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KARL HEINZ BRISCH DORIS BECHINGER SUZANNE BETZLER HILDE HEINEMANN 《Attachment & human development》2013,15(2):120-135
The birth of a very small preterm infant ( 1500 grams) can be a traumatizing experience for many parents. A developmental risk model is presented that is the background to an early attachment-oriented preventive psychotherapeutic intervention. This comprehensive parent-centered intervention program is composed of supportive group psychotherapy, attachment-oriented focal individual psychotherapy, a home visit and video-based sensitivity training. The intervention aims at improving parental coping, the process of attachment and parent-infant interaction. In a prospective longitudinal design mothers were randomly assigned to a control (N = 44) and an intervention group (N = 43) after preterm delivery. Results show that the percentage of secure (control vs. intervention group: 77.8% vs. 59.4%) and insecure (control vs. intervention group: 8.3% vs. 31.3% avoidant, 13.9% vs. 9.4% ambivalent) attachment quality in high-risk preterm infants is comparable to results from studies with term infants. There was no significant statistical difference in terms of quality of attachment of the preterm infants between the control group and the intervention group. However, only in the control group, impaired neurological development corresponded significantly with an insecure quality of attachment, but not in the intervention group, although there were significantly more neurologically impaired infants in the intervention group. This result is discussed as an effect of the intervention program. 相似文献
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BØRGE SIVERTSEN SIMON ØVERLAND STÅLE PALLESEN BJØRN BJORVATN INGER HILDE NORDHUS JOHN GUNNAR MÆLAND ARNSTEIN MYKLETUN 《Journal of sleep research》2009,18(1):122-128
Both insomnia and sleep duration have previously been linked with a range of adverse outcomes, but no studies have explored their relative effect on subsequent work disability. The aim of the present study was to investigate the contribution of insomnia versus sleep duration to later long-term work disability. Using a historical cohort design with 4-year follow-up, data on insomnia, sleep duration and potential confounders were gathered from 6599 working persons (40–45 years). The outcome was award of disability pension, as registered in the National Insurance Administration. After controlling for baseline exposure to disability and sick leave, insomnia was a strong predictor of permanent work disability [odds ratio (OR) = 4.56], and this effect remained significant after controlling for sleep duration, as well as for other possible confounders (OR = 1.88). Short sleep duration was not significantly associated with subsequent work disability, while long sleep duration (>8.5 h) did predict work disability (OR = 2.96), also in the fully adjusted model (OR = 2.14).The present study demonstrates that both insomnia and long sleep duration are strong and independent risk factors for subsequent work disability. 相似文献
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LINDA STRAND ANDREW JENKINS NILS GRUDE ANNE‐GRY ALLUM HILDE‐CHRISTINE MYKLAND FOUROUGH L. NOWROUZIAN BJøRN‐ERIK KRISTIANSEN 《APMIS : acta pathologica, microbiologica, et immunologica Scandinavica》2010,118(8):571-577
Strand L, Jenkins A, Grude N, Allum A‐G, Mykland H‐C, Nowrouzian FL, Kristiansen B‐E. Emergence of fluoroquinolone‐resistant clonal group A: clonal analysis of Norwegian and Russian E. coli isolates. APMIS 2010; 118: 571–77. We describe a study of urinary tract and intestinal isolates of Escherichia coli from Norway and Russia using automated ribotyping, single nucleotide polymorphism analysis for clonal group A (CgA) supplemented with phylogrouping, virulence gene profiling and resistance profiling. CgA comprised 19% of the Norwegian UTI isolates from 2001. Two highly multiresistant fluoroquinolone‐resistant CgA isolates were found. Ribotypes clustered into four major and six minor groups (ribogroups). Fluoroquinolone‐resistant isolates and phylogroups A and B1 were associated with ribogroup RA. Ribogroup RB predominated among Russian UTI isolates and was predominantly phylogroup A and depleted in P‐fimbriae. Ribogroup RC predominated among Norwegian UTI isolates and was rich in virulence factors (S‐fimbriae, haemagglutinin and haemolysin) and predominantly phylogroup B2 and D. Ribogroup RG was associated with CgA and predominantly phylogroup D. Ribogroups RD, RE and RF had too few members for statistical analysis. The correlation between ribotype and phylogenetic group was not as strong as reported in other studies. 相似文献
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HILDE DEMUYNCK MICHEL DELFORGE GREGOR VERHOEF PIERRE ZACHEE PETER VANDENBERGHE MARC BOOGAERTS 《British journal of haematology》1995,90(2):384-392
Summary. Patients suffering from high-risk multiple myeloma (MM) were randomized to receive single high-dose cyclophosphamide followed by either rhGM-CSF or rhG-CSF in order to harvest circulating peripheral blood progenitor cells. The safety of the procedure, the mobilization kinetics, the relative efficacy of rhGM-CSF and rhG-CSF to mobilize progenitor cells and their relative toxicity were studied. Special attention was paid to the antigenic profile of CD34+ progenitor cells.
Group I patients (n=ll) were treated with cyclophosphamide 4 g/m2 i.v. followed by rhGM-CSF at 10 /ig/kg/d by subcutaneous administration. Group II (n=ll) patients received rhG-CSF s.c. at 10/zg/kg/d after the same dose cyclophosphamide. Both mobilization regimens appeared to be equally effective. No significant differences in absolute numbers of circulating progenitors, determined by CD34 expression or in yields of MNC, CFU-GM, BFU-E and CD34 subsets were observed. rhGM-CSF administration resulted however in delayed haemopoietic recovery and an increased complication rate.
We conclude that rhG-CSF may be preferred because of its markedly lower toxicity and lower in-hospital costs. 相似文献
Group I patients (n=ll) were treated with cyclophosphamide 4 g/m
We conclude that rhG-CSF may be preferred because of its markedly lower toxicity and lower in-hospital costs. 相似文献
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HILDE VAN WAELVELDE ANN OOSTRA GRIET DEWITTE CHRISTINE VAN DEN BROECK MARIAN J JONGMANS 《Developmental medicine and child neurology》2010,52(8):e174-e178
Aim The aim of this study was to investigate the stability of motor problems in a clinically referred sample of children with, or at risk of, autism spectrum disorders (ASDs), attention‐deficit–hyperactivity disorder (ADHD), and/or developmental coordination disorder (DCD). Method Participants were 49 children (39 males, 10 females; mean age 5y 6mo, SD 10mo) with various developmental problems, a Movement Assessment Battery for Children (M‐ABC) score on or below the 15th centile, and an IQ of 70 or more. Sixteen children were at risk of developing ADHD, 15 children had a diagnosis of, or were at risk of developing ASD, and 18 children had neither diagnosis. Children were reassessed 2 to 3 years later. Results At follow‐up (mean age 7y 11mo; SD 1y), the mean M‐ABC score was significantly increased, and in 22 children was no longer below the 15th centile. A general linear model to compare the difference in M‐ABC scores in the three groups of children demonstrated a significant difference between groups (p=0.013), with the age at the initial assessment as a significant covariate (p=0.052). The group of children with or at risk of ASD showed less improvement in motor performance. Interpretation Motor problems among preschool age children are not always stable, but appear to be so in most children with ASDs. 相似文献
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LIV SKARTVEIT ANNE BJÖRG TVEIT IVAR A. MJÖR HILDE TOMBRE AAS 《European journal of oral sciences》1986,94(1):72-76
The aim of this study was to compare the marginal breakdown as a measure of clinical behavior of fillings made with two conventional amalgam alloys, one of which contained 1% stannous fluoride. Children requiring class II restorations in both mandibular molars received conventional amalgam (New True Dentalloy (R)) in one molar and a fluoride-containing amalgam (Fluor Alloy (R)) in the other. Impressions of the filled teeth were taken just after polishing and at 1-yr intervals up to a 2-yr period. Plastic models were made and evaluated under a stereomicroscope. The results showed that the fluoride-containing amalgam presented slightly better margins than the conventional amalgam after 2 yr. 相似文献
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HILDE LINDEMANN 《The Hastings Center report》2009,39(5):39-45
American bioethicists lack the theoretical resources to work in cross‐cultural settings. All we have are two approaches to ethics—principles vs. narratives—that are mostly at odds, and neither of which is up to the job. If moral principles are too abstract to be useful, and if stories cannot provide moral authority, then where do we find our moral norms? 相似文献
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