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排序方式: 共有188条查询结果,搜索用时 15 毫秒
1.
Berlier W Bourlet T Lawrence P Hamzeh H Lambert C Genin C Verrier B Dieu-Nosjean MC Pozzetto B Delézay O 《Journal of medical virology》2005,77(4):465-474
X4 and R5 HIV strains are present in the semen of men infected with HIV but R5 isolates are transmitted preferentially. The role of human epithelial cells in this selection is addressed. Three human cervical cell lines-CaSki, SiHa, and HEC1A-and normal human vaginal cells from HIV-negative donors were characterized for HIV receptor expression and incubated with X4 and R5 laboratory-adapted strains or primary isolates. The infection was assessed by detection of intracellular HIV DNA. The three cell lines were shown to express on their surface the CXCR4 and GalCer molecules, but not the CD4 and CCR5 ones. The three cell lines and normal human vaginal cells were found to be selectively permissive to X4 HIV entry; the preincubation of the cell lines with rhSDF-1 inhibited this infection. The detection of the intracellular proviral DNA in the cell lines and in normal human vaginal cells demonstrated a selective integration of X4 strains. Additional experiments showed that no extracellular RNA was detected in the supernatants of HEC1A cells infected by X4 isolates either after 18 days of culture or after incubation with PHA-stimulated PBMCs and that no transmission occurred after co-culture between infected HEC1A cells and PHA-stimulated PBMCs. These results suggest specific sequestration of X4 strains by genital epithelial cells, which could explain, at least in part, the HIV tropism selection process during sexual intercourse. 相似文献
2.
L Morley T Tang E Yasmin R Hamzeh AJ Rutherford AH Balen 《Human fertility (Cambridge, England)》2012,15(3):134-139
This randomized controlled trial investigated whether delaying human chorionic gonadotrophin hormone (hCG) administration within an IVF cycle impacts upon clinical outcomes. Participants included 125 women undergoing IVF/ICSI cycles at Leeds Centre for Reproductive Medicine. Subjects were aged 20-36 years, body mass index (BMI) 20-30?kg/m(2) with a normal FSH level (<8 IU/l). Administration of hCG took place 35-36?h prior to oocyte retrieval when there were ≥3 follicles ≥17?mm in diameter (Group A), delayed by 1 day (Group B) or 2 days (Group C). Outcomes included the number of oocytes retrieved per cycle, fertilization rate and live birth rate. On the day of oocyte retrieval, women in Groups B and C had significantly more mature follicles than Group A, although the number of oocytes retrieved did not differ (median = 12 in each group). Fertilization rates and embryo quality were comparable between groups. Pregnancies and live births per cycle were higher in Groups B and C (A = 30.8%, B = 54.1%, C = 38.7%; A = 17.9%, B = 27.0%, C = 25.8%), but did not reach statistical significance. Delaying hCG administration had no significant negative impact upon morphological quality of embryos, availability of surplus embryos for freezing or pregnancy outcomes. Postponing hCG may enable increased flexibility of cycle scheduling to avoid weekend procedures. 相似文献
3.
Hamzeh Kayhanian Emily Goode Francesco Sclafani Joo Ern Ang Marco Gerlinger David Gonzalez de Castro Scott Shepherd Clare Peckitt Sheela Rao David Watkins Ian Chau David Cunningham Naureen Starling 《Clinical colorectal cancer》2018,17(1):e69-e76
Background
Somatic v-Raf murine sarcoma viral oncogene homolog B (BRAF) mutation, present in approximately 10% of metastatic colorectal cancer (mCRC) cases, is associated with poor prognosis. Patient outcome outside of clinical trials has only been reported in small series. We report real-world data on treatment and survival for BRAF-mutated (MT) patients at a single tertiary center, compared with a matched BRAF wild type (WT) control group.Patients and Methods
All colorectal cancer patients tested for BRAF mutation, from October 2010 to November 2014 were identified. BRAF-MT mCRC cases were compared with an age and sex-matched BRAF-WT control group. Clinicopathological data were collected and survival calculated using the Kaplan–Meier method and comparisons made using Cox regression.Results
Forty-three of 503 patients (8.5%) tested had BRAF-MT mCRC and were compared with 88 BRAF-WT controls. Median overall survival (mOS) was 18.2 months for BRAF-MT and 41.1 months for BRAF-WT mCRC patients (hazard ratio, 2.74; 95% confidence interval, 1.60-4.70; P < .001). Progression-free survival for BRAF-MT and WT patients, respectively, was: 8.1 months versus 9.2 months (P = .571) first-line, 5.5 months versus 8.3 months (P = .074) second-line, and 1.8 months versus 5.6 months (P = .074) third-line. Treatment using sequential fluoropyrimidine-based doublet chemotherapy was similar between both groups. Anti-epidermal growth factor receptor (EGFR) therapy was mainly given third-line with progressive disease in 90% (n = 9 of 10) of BRAF-MT patients at first restaging.Conclusion
In this case-control study, the poor mOS of BRAF-MT mCRC was associated with reduced treatment benefit beyond first-line. Sequential doublet chemotherapy remains a reasonable option in appropriately selected patients. BRAF-MT patients did not benefit from anti-EGFR therapy in this study. Recruitment to clinical trials is recommended to improve outcomes in BRAF-MT mCRC. 相似文献4.
Nikoo Hamzeh Sasan Moghimi Golshan Latifi Massood Mohammadi Nassim Khatibi Shan C. Lin 《国际眼科》2015,8(6):1151-1155
AIM: To assess lens thickness measurements with anterior segment-optical coherence tomography (AS-OCT) in comparison with A-scan ultrasonography (A-scan US).
METHODS: There were 218 adult subjects (218 eyes) aged 59.2±9.2y enrolled in this prospective cross-sectional study. Forty-three eyes had open angles and 175 eyes had narrow angles. Routine ophthalmic exam was performed and nuclear opacity was graded using the Lens Opacities Classification System III (LOCS III). Lens thickness was measured by AS-OCT (Visante OCT, Carl Zeiss Meditec, Dublin, CA, USA). The highest quality image was selected for each eye and lens thickness was calculated using ImageJ software. Lens thickness was also measured by A-scan US.
RESULTS: Interclass correlations showed a value of 99.7% for intra-visit measurements and 95.3% for inter-visit measurements. The mean lens thickness measured by AS-OCT was not significantly different from that of A-scan US (4.861±0.404 vs 4.866±0.351 mm, P=0.74). Lens thickness values obtained from the two instruments were highly correlated overall (Pearson correlation coefficient=0.81, P<0.001), and in all LOCS III specific subgroups except in grade 5 of nuclear opacity. Bland-Altman analysis revealed a 95% limit of agreement from -0.45 to 0.46 mm. Lens thickness difference between the two instruments became smaller as the lens thickness increased and AS-OCT yielded smaller values than A-scan US in thicker lens (β=-0.29, P<0.001)
CONCLUSION: AS-OCT-derived lens thickness measurement is valid and comparable to the results obtained by A-scan US. It can be used as a reliable noncontact method for measuring lens thickness in adults with or without significant cataract. 相似文献
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Seyed Hamzeh Hosseini Ali Ghaemian Elaheh Mehdizadeh Haleh Ashraf 《International journal of psychiatry in clinical practice》2014,18(3):175-181
Objective. To quantify the adverse influence of depression and anxiety assessed at the time of myocardial infarction, on the quality of life 5 years after the infarction. Methods. The Beck Depression Inventory (BDI) and the State-Trait Anxiety Inventory (STAI) were completed in a group of 196 patients admitted in the hospital following non-fatal myocardial infarction, and the SF-12 quality of life questionnaire was administered during the 5- year follow-up. Results. Regression analysis showed a strong association between baseline depression and QoL in both the physical and mental domains; the higher the depression scores, the poorer the QoL. However, anxiety present at the time of myocardial infarction did not predict later QoL. Conclusions. Depression but not anxiety following MI predicts longer-term quality of life in myocardial infarction survivors. 相似文献
9.
In this work, an outstanding nano-structured composite electrode is fabricated through the co-deposition of Co(OH)2 nanoplates and porous reduced GO (p-rGO) nanosheets onto Ni foam (NF). Through field emission scanning electron microscopy and transmission electron microscopy observations, it was confirmed that porous reduced graphene oxide sheets are completely wrapped by uniform hexagonal Co(OH)2 plates. Due to the unique architecture of both components of the prepared composite, a high surface area of 234.7 m2 g−1 and mean pore size of 3.65 nm were observed for the Co(OH)2@p-rGO composite. The constructed Co(OH)2@p-rGO/NF composite electrode shows higher energy storage capability compared to that of Co(OH)2/NF and p-rGO/NF electrodes. The Co(OH)2/NF electrode shows specific capacitances of 902 and 311 F g–1 at 5 and 30 A g–1, while the Co(OH)2@p-rGO/NF electrode delivers 1688 and 1355 F g–1 under the same current loads, respectively. Furthermore, when the current load was increased from 1 to 30 A g–1, 74.5% capacitance retention was observed for the Co(OH)2@p-rGO/NF electrode, indicating its outstanding high-power capability, while the Co(OH)2/NF electrode retained only 38.5% of its initial capacitance. The fabricated Co(OH)2@p-rGO/NF//rGO/NF ASC device shows an areal capacitance of 3.29 F cm−2, cycling retention of 91.2% after 4500 cycles at 5 A g−1 and energy density of 68.7 W h kg−1 at a power density of 895 W kg−1. The results of electrochemical tests prove that Co(OH)2@p-rGO/NF exhibits good performance as a positive electrode for use in an asymmetric supercapacitor device. The prepared porous composite electrode is thus a promising candidate for use in supercapacitor applications.Fabrication mechanism of a ready-to-use Co(OH)2@p-rGO/NF electrode: (a) base generation step, (b) electrophoretic deposition of rGO onto NF and (c) chemical formation of Co(OH)2 on rGO. 相似文献
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