全文获取类型
收费全文 | 1372424篇 |
免费 | 118939篇 |
国内免费 | 9287篇 |
专业分类
耳鼻咽喉 | 17126篇 |
儿科学 | 43330篇 |
妇产科学 | 36835篇 |
基础医学 | 187172篇 |
口腔科学 | 36875篇 |
临床医学 | 125235篇 |
内科学 | 282824篇 |
皮肤病学 | 32338篇 |
神经病学 | 112072篇 |
特种医学 | 57160篇 |
外国民族医学 | 285篇 |
外科学 | 214902篇 |
综合类 | 39531篇 |
现状与发展 | 16篇 |
一般理论 | 416篇 |
预防医学 | 109336篇 |
眼科学 | 28919篇 |
药学 | 97881篇 |
38篇 | |
中国医学 | 4890篇 |
肿瘤学 | 73469篇 |
出版年
2018年 | 14812篇 |
2017年 | 12049篇 |
2016年 | 14048篇 |
2015年 | 16214篇 |
2014年 | 22226篇 |
2013年 | 32110篇 |
2012年 | 39397篇 |
2011年 | 42323篇 |
2010年 | 26868篇 |
2009年 | 25919篇 |
2008年 | 38571篇 |
2007年 | 40939篇 |
2006年 | 41798篇 |
2005年 | 40247篇 |
2004年 | 37871篇 |
2003年 | 36770篇 |
2002年 | 34636篇 |
2001年 | 66655篇 |
2000年 | 68465篇 |
1999年 | 57093篇 |
1998年 | 16971篇 |
1997年 | 15276篇 |
1996年 | 16226篇 |
1995年 | 16417篇 |
1994年 | 15254篇 |
1993年 | 14230篇 |
1992年 | 47183篇 |
1991年 | 45828篇 |
1990年 | 44045篇 |
1989年 | 41870篇 |
1988年 | 38810篇 |
1987年 | 38113篇 |
1986年 | 35885篇 |
1985年 | 34646篇 |
1984年 | 26374篇 |
1983年 | 22109篇 |
1982年 | 13858篇 |
1981年 | 12456篇 |
1980年 | 11718篇 |
1979年 | 23550篇 |
1978年 | 17083篇 |
1977年 | 14390篇 |
1976年 | 13185篇 |
1975年 | 13726篇 |
1974年 | 16097篇 |
1973年 | 15399篇 |
1972年 | 14180篇 |
1971年 | 13039篇 |
1970年 | 11881篇 |
1969年 | 11101篇 |
排序方式: 共有10000条查询结果,搜索用时 46 毫秒
1.
2.
本文通过对《中医基本名词术语中英对照国际标准》和《WHO西太平洋地区传统医学名词术语国际标准》舌诊术语进行比较,分析两部标准中舌诊术语英译的优缺点,提出更适宜优先选择作为中医舌诊术语英译标准的方案,以期为中医名词术语标准化工作提供参考。 相似文献
3.
目的探讨脊髓小脑共济失调2型(SCA2)致病基因ATXN2异常等位基因中间重复个体的表型和分子遗传学特点。方法针对2005—2018年中日友好医院神经科运动障碍与神经遗传病研究中心收集的1383个常染色体显性遗传共济失调家系的先证者和部分家系成员,采用荧光标记毛细管电泳片段分析方法进行动态突变检测,对携带ATXN2基因中间重复的个体进行临床表型和遗传特征分析。结果共检出163个家系(包含先证者和家系成员共203人)携带异常扩展的ATXN2基因CAG重复序列,其中93个家系中有107例的异常扩展等位基因重复次数在29~34次之间。在其中的20个亲子对中,父系遗传16个,异常等位基因的代间扩展增加0~28次,母系遗传4个,异常等位基因的代间扩展增加0~4次。结论对于临床拟诊SCA2家系患者,需对其亲代或成年子代个体进行ATXN2基因检测,以免漏诊。动态突变基因检测有助于识别中间重复的个体,对明确家系致病基因和遗传咨询至关重要。 相似文献
4.
Zeyu Li Erwei Hao Rui Cao Si Lin Linghui Zou Tianyan Huang Zhengcai Du Xiaotao Hou Jiagang Deng 《中草药(英文版)》2022,14(4):479-493
Zedoary tumeric (Curcumae Rhizoma, Ezhu in Chinese) has a long history of application and has great potential in the treatment of liver cancer. The anti liver cancer effect of zedoary tumeric depends on the combined action of multiple pharmacodynamic substances. In order to clarify the specific mechanism of zedoary tumeric against liver cancer, this paper first analyzes the mechanism of its single pharmacodynamic substance against liver cancer, and then verifies the joint anti liver cancer mechanism of its "pharmacodynamic group". By searching the research on the anti hepatoma effect of active components of zedoary tumeric in recent years, we found that pharmacodynamic substances, including curcumol, zedoarondiol, curcumenol, curzerenone, curdione, curcumin, germacrone, β-elemene, can act on multi-target and multi-channel to play an anti hepatoma role. For example, curcumin can regulate miR, GLO1, CD133, VEGF, YAP, LIN28B, GPR81, HCAR-1, P53 and PI3K/Akt/mTOR, HSP70/TLR4 and NF-κB. Wnt/TGF/EMT, Nrf2/Keap1, JAK/STAT and other pathways play an anti hepatoma role. Network pharmacological analysis showed that the core targets of the "pharmacodynamic group" for anti-life cancer are AKT1, EGFR, MAPK8, etc, and the core pathways are neuroactive live receiver interaction, nitrogen metabolism, HIF-1 signaling pathway, etc. At the same time, by comparing and analyzing the relationship between the specific mechanisms of pharmacodynamic substance and "pharmacodynamic group", it is found that they have great reference significance in target, pathway, biological function, determination of core pharmacodynamic components, formation of core target protein interaction, in-depth research of single pharmacodynamic substance, increasing curative effect and so on. By analyzing the internal mechanism of zedoary tumeric pharmacodynamic substance and "pharmacodynamic group" in the treatment of liver cancer, this paper intends to provide some ideas and references for the deeper pharmacological research of zedoary tumeric and the relationship between pharmacodynamic substance and "pharmacodynamic group". 相似文献
5.
6.
Journal of Behavioral Medicine - Evidence supports the use of graphic warnings to educate the public about the health harms of smoking and suggests warnings eliciting negative emotional responses... 相似文献
7.
Qian Zhang Larry D. Mesner Gina M. Calabrese Naomi Dirckx Zhu Li Angela Verardo Qian Yang Robert J. Tower Marie-Claude Faugere Charles R. Farber Thomas L. Clemens 《The Journal of clinical investigation》2021,131(7)
Bone mineral density (BMD) is a highly heritable predictor of osteoporotic fracture. GWAS have identified hundreds of loci influencing BMD, but few have been functionally analyzed. In this study, we show that SNPs within a BMD locus on chromosome 14q32.32 alter splicing and expression of PAR-1a/microtubule affinity regulating kinase 3 (MARK3), a conserved serine/threonine kinase known to regulate bioenergetics, cell division, and polarity. Mice lacking Mark3 either globally or selectively in osteoblasts have increased bone mass at maturity. RNA profiling from Mark3-deficient osteoblasts suggested changes in the expression of components of the Notch signaling pathway. Mark3-deficient osteoblasts exhibited greater matrix mineralization compared with controls that was accompanied by reduced Jag1/Hes1 expression and diminished downstream JNK signaling. Overexpression of Jag1 in Mark3-deficient osteoblasts both in vitro and in vivo normalized mineralization capacity and bone mass, respectively. Together, these findings reveal a mechanism whereby genetically regulated alterations in Mark3 expression perturb cell signaling in osteoblasts to influence bone mass. 相似文献
8.
9.
10.
Background:We aim to evaluate the efficiency of Raman spectroscopy (RS) in diagnosing suspected patients with intrahepatic cholangiocarcinoma (ICC), manifested by diagnostic sensitivity, specificity, and accuracy.Methods:We will research widely the articles concerning the use of RS in ICC through authenticated database including PubMed/Medline, EMBASE, Web of Science, Ovid, Web of Knowledge, Cochrane Library, and CNKI between January 2012 and November 2020, retrieving at least 1500 spectra with strict criteria. This study will be carried out in accordance to Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. We are going to summarize the test performance using random effects models.Results:Based on the pooled sensitivity, specificity, and diagnostic accuracy, we intend to provide the relative diagnostic efficiency in ICC through RS.Conclusion:Through this systematic review and meta-analysis, we intend to provide the pooled sensitivity, specificity and diagnostic accuracy of RS in the diagnosis of suspected ICC. Other parameters like positive likelihood ratios (LR), negative LR, diagnostic odds ratio (DOR), and area under curve (AUC) of the summary receiver operating characteristics (SROC) curve will also be calculated and related figures will be drawn to help illustrate the efficacy of RS in the diagnosis of ICC. 相似文献