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排序方式: 共有195条查询结果,搜索用时 15 毫秒
1.
Abstract— Biomedical determinants of dental caries have been more extensively investigated than psychosocial factors and their impact on caries prevalence and incidence seems to be greater. However, a majority of these investigations relate to children and adolescents. An implementation of social and psychologic variables may be more relevant regarding dental caries in adults. In addition, a multidisciplinary approach might improve our understanding of dental caries as a multifactorial disease and bridge the gap between a biomedical concept and a more holistic approach to dental health. 相似文献
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A Decrease in Pulmonary Vein Diameter After Radiofrequency Ablation Predicts the Development of Severe Stenosis 总被引:3,自引:0,他引:3
ALEXANDER BERKOWITSCH THOMAS NEUMANN OKAN EKINCI HARALD GREISS THORSTEN DILL KLAUS KURZIDIM MALTE KUNISS HANS J. SCHNEIDER HEINZ F. PITSCHNER 《Pacing and clinical electrophysiology : PACE》2005,28(S1):S83-S85
A decrease in ostial pulmonary vein (PV) diameter was observed in patients on the day after radiofrequency ablation of atrial fibrillation (AF). This study examined whether a relative reduction in PV diameter on day 1 (RRPVD1) after the procedure predicts the late development of severe PV stenosis (PVS). The study included 104 consecutive patients (mean age = 55 years, range 46–61, 34 women) with drug refractory AF. Pulmonary vein diameter was measured using MR angiography (MRA) on the day before and on day 1 after the ablation procedure. The MRA was repeated every 3 months after the procedure. Severe PVS was defined as a >70% diameter reduction from the initial ostial diameter. The cut-off of RRPVD1 was prespecified as 25% decrease in initial diameter. The data are presented as medians and interquartile range. A total of 357 PV were treated. The RRPVD1 was 0.0% (0.0–11.1%). Severe PVS was found in 18 PV during a follow-up of 12 months (range 6–13). The log-rank analysis confirmed a strong association between a RRPVD1 ≥25% and the development of PVS (hazard ratio: 7.1; 95% confidence interval 3.8–13.5, P < 0.0001). By multivariate Cox regression model, after adjustment of procedure variables, RRPVD1 was the strongest predictor of development of severe PVS. RRPVD1 ≥25% was a strong independent predictor of development of severe PVS. 相似文献
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RUNJAN CHETTY KAREN PULFORD MARGARET JONES DANIELE MATHIEU-MAHUL PAULINE CLOSE SONAY HUSSEIN GORM PALLESEN ELIZABETH RALFKIAER HARALD STEIN KEVIN GATTER DAVID MASON 《The Journal of pathology》1996,178(3):311-315
Fifty formalin fixed, paraffin-embedded cases of T-acute lymphoblastic leukaemia (T-ALL) from 12 bone marrow trephines and 38 lymph nodes were stained with a new monoclonal antibody, 2TL 242, raised against recombinant TAL1 protein. The antibody recognizes TAL-1 polypeptides of molecular weight 39 and 41 kD (full length). In addition, a variety of other leukaemias and lymphomas were also stained with 2TL 242. Twenty-four of the 50 cases of T-ALL showed nuclear positivity, ranging from 10 to 90 per cent of leukaemic cells. A positive staining reaction was nuclear and stippled in pattern. Nuclear staining was not seen in any other type of leukaemia or lymphoma. Five cases of follicular lymphoma showed diffuse cytoplasmic staining of variable intensity. Although some background staining is obtained with this antibody, positive nuclear staining is easily distinguishable. This monoclonal antibody has a potential role in primary diagnosis and in the detection of minimal residual disease in T-ALL. 相似文献
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DAVID GOBETS HELEEN BECKERMAN VINCENT de GROOT MIRIAM H VAN DOORN‐LOOGMAN JULES G BECHER 《Developmental medicine and child neurology》2010,52(6):517-528
Aim To give an overview of indications for the use of botulinum toxin A (BoNT‐A) treatment for children with obstetric brachial plexus injury (OBPI), and to present the best available evidence of the effectiveness of this treatment. Method Searches were performed in Cinahl, Cochrane Library, Embase, PubMed, and Web of Science, using the keywords ‘botulinum’ and ‘plexus’, to identify articles reporting on the use of BoNT‐A as a treatment for children with OBPI. Studies found through the references of related articles were also selected. Results Ten full‐text papers and six congress abstracts were included, involving 343 children. Four groups of indications could be identified: internal rotation/adduction contracture of the shoulder, limited active elbow flexion, limited active elbow extension, and pronation contracture of the lower arm. Overall, positive results were reported for all except the indication for limited active elbow extension. However, only one study was comparative in nature; all others were classified as having a low level of evidence. There was a large variation in outcome measures. Interpretation To provide better evidence for the already partly promising results of BoNT‐A treatment for children with OBPI, multicentre randomized controlled trials are needed. 相似文献
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abstract – Groups of white albino rats were used in this study. Serial sections were prepared of the hard and soft palate, tongue, cheek, gingiva, cornea and ear, and were stained with hematoxylin and eosin. Mitotic counts in tongue epithelium of nine groups of rats which received various colchicine dosages (0 to 3 mg/kg body weight) and were sacrificed 3½ h later showed that 1 mg colchicine per kg body weight is the optimal dosage for studying the mitotic activity in rat oral epithelium. Mitotic counts in six other groups of rats sacrificed at different times (0 to 50 min) after the administration of colchicine indicated that the colchicine takes effect 25–30 min after the injection. The pattern of diurnal variation in mitotic activity was determined in the ear and various oral epithelia using eight groups of colchicinized rats. A fairly high correlation was found between the daily mitotic rates and the mitotic rates obtained during the maximum mitotic activity. There was a low correlation between the daily mitotic rates and turnover times indicating that calculations of turnover time may fail to express the mitotic activity of the epithelium. Mitotic counts for various sites of the hard palate, tongue and cheek in seven rats indicated that the mitotic activity may vary from one region to another within the individual tissue. 相似文献
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HARALD VIK-MO 《Journal of internal medicine》1986,219(1):3-10
ABSTRACT. The value of M-mode echocardiography in assessment of left ventricular (LV) function in patients with aortic regurgitation due to aortic valve endocarditis (AVE) was studied in 12 consecutive patients and compared with the findings in 30 patients with chronic aortic regurgitation (CAR). Patients with AVE had markedly increased LV end-diastolic and end-systolic diameters, whereas fractional shortening was normal. A linear correlation was found between the LV ejection fractions calculated by echocardiography and angiography, but echocardiography markedly overestimated the ejection fractions. There was a close linear correlation between the prematurity of mitral valve closure (MVC) and LV end-diastolic pressure. Patients with CAR had lower end-diastolic pressure, similarly increased LV internal diameters and none had premature MVC. Thus, M-mode echocardiography can identify patients with premature MVC and high LV filling pressure. However, echocardiographic LV function indices based on measurement of internal dimensions overestimate the LV function and these data should be interpreted with caution. 相似文献