 | 278篇 |
1999年 | 276篇 |
1998年 | 279篇 |
1997年 | 244篇 |
1996年 | 204篇 |
1995年 | 197篇 |
1994年 | 157篇 |
1993年 | 167篇 |
1992年 | 168篇 |
1991年 | 147篇 |
1990年 | 135篇 |
1989年 | 122篇 |
1988年 | 108篇 |
1987年 | 102篇 |
1986年 | 88篇 |
1985年 | 93篇 |
1984年 | 88篇 |
1983年 | 88篇 |
1982年 | 104篇 |
1981年 | 76篇 |
1980年 | 86篇 |
1979年 | 70篇 |
1978年 | 64篇 |
1977年 | 63篇 |
1976年 | 69篇 |
1975年 | 64篇 |
1974年 | 60篇 |
排序方式: 共有10000条查询结果,搜索用时 9 毫秒
1.
2.
3.
4.
5.
Torbj?rn Karlsson 《Upsala journal of medical sciences》2015,120(4):257-262
Background. Haemophagocytic lymphohistiocytosis (HLH) is a rare clinical syndrome characterized by fever, hepatosplenomegaly, cytopenia, and progressive multiple-organ failure. HLH in adults is often secondary to autoimmune diseases, cancer, or infections in contrast to familial HLH. Treatment of secondary HLH is directed against the triggering disease in addition to immunosuppressive therapy, the latter commonly according to the HLH-2004 protocol.Methods. We conducted a retrospective study to identify triggering diseases, disease-specific and immunosuppressive therapy administered, and prognosis in adult patients with secondary HLH. Patient data were collected from October 2010 to January 2015.Results. Ten adult patients with secondary HLH were identified. Seven were men, and the median age at diagnosis was 62 years. Five cases were triggered by malignant disease and five by infection. The median patient fulfilled five of the eight HLH-2004 diagnostic criteria. All patients fulfilled the criteria fever, cytopenia, and ferritin >500 µg/L. Median time from hospital admission to HLH diagnosis was 20 days. Four patients received immunosuppressive therapy according to the HLH-2004 protocol. The prognosis was dismal, especially for the patients with malignancy-associated HLH, of whom all died.Conclusion. HLH should be suspected in patients who present with fever, cytopenia, and ferritin >500 µg/L. Secondary HLH has a dismal prognosis. None of the patients with HLH triggered by malignancy survived. Achieving remission of the triggering disease seems to be important for a favourable outcome as, in all surviving patients, the haemophagocytic syndrome resolved after remission of the underlying infection. 相似文献
6.
7.
Oliver Sartor MD Daniel Heinrich MD Neil Mariados MD Maria José Méndez Vidal MD Daniel Keizman MD Camilla Thellenberg Karlsson MD Avivit Peer MD Giuseppe Procopio MD Stephen J. Frank MD Kalevi Pulkkanen MD Eli Rosenbaum MD Stefano Severi MD José Trigo MD Lucia Trandafir MD Volker Wagner MD Rui Li MS Luke T. Nordquist MD 《The Prostate》2019,79(14):1683-1691
8.
Mary Ann Richardson Helen M Chao Laura L Read James D Clelland Raymond F Suckow 《American journal of medical genetics. Part B, Neuropsychiatric genetics》2006,(2):195-197
Phenylketonuria (PKU), an inborn error of phenylalanine metabolism, has been shown to be a risk factor for tardive dyskinesia (TD). In male psychiatric patients there was a significant relationship between TD and measures of plasma phenylalanine following ingestion of a standardized phenylalanine dose that was indicative of higher brain availability of phenylalanine in patients with TD. In addition, a medical food formulation consisting of branched chain amino acids, which compete with phenylalanine for transport across the blood-brain barrier, has been demonstrated to be an efficacious treatment for TD. Cumulatively these findings suggested that TD was related to phenylalanine metabolism and thus that sequence variants in the gene for phenylalanine hydroxylase (PAH), the rate-limiting enzyme in the catabolism of phenylalanine, could be associated with TD susceptibility. Genetic screening of PAH in a group of 123 psychiatric patients revealed ten sequence polymorphisms and two mutations, but none appeared to be a significant risk factor for TD. 相似文献
9.
Helen Mashek MD Barbara Licznerski MD Stephanie Pincus MD 《International journal of dermatology》1997,36(4):276-278
A 33-year-old African woman was evaluated for tender nodules on her feet. Accompanied by her four children, she had recently immigrated from Somalia. Before her immigration, she resided in a Kenyan refugee camp for approximately 1 year, where she walked barefoot in sand and dirt. The patient stated that she and her four children, as well as many people living in the same compound, had similar, tender lesions on their feet. Her children were "treated" by their grandmother, who removed the contents of their lesions with a safety pin.
On physical examination the patient had numerous tender, isolated, and clustered hyperkeratotic, crusted papules, measuring 4–6 mm, on the plantar and periungual surfaces. Several lesions were ulcerated (Figs 1 and 2). The hyperkeratotic masses were debrided with a surgical blade. An intact, white, coiled structure was curetted from each papule, leaving numerous empty crater-like lesions (Fig. 3), which were identified on histologic sections as Tunga penetrans. Microscopic examination of unstained specimens showed branching, thin, translucent tubular structures with numerous eggs. Ring-shaped cross-sections of the organism's respiratory and digestive tracts were seen on hematoxylin and eosin stain (Fig. 4).
The patient received a 10-day course of dicloxacillin and topical bacitracin ointment. All lesions were healed within 1 week of therapy. 相似文献
On physical examination the patient had numerous tender, isolated, and clustered hyperkeratotic, crusted papules, measuring 4–6 mm, on the plantar and periungual surfaces. Several lesions were ulcerated (Figs 1 and 2). The hyperkeratotic masses were debrided with a surgical blade. An intact, white, coiled structure was curetted from each papule, leaving numerous empty crater-like lesions (Fig. 3), which were identified on histologic sections as Tunga penetrans. Microscopic examination of unstained specimens showed branching, thin, translucent tubular structures with numerous eggs. Ring-shaped cross-sections of the organism's respiratory and digestive tracts were seen on hematoxylin and eosin stain (Fig. 4).
The patient received a 10-day course of dicloxacillin and topical bacitracin ointment. All lesions were healed within 1 week of therapy. 相似文献
10.