全文获取类型
收费全文 | 143094篇 |
免费 | 13088篇 |
国内免费 | 9653篇 |
专业分类
耳鼻咽喉 | 1039篇 |
儿科学 | 1672篇 |
妇产科学 | 1638篇 |
基础医学 | 15109篇 |
口腔科学 | 3136篇 |
临床医学 | 17638篇 |
内科学 | 19547篇 |
皮肤病学 | 1649篇 |
神经病学 | 6703篇 |
特种医学 | 5734篇 |
外国民族医学 | 52篇 |
外科学 | 15362篇 |
综合类 | 27456篇 |
现状与发展 | 28篇 |
一般理论 | 20篇 |
预防医学 | 10972篇 |
眼科学 | 3210篇 |
药学 | 15375篇 |
146篇 | |
中国医学 | 8598篇 |
肿瘤学 | 10751篇 |
出版年
2024年 | 547篇 |
2023年 | 2022篇 |
2022年 | 5012篇 |
2021年 | 6626篇 |
2020年 | 5305篇 |
2019年 | 4192篇 |
2018年 | 4563篇 |
2017年 | 4333篇 |
2016年 | 3904篇 |
2015年 | 6275篇 |
2014年 | 7934篇 |
2013年 | 7953篇 |
2012年 | 11657篇 |
2011年 | 12324篇 |
2010年 | 8960篇 |
2009年 | 7591篇 |
2008年 | 8825篇 |
2007年 | 8399篇 |
2006年 | 7906篇 |
2005年 | 7091篇 |
2004年 | 5355篇 |
2003年 | 4900篇 |
2002年 | 4198篇 |
2001年 | 3183篇 |
2000年 | 2961篇 |
1999年 | 2665篇 |
1998年 | 1648篇 |
1997年 | 1632篇 |
1996年 | 1203篇 |
1995年 | 1143篇 |
1994年 | 969篇 |
1993年 | 595篇 |
1992年 | 648篇 |
1991年 | 591篇 |
1990年 | 489篇 |
1989年 | 426篇 |
1988年 | 345篇 |
1987年 | 331篇 |
1986年 | 261篇 |
1985年 | 191篇 |
1984年 | 131篇 |
1983年 | 89篇 |
1982年 | 71篇 |
1981年 | 52篇 |
1980年 | 37篇 |
1979年 | 50篇 |
1974年 | 21篇 |
1973年 | 22篇 |
1972年 | 20篇 |
1966年 | 19篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
高血压病是我国发病率较高的疾病之一,西医治疗以长期服用降压药物为主要治疗方式,但常因依从性差的原因导致血压控制不佳,而用中医辨证治疗对于首次发现高血压的患者,可明显有效地降低高血压的发病率。高血压病在中医学中属"眩晕",在临床中常常会用半夏白术天麻汤来治疗眩晕,本文通过跟师医案及临床收集介绍半夏白术天麻汤治疗高血压眩晕临证方药的运用。 相似文献
2.
Xiaoyan Lu Isabelle R. Miousse Sandra V. Pirela Jodene K. Moore Stepan Melnyk 《Nanotoxicology》2016,10(5):629-639
Evidence continues to grow on potential environmental health hazards associated with engineered nanomaterials (ENMs). While the geno- and cytotoxic effects of ENMs have been investigated, their potential to target the epigenome remains largely unknown. The aim of this study is two-fold: 1) determining whether or not industry relevant ENMs can affect the epigenome in vivo and 2) validating a recently developed in vitro epigenetic screening platform for inhaled ENMs. Laser printer-emitted engineered nanoparticles (PEPs) released from nano-enabled toners during consumer use and copper oxide (CuO) were chosen since these particles induced significant epigenetic changes in a recent in vitro companion study. In this study, the epigenetic alterations in lung tissue, alveolar macrophages and peripheral blood from intratracheally instilled mice were evaluated. The methylation of global DNA and transposable elements (TEs), the expression of the DNA methylation machinery and TEs, in addition to general toxicological effects in the lung were assessed. CuO exhibited higher cell-damaging potential to the lung, while PEPs showed a greater ability to target the epigenome. Alterations in the methylation status of global DNA and TEs, and expression of TEs and DNA machinery in mouse lung were observed after exposure to CuO and PEPs. Additionally, epigenetic changes were detected in the peripheral blood after PEPs exposure. Altogether, CuO and PEPs can induce epigenetic alterations in a mouse experimental model, which in turn confirms that the recently developed in vitro epigenetic platform using macrophage and epithelial cell lines can be successfully utilized in the epigenetic screening of ENMs. 相似文献
3.
4.
5.
目的观察妇科腹腔镜手术围术期碳水化合物口服疗法和传统禁饮食方案两种不同的临床处理措施对于术后胰岛素抵抗(IR)的影响。
方法选取2018年2月至8月入住徐州医科大学附属医院妇科,行腹腔镜下全子宫切除手术的非糖尿病患者共98例,将采用围术期碳水化合物口服疗法者作为观察组(50例),采用传统禁饮食方案者作为对照组(48例)。检测所有病例的术前、术后第1天及第3天的空腹血糖(FPG)及空腹胰岛素(FINS),并利用稳态模式评估法计算稳态模型胰岛素抵抗指数(HOME-IR)。对于观察组与对照组患者术前、术后第1天和术后第3天的FPG、FINS和HOME-IR等指标,组间比较采用独立样本t检验。两组患者术后腹胀、术后24 h通气、术后发热的发生情况的比较采用确切概率法检验。
结果观察组与对照组比较,术前和术后第1天FPG差异无统计学意义(P均>0.05),术后第3天FPG明显降低[(4.34±0.59)mmol/L vs (4.96±0.64)mmol/L],差异有统计学意义(t=-4.96,P=0.002)。观察组与对照组比较,术前和术后第1天FINS差异无统计学意义(P均>0.05),术后第3天FINS明显降低[(45.39±13.55)mIU/L vs (51.18±9.34) mIU/L],差异有统计学意义(t=-2.46,P=0.033)。观察组与对照组比较,术前HOME-IR差异无统计学意义(P>0.05),术后第1天和术后第3天HOME-IR明显降低[(13.08±4.80)vs (15.03±4.11);(9.37±3.65)vs (11.30±2.55)],差异有统计学意义(t=-0.69,P=0.042;t=-3.99,P=0.033)。两组患者术后其他观察指标比较,观察组术后24 h通气率与对照组比较明显增高(76.0% vs 64.6%),差异有统计学意义(P=0.045)。两组患者在术后腹胀、术后发热的发生率方面差异无统计学意义(P均>0.05)。两组患者均未发生术中误吸。
结论妇科腹腔镜手术围术期应用碳水化合物口服疗法较传统禁饮食方案,能有效减轻术后IR程度,促进术后康复进程,且不增加围术期并发症的发生率。 相似文献
6.
7.
目的:探讨胸膝卧位矫正枕位异常的可行性。方法:将单胎初产临产的枕位异常的产妇186例,随机分成两组,入选者均无绝对头盆不称、胎儿窘迫、严重妊娠并发症及合并症,其中96例为观察组采取胸膝卧位矫正枕位,另90例为对照组按常规处理。结果:观察组产程明显缩短,阴道分娩率明显增加,而胎儿窘迫及新生儿窒息率明显降低,两组比较有统计学意义。结论:胸膝卧位在产程中矫正枕位异常是一种切实可行的方法 相似文献
8.
9.
Stress Testing Versus CT Angiography in Patients With Diabetes and Suspected Coronary Artery Disease
Abhinav Sharma Adrian Coles Nishant K. Sekaran Neha J. Pagidipati Michael T. Lu Daniel B. Mark Kerry L. Lee Hussein R. Al-Khalidi Udo Hoffmann Pamela S. Douglas 《Journal of the American College of Cardiology》2019,73(8):893-902
Background
The optimal noninvasive test (NIT) for patients with diabetes and stable symptoms of coronary artery disease (CAD) is unknown.Objectives
The purpose of this study was to assess whether a diagnostic strategy based on coronary computed tomographic angiography (CTA) is superior to functional stress testing in reducing adverse cardiovascular (CV) outcomes (CV death or myocardial infarction [MI]) among symptomatic patients with diabetes.Methods
PROMISE (Prospective Multicenter Imaging Study for Evaluation of Chest Pain) was a randomized trial evaluating an initial strategy of CTA versus functional testing in stable outpatients with symptoms suggestive of CAD. The study compared CV outcomes in patients with diabetes (n = 1,908 [21%]) and without diabetes (n = 7,058 [79%]) based on their randomization to CTA or functional testing.Results
Patients with diabetes (vs. without) were similar in age (median 61 years vs. 60 years) and sex (female 54% vs. 52%) but had a greater burden of CV comorbidities. Patients with diabetes who underwent CTA had a lower risk of CV death/MI compared with functional stress testing (CTA: 1.1% [10 of 936] vs. stress testing: 2.6% [25 of 972]; adjusted hazard ratio: 0.38; 95% confidence interval: 0.18 to 0.79; p = 0.01). There was no significant difference in nondiabetic patients (CTA: 1.4% [50 of 3,564] vs. stress testing: 1.3% [45 of 3,494]; adjusted hazard ratio: 1.03; 95% confidence interval: 0.69 to 1.54; p = 0.887; interaction term for diabetes p value = 0.02).Conclusions
In diabetic patients presenting with stable chest pain, a CTA strategy resulted in fewer adverse CV outcomes than a functional testing strategy. CTA may be considered as the initial diagnostic strategy in this subgroup. (PROspective Multicenter Imaging Study for Evaluation of Chest Pain [PROMISE]; NCT01174550) 相似文献10.