全文获取类型
收费全文 | 3456篇 |
免费 | 342篇 |
国内免费 | 53篇 |
专业分类
耳鼻咽喉 | 10篇 |
儿科学 | 235篇 |
妇产科学 | 55篇 |
基础医学 | 448篇 |
口腔科学 | 136篇 |
临床医学 | 407篇 |
内科学 | 883篇 |
皮肤病学 | 42篇 |
神经病学 | 223篇 |
特种医学 | 191篇 |
外科学 | 333篇 |
综合类 | 34篇 |
一般理论 | 1篇 |
预防医学 | 230篇 |
眼科学 | 20篇 |
药学 | 342篇 |
1篇 | |
中国医学 | 11篇 |
肿瘤学 | 249篇 |
出版年
2023年 | 17篇 |
2021年 | 27篇 |
2020年 | 35篇 |
2019年 | 47篇 |
2018年 | 69篇 |
2017年 | 71篇 |
2016年 | 67篇 |
2015年 | 74篇 |
2014年 | 108篇 |
2013年 | 142篇 |
2012年 | 126篇 |
2011年 | 146篇 |
2010年 | 111篇 |
2009年 | 142篇 |
2008年 | 150篇 |
2007年 | 157篇 |
2006年 | 123篇 |
2005年 | 162篇 |
2004年 | 128篇 |
2003年 | 116篇 |
2002年 | 97篇 |
2001年 | 127篇 |
2000年 | 111篇 |
1999年 | 90篇 |
1998年 | 110篇 |
1997年 | 110篇 |
1996年 | 83篇 |
1995年 | 83篇 |
1994年 | 69篇 |
1993年 | 66篇 |
1992年 | 70篇 |
1991年 | 64篇 |
1990年 | 73篇 |
1989年 | 74篇 |
1988年 | 66篇 |
1987年 | 62篇 |
1986年 | 59篇 |
1985年 | 58篇 |
1984年 | 39篇 |
1983年 | 40篇 |
1982年 | 30篇 |
1981年 | 40篇 |
1980年 | 24篇 |
1979年 | 21篇 |
1978年 | 22篇 |
1977年 | 22篇 |
1976年 | 15篇 |
1975年 | 14篇 |
1973年 | 14篇 |
1970年 | 12篇 |
排序方式: 共有3851条查询结果,搜索用时 9 毫秒
1.
2.
Emmi Helle Aldo Córdova-Palomera Tiina Ojala Priyanka Saha Praneetha Potiny Stefan Gustafsson Erik Ingelsson Michael Bamshad Deborah Nickerson Jessica X. Chong University of Washington Center for Mendelian Genomics Euan Ashley James R. Priest 《Genetic epidemiology》2019,43(2):215-226
Loss of function variants in NOTCH1 cause left ventricular outflow tract obstructive defects (LVOTO). However, the risk conferred by rare and noncoding variants in NOTCH1 for LVOTO remains largely uncharacterized. In a cohort of 49 families affected by hypoplastic left heart syndrome, a severe form of LVOTO, we discovered predicted loss of function NOTCH1 variants in 6% of individuals. Rare or low-frequency missense variants were found in 16% of families. To make a quantitative estimate of the genetic risk posed by variants in NOTCH1 for LVOTO, we studied associations of 400 coding and noncoding variants in NOTCH1 in 1,085 cases and 332,788 controls from the UK Biobank. Two rare intronic variants in strong linkage disequilibrium displayed significant association with risk for LVOTO amongst European-ancestry individuals. This result was replicated in an independent analysis of 210 cases and 68,762 controls of non-European and mixed ancestry. In conclusion, carrying rare predicted loss of function variants in NOTCH1 confer significant risk for LVOTO. In addition, the two intronic variants seem to be associated with an increased risk for these defects. Our approach demonstrates the utility of population-based data sets in quantifying the specific risk of individual variants for disease-related phenotypes. 相似文献
3.
4.
5.
6.
CM Reid M. Nelson P. Beckinsale P. Ryan LMH Wing LJ Beilin MA Brown GLR Jennings CI Johnston J. Marley JJ McNeil TO Morgan J. Shaw ID Steven MJ West 《Clinical and experimental pharmacology & physiology》1997,24(5):370-373
1. The present study aimed to determine the feasibility of conducting a 5 year cardiovascular outcome trial of the treatment of 6000 elderly hypertensive patients in Australian general practices. 2. General practitioners (GPs) were invited to participate by mail and personal follow-up. Patient records were reviewed to identify subjects for a blood pressure (BP) screening programme. Blood pressure was measured on three occasions and eligible subjects were included if the average BP was 160 mmHg systolic or 90 mmHg diastolic if systolic BP was 140 mmHg. 3. Seven hundred and forty-one GPs were approached and 89 were enrolled in the study (12% of mail invites and 75% of those receiving a personal contact). In 16 practices where screening was completed, 82 000 records were reviewed to identify 4% patients eligible for screening. Twenty-two per cent of eligible subjects attended screening. Of 1938 subjects screened, 180 (9%) had BP 5=160/90 mmHg. Forty-seven percent of subjects (n = 916) were receiving antihypertensive therapy and 184 (20%) were withdrawn from therapy. One hundred and sixteen (63%) of these subjects had BP return to study entry levels within 6 weeks. Fifty-seven newly diagnosed and 81 previously treated subjects were randomized (7% of the screened population). 4. Based on the high participation rate of GPs, the response rate of patients to attend a BP screening programme and the 7% randomization to screening ratio for entry into the study, the ANBP2 pilot study has demonstrated that it is feasible to recruit subjects from Australian general practices to a cardiovascular outcome trial. 相似文献
7.
Complications following combined transrectal aspiration and core biopsy of the prostate 总被引:2,自引:0,他引:2
O Gustafsson U Norming C R Nyman M Ohstr?m 《Scandinavian journal of urology and nephrology》1990,24(4):249-251
Ultrasound guided biopsy of the prostate with fine needle (22G) as well as trucut needle (18G) was performed in 145 patients with a suspicion of prostate cancer. After three weeks all patients were interviewed about complications associated with the biopsy. Hematuria and/or hemospermia occurred in 2/3 of the patients. None of the hemorrhages was severe and all ceased spontaneously. E. coli infection of the urinary tract occurred in 9 cases (6.2%). Five of the infections caused high fever and necessitated hospital care with parenteral antibiotics for 1 to 8 days. The patients with infection had no signs of immunological defects by which they might have been identified before the biopsy. As a consequence of these observations we now use prophylactic antibiotics when core biopsy of the prostate is performed transrectally. 相似文献
8.
The effect of cooking time on mutagenic activity in crust, pan residue and smoke from pan-broiled pork patties was studied in the Ames Salmonella mutagenicity test system. The effect on mutagenicity of reheating the cooked patties and of keeping them warm was also studied. The meat was broiled at 200 degrees C for various times between 2 and 10 min. Broiled meat was reheated up to 5 times at 200 degrees C, each time to a centre temperature of 70 degrees C. Reheating was also performed in a microwave oven for 2 min and in an electric oven at 200 degrees C for 10 min. In addition, broiled patties were kept warm at 60 degrees C in an incubator for up to 9 hr. The mutagenic activity increased rapidly in all fractions except the volatile phase over the first 6 min of cooking, after which time only a slight increase was seen. At cooking times below 4 min no mutagenic activity was detected in the smoke. Reheating or keeping the meat warm for up to 9 hr had very little effect on the mutagenic activity of the meat. Reversed-phase high-performance liquid chromatography mutagenicity profiles of the aerosol, crust and pan-residue extracts showed no major qualitative differences in samples cooked at different times. It is concluded that during pan broiling at 200 degrees C the major part of the mutagenic activity is formed during the first 6 min of cooking. Reheating the meat or keeping it warm does not significantly affect the mutagenic activity. No major additional mutagens are formed during continued heating for up to 25 min. 相似文献
9.
LY Chow MRCPsych D Chung MRCPsych V Leung MB BS TF Leung MB ChB CM Leung MRCPsych 《International journal of clinical practice》1997,51(5):330-331
Akathisia as a side-effect of metoclopramide has received increasing attention in consultation-liaison psychiatry in recent years. A case of metoclopramide-induced akathisia resulting in a suicide attempt is reported in order to highlight the suffering of such patients and the factors that lead to misdiagnosis. 相似文献
10.