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排序方式: 共有1116条查询结果,搜索用时 15 毫秒
1.
K H Orend N Zarbis H Schelzig G Halter G Lang L Sunder-Plassmann 《European journal of vascular and endovascular surgery》2007,34(6):666-672
OBJECTIVES: To present a single centers' 7-year experience in the endovascular treatment of acute traumatic lesions of the descending thoracic aorta (ATL of the DTA). MATERIALS & METHODS: Between March 1999 and December 2006, 34 consecutive acute traumatic lesions of the descending aorta (23 men, mean age 44 years) were treated endovascularly. Stentgrafts used were TAG Excluder, Zenith TX2 and Talent. In 23 patients the Left Subclavian Artery (LSA) was covered. Mean procedural duration was 20 to 75 minutes. RESULTS: Exclusion of the rupture site was achieved in all cases with no conversion to open surgery. Overall 30-day mortality was 8.8%. Two patients died on post operative day (pod) 1 and one on pod 22 from cranial injuries. No death or neurological deficit related to the endovascular treatment was reported. Four type I endoleaks required treatment either by balloon reexpansion (n=2) or by additional stentgraft implantation (n=2). In two patients the stentgraft collapsed totally several days postoperatively. Two patients required secondary surgical procedures (iliac access complication and revascularisation of the left subclavian artery n=1). The average follow-up was 43.8 months (1-93 months). No stentgraft related abnormality has been subsequently documented. CONCLUSIONS: The endovascular treatment of ATL of the DTA may offer the best means of therapy in a polytrauma patient. 相似文献
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We used arthrotomography to study the glenoid labrum in 114 patients. Sixty-nine of the patients had anatomic instability of the shoulder (including recurrent dislocation and subluxation of the shoulder), and 45 patients had functional instability of the shoulder (denoted by chronic pain, clicking of the joint, and the sensation that an unstable condition exists without the objective signs of it). Labral tears were revealed arthrotomographically in 86% of the patients with anatomic instability, while only 40% of the patients with functional instability had labral abnormalities, and these were primarily of minor severity. Fifty-six patients (44 of whom had anatomic instability; 12, functional instability) required surgery. The surgical findings were correlated with the arthrotomographic findings, and no false-positive results were revealed. However, arthrotomography demonstrated only part of the pathologic condition of two patients. These results confirm that there is a strong correlation between labral pathologic conditions and anatomic instability of the shoulder. Arthrotomographic studies have a great impact on the selection of therapy in cases of both anatomic and functional instability of the shoulder. 相似文献
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Linkage of the MHC to familial multiple sclerosis suggests genetic heterogeneity. The Multiple Sclerosis Genetics Group 总被引:5,自引:0,他引:5
Haines JL; Terwedow HA; Burgess K; Pericak-Vance MA; Rimmler JB; Martin ER; Oksenberg JR; Lincoln R; Zhang DY; Banatao DR; Gatto N; Goodkin DE; Hauser SL 《Human molecular genetics》1998,7(8):1229-1234
Multiple sclerosis (MS) is a demyelinating autoimmune disease of the
central nervous system. While its etiology is not well understood, genetic
factors are clearly involved. Until recently, most genetic studies in MS
have been association studies using the case-control design testing
specific candidate genes and studying only sporadic cases. The only
consistently replicated finding has been an association with the HLA-DR2
allele within the major histocompatibility complex (MHC) on chromosome 6.
Using the genetic linkage design, however, evidence for and against linkage
of the MHC to MS has been found, fostering suggestions that sporadic and
familial MS have different etiologies. Most recently, two of four genomic
screens demonstrated linkage to the MHC, although specific allelic
associations were not tested. Here, a dataset of 98 multiplex families was
studied to test for an association to the HLA-DR2 allele in familial MS and
to determine if genetic linkage to the MHC was due solely to such an
association. Three highly polymorphic markers (HLA-DR, D6S273 and TNFbeta)
in the MHC demonstrated strong genetic linkage (parametric lod scores of
4.60, 2.20 and 1.24, respectively) and a specific association with the
HLA-DR2 allele was confirmed (TDT; P < 0.001). Stratifying the results
by HLA-DR2 status showed that the linkage results were limited to families
segregating HLA-DR2 alleles. These results demonstrate that genetic linkage
to the MHC can be explained by the HLA-DR2 allelic association. They also
indicate that sporadic and familial MS share a common genetic
susceptibility. In addition, preliminary calculations suggest that the MHC
explains between 17 and 62% of the genetic etiology of MS. This
heterogeneity is also supported by the minority of families showing no
linkage or association with loci within the MHC.
相似文献
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Based on the dissection of 30 hemi-mandibles, the authors report a study of the inferior alveolar artery in its intraosseous course. On morphologic considerations they propose a classification of the collaterals into two groups: the principal collaterals destined for the teeth and the bony alveolar tissue and the secondary collaterals destined for the sheath and the nerve as well as the bony tissue around the canal. Loss of the teeth and absorption of the alveolar bone modify the caliber of the inferior alveolar arterial axis, the distribution of its collaterals and possibly its mode of termination. These facts suggest a consideration of the vascularization of the mandible in terms of four sectors. They arrive at practical conclusions that may be drawn from this study in stomatology. 相似文献
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Ph. Heitz H. Steiner F. Halter F. Egli J. P. Kapp 《Virchows Archiv : an international journal of pathology》1971,353(4):312-324
Summary Clinical, pathological and biochemical data from a twelve year old boy with hypoglycaemic attacks and hyperinsulinism are presented. A pancreatic islet cell adenoma was diagnosed by ultrasonic scanning and enucleated from the head of the pancreas. Histological study revealed a mixed cellular population consisting of A1- and B-cells. Large amounts of extravascular amyloid deposited were found between the cell strands. The tumour extract produced a prompt elevation of gastric acid secretion in the rat gastrin bio-assay. It is concluded that this islet cell tumour was a combined gastrinoma-insulinoma. The possible pathogenesis of this variety of the multiple endocrine adenoma syndrome is discussed. Monocellular-multihormonal islet cell tumours might arise from biochemically multipotent endocrine stem cells, whereas the multicellular-multihormonal type could either be a regulatory neoplasia or be derived from different neuroendocrine cells.
Zusammenfassung Bei einem übergewichtigen 12jährigen Knaben mit Hypoglykämieanfällen und erhöhtem Blutinsulinspiegel konnte durch Ultraschall ein Tumor des Pankreaskopfes dargestellt werden. Das exstirpierte Gewebe erwies sich histologisch als ein aus A1- und B-Zellen aufgebautes Inselzelladenom mit ausgedehnten extravasculären Amyloidablagerungen. Ein Extrakt aus dem Tumorgewebe bewirkte eine sofortige Zunahme der Magensäuresekretion am perfundierten Rattenmagen. Diagnose: Insulinom-Gastrinom. Monocellulärplurihormonelle Inselzelltumoren leiten sich möglicherweise von biochemisch pluripotenten Stammzellen der Langerhansschen Inseln her. Pluricellulär-plurihormonelle Adenome sind hingegen eher als Regulationsgeschwülste aufzufassen, könnten aber auch von verschiedenen neuroendokrinen Zellen abstammen.相似文献
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