全文获取类型
收费全文 | 484篇 |
免费 | 45篇 |
国内免费 | 23篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 24篇 |
妇产科学 | 7篇 |
基础医学 | 43篇 |
口腔科学 | 9篇 |
临床医学 | 53篇 |
内科学 | 111篇 |
皮肤病学 | 65篇 |
神经病学 | 17篇 |
特种医学 | 76篇 |
外科学 | 18篇 |
综合类 | 17篇 |
预防医学 | 30篇 |
药学 | 61篇 |
肿瘤学 | 19篇 |
出版年
2023年 | 3篇 |
2022年 | 2篇 |
2021年 | 2篇 |
2020年 | 2篇 |
2019年 | 9篇 |
2018年 | 12篇 |
2017年 | 7篇 |
2016年 | 6篇 |
2015年 | 16篇 |
2014年 | 10篇 |
2013年 | 19篇 |
2012年 | 19篇 |
2011年 | 17篇 |
2010年 | 14篇 |
2009年 | 20篇 |
2008年 | 18篇 |
2007年 | 28篇 |
2006年 | 21篇 |
2005年 | 18篇 |
2004年 | 12篇 |
2003年 | 11篇 |
2002年 | 15篇 |
2001年 | 13篇 |
2000年 | 6篇 |
1999年 | 12篇 |
1998年 | 22篇 |
1997年 | 17篇 |
1996年 | 28篇 |
1995年 | 8篇 |
1994年 | 18篇 |
1993年 | 8篇 |
1992年 | 8篇 |
1991年 | 9篇 |
1990年 | 11篇 |
1989年 | 9篇 |
1988年 | 16篇 |
1987年 | 10篇 |
1986年 | 9篇 |
1985年 | 11篇 |
1984年 | 8篇 |
1983年 | 7篇 |
1982年 | 8篇 |
1981年 | 8篇 |
1980年 | 6篇 |
1979年 | 1篇 |
1978年 | 4篇 |
1977年 | 4篇 |
1976年 | 7篇 |
1975年 | 3篇 |
排序方式: 共有552条查询结果,搜索用时 15 毫秒
1.
SB Miranda† O Lupi‡ E Lucas† 《Journal of the European Academy of Dermatology and Venereology》2004,18(5):622-625
Pityriasis rosea (PR) is a relatively common disease although its aetiology has not yet been identified. It occurs worldwide and there is no racial susceptibility factor. It usually affects teenagers and young adults between 10 and 35 years of age. Typical PR is much easier to diagnose than the rare atypical forms. We report a rare case of vesicular PR in a black woman who had vesicular lesions limited to her palms and soles in addition to regular typical lesions. We devised an efficient oral erythromycin treatment for this patient. 相似文献
2.
Stent placement for benign pancreatic diseases: correlation between ERCP findings and clinical response. 总被引:1,自引:0,他引:1
D J Gulliver S Edmunds M E Baker S Paine J Baillie P B Cotton R P Rice 《AJR. American journal of roentgenology》1992,159(4):751-755
OBJECTIVE. We performed a study to determine if the appearance of the pancreatic duct on ERCP before and after placement of pancreatic duct stents correlates with the therapeutic response in patients treated for impaired pancreatic drainage. MATERIALS AND METHODS. Findings in 29 consecutive patients with a variety of benign pancreatic diseases in whom pancreatic stents were placed and subsequently removed within a 3-year period were reviewed retrospectively. Early (1-5 days) and late (1-3 months) clinical outcomes after stent placement were assessed. These findings were correlated with a blinded interpretation of ERCP findings (Cambridge criteria were used) before and after stent placement. RESULTS. ERCP findings before stent placement were normal in 10 patients. At the end of stent therapy, ERCP showed changes associated with chronic pancreatitis in all 10; five had focal narrowing at the tip of the stent. Subsequent ERCP studies in five of these 10 patients showed that ductal changes induced by stents diminished after stent removal. Of the 19 patients with abnormal findings on ERCP at the time of stent placement, ERCP at the end of stent therapy showed some improvement in seven patients, no change in eight, and deterioration in four. Changes seen on ERCP had no statistically significant correlation with clinical outcome (p = .36). CONCLUSION. Our findings show that pancreatic duct stents can induce abnormalities on ERCP indicative of chronic pancreatitis. However, diminution of these abnormalities after stent removal in some patients suggests that these changes may be due to edema rather than to fibrosis. Ductal changes seen on ERCP are not a useful guide for determining the degree of response to pancreatic stents. 相似文献
3.
4.
5.
6.
进一步研究了抗三尖杉酯碱的HL-60细胞(HR20)抗细胞凋亡的机制及该抗性和抗药性的关系。结果表明,环孢菌素A(CsA)20,10μg·ml ̄(-1)诱导HL-60细胞发生凋亡,而阻断HR20细胞于G_1期,就不能诱导细胞发生凋亡。低浓度的CsA明显增加柔红霉素在HR20细胞内的积聚,其逆转抗药性作用与阻断细胞周期运行无关。CsA10μg·ml ̄(-1)处理HR20细胞,可引起50kDa的蛋白质高度磷酸化。结果提示:环孢菌素A阻断抗三尖杉酯碱的HL-60细胞于G_1期,而诱导敏感的HL-60细胞发生凋亡,其阻断作用与抗药性无关 相似文献
7.
Human papillomavirus 16 DNA immortalizes two types of normal human epithelial cells of the uterine cervix.
下载免费PDF全文
![点击此处可从《The American journal of pathology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
K. Tsutsumi N. Belaguli S. Qi T. I. Michalak W. P. Gulliver A. Pater M. M. Pater 《The American journal of pathology》1992,140(2):255-261
Premalignant cervical lesions occur at the squamo-columnar junction and in endocervical epithelium and squamous ectocervical epithelium, in descending order of frequency. However, previously only ectocervical cells have been clearly shown to be immortalized in vitro by the oncogenic human papillomaviruses (HPVs). This report describes the immortalization of normal human ecto- and endocervical epithelial cells by the intact HPV 16 genome. Ectocervical epithelial cells (HEC) became immortalized (HEC-16) without crisis while endocervical cells (HEN) were immortalized (HEN-16) after undergoing crisis. HEN-16 and HEC-16 contained integrated HPV 16 DNA, expressed E6 and E7 mRNA, and were aneuploid and nontumorigenic. They also expressed cytokeratins in a pattern similar to their distinct normal parental cells. These results suggest that both squamous and simple epithelial cells of uterine cervix are targets for immortalization by HPV 16. 相似文献
8.
Needle biopsy of renal allografts: comparison of two techniques 总被引:2,自引:0,他引:2
Bogan ML; Kopecky KK; Kraft JL; Holladay AO; Filo RS; Leapman SB; Thomalla JV 《Radiology》1990,174(1):273-275
Two techniques for renal allograft biopsy were retrospectively evaluated to compare relative safety and efficacy. After ultrasound (US) localization of the kidney and biopsy with a hand-held 14-gauge cutting needle, an adequate specimen was obtained in 74 of 77 cases (96%). Major complications occurred in six of these 77 cases (8%). One hundred four biopsies were performed by using a smaller 18-gauge cutting needle with a spring-loaded biopsy "gun" and real-time US guidance. With this newer technique, specimens adequate for diagnosis were obtained in 99 biopsies (95%). There was a single major complication with this technique (1%). The 18-gauge needle with real-time US guidance yields comparably adequate specimens with a lower frequency of complications. 相似文献
9.
分娩期连续电子胎心监护用于胎儿评估 总被引:1,自引:0,他引:1
1背景 在美国,每4例孕妇中有3例在产群中及分娩时使用电子胎儿监护(EFM)(NCHS1993)。1989年,美国妇产科学院(ACOG1989)发表了一项声明,对于低危妊娠既可使用EFM,也可使用间断性胎心听诊;但是,美国预防保健委员会(USPSTF1989)和加拿大的定期健康检查委员会(CTFPHE1994)对高危妊娠仍保留使用EFM。尽管有人对EFM的效果和安全性表示担忧(Thacker 1987:Thacker 1995), 相似文献
10.
SB Grover N Midha M Gupta U Sharma VH Talib 《Journal of Medical Imaging and Radiation Oncology》2005,49(2):175-178
The clinical manifestations of chronic disseminated histoplasmosis are non-specific and resemble those of other chronic infections and malignancies. We report the radiographic, sonographic and contrast-enhanced CT appearances of histoplasmosis in an adult male with non-insulin dependent diabetes mellitus, who was HIV negative and presented with weight loss and pyrexia. Imaging studies simulated tuberculosis with mediastinal lymphadenopathy, bilateral fibrotic lung lesions, hepatomegaly and bilateral hypoattenuating adrenal enlargement, without clinical or laboratory evidence of hypoadrenalism. Computed tomography-guided fine-needle aspiration biopsy of adrenal glands revealed Histoplasma capsulatum. We report our experience to increase awareness of the imaging spectrum of disseminated histoplasmosis and its similarity to tuberculosis as, with increasing incidence of AIDS, the chances of these infections are likely to increase. Moreover, awareness of this entity is important because it is known that untreated disseminated histoplasmosis is fatal. 相似文献