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排序方式: 共有259条查询结果,搜索用时 15 毫秒
1.
Bojan Pajic Grigoris Pallas Gerding Heinrich Matthias Böhnke 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2006,244(1):22-27
Purpose It was the aim of this study to investigate the efficacy, longevity, and safety of a new ab interno intervention for the treatment
of primary open-angle glaucoma (POAG).
Methods The previously described method of radiofrequency-mediated “sclerothalamotomy ab interno” was applied in 53 eyes of consecutive
patients with POAG between April 2002 and July 2002. Average preoperative intraocular pressure (IOP) was 25.6±2.3 mmHg (range
18–48 mmHg). Sclerothalamotomies were carried out with a custom-made high-frequency dissection 19 G probe (tip 0.3×1 mm) applying
bipolar current with a frequency of 500 kHz (tip temperature 130°C).
Results After a follow-up period of 24 months, the average IOP was 15.0±1.6 mmHg (range 11–20 mmHg) (p<0.005). The average number of topical agents was 2.6±1.0 (range 1–5) preoperatively. Twenty-four months after surgery such
agents were used in only five (9.6%) eyes and the average was 0.21±0.53 (range 0–2). Transient IOP elevation was observed
in 12 of 53 eyes (22.6%) postoperatively. In all cases elevated IOP could efficiently be controlled with topical medication.
In general, IOP dropped continuously over the course of the 6 months following surgery and then remained constant.
Conclusions This study indicates that sclerothalamotomy ab interno is a safe and efficient surgical method for the treatment of POAG.
Long-term results clearly demonstrate the longevity of IOP reduction. 相似文献
2.
O Georgiadou I Vogiatzis G Stratakos A Koutsoukou S Golemati A Aliverti C Roussos S Zakynthinos 《The European respiratory journal》2007,29(2):284-291
In order to investigate underlying mechanisms, the present authors studied the effect of pulmonary rehabilitation on the regulation of total chest wall and compartmental (ribcage, abdominal) volumes during exercise in patients with chronic obstructive pulmonary disease. In total, 20 patients (forced expiratory volume in one second, mean +/- SEM 39 +/- 3% predicted) undertook high-intensity exercise 3 days x week(-1) for 12 weeks. Before and after rehabilitation, the changes in chest wall (cw) volumes at the end of expiration (EEV) and inspiration (EIV) were computed by optoelectronic plethysmography during incremental exercise to the limit of tolerance (W(peak)). Rehabilitation significantly improved W(peak) (57+/-7 versus 47+/-5 W). In the post-rehabilitation period and at identical work rates, significant reductions were observed in minute ventilation (35.1+/-2.7 versus 38.4+/-2.7 L x min(-1)), breathing frequency (26+/-1 versus 29+/-1 breaths x min(-1)) and EEV(cw) and EIV(cw) (by 182+/-79 and 136+/-37 mL, respectively). Inspiratory reserve volume was significantly increased (by 148+/-70 mL). Volume reductions were attributed to significant changes in abdominal EEV and EIV (by 163+/-59 and 125+/-27 mL, respectively). The improvement in W(peak) was similar in patients who progressively hyperinflated during exercise and those who did not (24 and 26%, respectively). In conclusion, pulmonary rehabilitation lowers chest wall volumes during exercise by decreasing the abdominal volumes. The improvement in exercise capacity following rehabilitation is independent of the pattern of exercise-induced dynamic hyperinflation. 相似文献
3.
Panagiotis Varagiannis Emmanuella Magriplis Grigoris Risvas Katerina Vamvouka Adamantia Nisianaki Anna Papageorgiou Panagiota Pervanidou George P. Chrousos Antonis Zampelas 《Nutrients》2021,13(2)
Childhood overweight and obesity prevalence has risen dramatically in the past decades, and family-based interventions may be an effective method to improve children’s eating behaviors. This study aimed to evaluate the effectiveness of three different family-based interventions: group-based, individual-based, or by website approach. Parents and school aged overweight or obese children, 8–12 years of age, were eligible for the study. A total of 115 children were randomly allocated in one of the three interventions, and 91 completed the study (79% compliance); Group 1 (n = 36) received group-based interventions by various experts; Group 2 (n = 30) had interpersonal family meetings with a dietitian; and Group 3 (n = 25) received training through a specifically developed website. Anthropometric, dietary, physical activity, and screen time outcomes were measured at baseline and at the end of the study. Within-group comparisons indicated significant improvement in body weight, body mass index (BMI)-z-score, physical activity, and screen time from baseline in all three study groups (p < 0.05). Furthermore, total body fat percentage (%TBF) was also decreased in Groups 2 and 3. Between-group differences varied with body weight and %TBF change, being larger in Group 3 compared to Groups 1 and 2, in contrast to BMI-z-score, screen time, and health behaviors, which were significantly larger in Group 2 than the other two groups. In conclusion, personalized family-based interventions are recommended to successfully improve children’s lifestyle and body weight status. 相似文献
4.
Prosthetic reconstruction of the femur for primary bone sarcoma 总被引:1,自引:1,他引:0
The survival of patients and implants, complications and functional outcome were reviewed in 25 consecutive femoral endoprosthetic
reconstructions for treatment of primary bone sarcoma. The diagnosis was chondrosarcoma in 11, osteosarcoma in 10, MFH in
3 and Ewing’s tumour in 1. Median follow up was 64 months (34 to 219) and median age at operation was 29 years (10 to 70).
Twelve remained disease free at review. One had amputation for local recurrence and another was alive with metastases. 11
patients died at a median of 13 months (5 to 128); 8 from metastatic disease and 3 from other causes. Four implants were revised,
at a median of 95 months (53 to 136); two for fractures of the stem and two for aseptic loosening. Three implants had radiological
evidence of loosening at a median of 43 months (34 to 49). Fourteen patients had significant complications. The median functional
score using the Musculoskeletal Tumour Society system was 68%. In our experience, prosthetic reconstruction of the femur does
not compromise survival, although there is a significant complication rate.
Accepted: 16 August 1999 相似文献
Résumé La survie des patients et des implants, les complications et le résultat fonctionnel ont étéétudiés dans 25 reconstructions prothétiques fémorales consécutives au traitement de sarcomes primaires de 1’os. Le diagnoctic était : ostéosarcome dans 11 cas, chondrosarcome dans 10, MFH dans 3 et tumeur d’Ewing dans 1. La médiane de suivie était de 64 mois (34 à 219) et la valeur médiane de 1’age à 1’opération était de 29 ans (10 à 70). 12 patients sont sans métastase ni récidive à la revue. Un a eu une amputation pour récidive locale et un autre est vivant avec métastases. 11 patients sont morts avec une médiane de 13 mois (5 à 128): 8 de méastases et 3 d’autres causes. 4 implants ont été réopérés avec une médiane de 95 mois (53 à 136) : 2 pour rupture de la tige et 2 pour descellement aseptique. 3 implants montraient un descellement radiologique à une médiane de 43 mois (34 à 49). 14 patients avaient des complications notables. Le score fonctionnel moyen utilisant la cotation de la Musculoskeletal tumor Society était de 68%. La reconstruction prothétique du fémur ne compromet pas la survie bien qu’il y ait un taux élevé de complications.
Accepted: 16 August 1999 相似文献
5.
Kostas Fasoulas Athanasios Beltsis Taxiarchis Katsinelos Eleni Dimou Mary Arvaniti Anna Charsoula Victor Gourvas Stefanos Atmatzidis Grigoris Chatzimavroudis Panagiotis Katsinelos 《Saudi Journal Of Gastroenterology》2012,18(2):146-148
Mesenteric panniculitis (MP) is a rare inflammatory and fibrotic disease of the mesentery of unknown etiology. It has various clinical and radiological manifestations, posing a diagnostic challenge for clinicians. Its diagnosis is indicated via radiologic imaging and is usually confirmed via peritoneal biopsies. We describe a case of a patient with histopathologically proven MP, in which steroid dependence was successfully managed with colchicine. 相似文献
6.
Gerotziafas GT Zarifis J Bandi A Mossialos L Galea V Tsinopoulos G Chaari M Baccouche H Sassi M Elalamy I 《Clinical and applied thrombosis/hemostasis》2012,18(4):356-363
Identification of outpatients with high platelet reactivity (HPR) on antiplatelet treatment is an unmet need. The present study was conducted in healthy individuals (n = 50) and in outpatients with coronary artery disease (CAD) at a distance from the acute ischemic episode (aspirin group, n = 71; aspirin/clopidogrel group, n = 106). We studied the feasibility and the precision of whole blood multiple electrode aggregometry (MEA) after triggering platelet aggregation by arachidonic acid or adenosine diphospate (ADP). The MEA can be performed on whole blood within 2 hours after sample venipuncture. The threshold for the diagnosis of HPR is situated at 55 and 50 U for the arachidonic acid and ADP test, respectively. Frequency of HPR was 7% and 20% in aspirin and aspirin/clopidogrel groups, respectively. In 3.8% of patients in aspirin/clopidogrel group, combined HPR on aspirin and clopidogrel was found. In outpatients with CAD, use of MEA is feasible for the diagnosis of HPR. 相似文献
7.
Konstantinos Panousis Peter Grigoris Ian Butcher Bardeep Rana James H Reilly David L Hamblen 《Acta orthopaedica》2013,84(3):341-346
Background The diagnosis of prosthetic infection remains a challenge, as no test is 100% sensitive and 100% specific Recent advances in molecular biology have enabled the detection of infection in culture negative cases.Patients and methods We evaluated the effectiveness of polymerase chain reaction (PCR) in detecting infection in failed joint replacements prospectively in 91 consecutive patients (92 prosthetic joints) undergoing revision total hip or knee arthroplasty. Synovial fluid was collected intraoperatively and examined by broad-range PCR assay for detection of bacterial DNA. The clinical diagnosis of infection was based on the results of blood tests, preoperative joint aspiration, culture and histology of multiple intraoperative tissue samples, as well as the surgeon's assessment.12 joints (13%) were infected, but the PCR was positive in 32 cases. The sensitivity of the technique was 92%, the specificity 74%, the accuracy 76%, the positive predictive value 34%, and the negative predictive value was 98%.Interpretation The PCR technique cannot be recommended for the routine detection of prosthetic infection. The large number of false positive results may represent sample contamination, or bacterial presence related to low-virulence organisms, low bacterial load, or a strong host immune response. 相似文献
8.
Stefanos Atmatzidis Grigoris Chatzimavroudis Ananias Ananiadis Spyros Kapoulas Konstantinos Atmatzidis 《Journal of gastrointestinal surgery》2013,17(8):1536-1537
Gastrointestinal stromal tumors (GISTs) represent a rare group of neoplasms of the digestive tract deriving from the mesenchyme. Giant GISTs (over 10 cm in diameter) represent only 20 % of all cases and are associated with a high risk of malignancy. We present the case of a giant GIST of the jejunum successfully treated by surgical resection and adjuvant therapy with imatinib. 相似文献
9.
10.
Evaluation of the pharmacological properties and clinical results of the synthetic pentasaccharide (fondaparinux) 总被引:5,自引:0,他引:5
Fondaparinux (Arixtra) is the first of a new class of selective indirect antithrombin-dependent factor Xa inhibitors, which inhibits thrombin generation. Fondaparinux is a completely synthetic pentasaccharide. It is a single molecular entity with a well-defined pharmacological target. Fondaparinux has nearly complete bioavailability after subcutaneous injection. The pharmacokinetics of fondaparinux appears predictable and consistent. The peak plasma level is obtained about 2 h after the subcutaneous injection, indicating that a rapid onset of antithrombotic activity is obtained on initiation of treatment. The elimination half-life is about 17 h and it is dose-independent, which allows a convenient once-daily dosing regimen. Fondaparinux is eliminated exclusively by the kidneys. Thus, the estimation of the renal function especially in elderly patients is important for the treatment with fondaparinux, whereas it is contraindicated in patients with severe renal insufficiency. Phase II clinical studies have identified a subcutaneous dose of 2.5 mg once daily for prophylaxis of venous thromboembolism in patients undergoing major orthopaedic surgery. Four phase-III clinical trials using bilateral phlebography for the diagnosis of DVT, demonstrated a combined 50% relative risk reduction of asymptomatic venous thromboembolic events in orthopaedic surgery patients in comparison to the low-molecular-weight heparin (LMWH) enoxaparin. Hemorrhagic complications for fondaparinux were either comparable or higher than those for LMWH but the authors did not judge that the increased bleeding was clinically relevant. A dose ranging study led to the selection of the dose of 7.5 mg at a single daily subcutaneous injection as optimal for the treatment of VTE. In two phase III clinical trials, the dose of 7.5 mg/day is expected to be as efficacious and safe as heparin for the treatment of DVT or PE, respectively. Phase II studies show that the efficacy-to-safety ratio of fondaparinux in the treatment of unstable angina or as an adjunct to thrombolysis in acute myocardial infarction is promising. These results demonstrated that a single anti-Xa agent devoid of antithrombin activity is a potent antithrombotic drug. Fondaparinux has obtained FDA and European health authorities approval. Its use on a large scale will allow the evaluation of its efficacy and tolerance in the daily clinical practice. Chemical modifications of the original synthetic pentasaccharide increase the affinity to AT resulting in a more potent inhibition of FXa and longer half-life. Idraparinux is the first of these new oligosaccharides that we named "meta-pentasaccharides." After subcutaneous injection the half-life of idraparinux is about 80 h allowing a single injection per week. A dose-finding study has established the optimal dose given once a week to be compared with warfarin for the treatment of DVT. 相似文献