全文获取类型
收费全文 | 1698篇 |
免费 | 145篇 |
国内免费 | 185篇 |
专业分类
耳鼻咽喉 | 6篇 |
儿科学 | 25篇 |
妇产科学 | 26篇 |
基础医学 | 226篇 |
口腔科学 | 34篇 |
临床医学 | 256篇 |
内科学 | 253篇 |
皮肤病学 | 10篇 |
神经病学 | 62篇 |
特种医学 | 77篇 |
外科学 | 206篇 |
综合类 | 303篇 |
预防医学 | 52篇 |
眼科学 | 41篇 |
药学 | 216篇 |
1篇 | |
中国医学 | 88篇 |
肿瘤学 | 146篇 |
出版年
2024年 | 9篇 |
2023年 | 35篇 |
2022年 | 59篇 |
2021年 | 89篇 |
2020年 | 66篇 |
2019年 | 48篇 |
2018年 | 63篇 |
2017年 | 49篇 |
2016年 | 41篇 |
2015年 | 76篇 |
2014年 | 82篇 |
2013年 | 99篇 |
2012年 | 123篇 |
2011年 | 122篇 |
2010年 | 84篇 |
2009年 | 70篇 |
2008年 | 86篇 |
2007年 | 132篇 |
2006年 | 69篇 |
2005年 | 89篇 |
2004年 | 52篇 |
2003年 | 63篇 |
2002年 | 47篇 |
2001年 | 37篇 |
2000年 | 21篇 |
1999年 | 25篇 |
1998年 | 36篇 |
1997年 | 40篇 |
1996年 | 39篇 |
1995年 | 28篇 |
1994年 | 24篇 |
1993年 | 23篇 |
1992年 | 21篇 |
1991年 | 20篇 |
1990年 | 10篇 |
1989年 | 12篇 |
1988年 | 15篇 |
1987年 | 6篇 |
1986年 | 4篇 |
1985年 | 3篇 |
1984年 | 4篇 |
1983年 | 1篇 |
1979年 | 1篇 |
1978年 | 1篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1969年 | 1篇 |
1968年 | 1篇 |
排序方式: 共有2028条查询结果,搜索用时 15 毫秒
1.
Y Gou?ffic T Piffeteau P Patra 《European journal of vascular and endovascular surgery》2007,33(2):220-222
Paradoxical embolism, describing the passage of venous or right-sided cardiac thrombus into the arterial or systemic circulation through patent foramen ovale, is an uncommon cause of acute arterial occlusion. Here, we report acute Leriche syndrome in a young woman attributable to paradoxical embolism. Ischaemia, patent foramen ovale, and venous thrombosis were the triad of evidence for paradoxical embolism. 相似文献
2.
3.
INVOLVEMENT OF NON-NMDA AND NMDA RECEPTORS IN GLUTAMATE-INDUCED PRESSOR OR DEPRESSOR RESPONSES OF THE PONS AND MEDULLA 总被引:1,自引:0,他引:1
SY Chen WC Wu CJ Tseng JS Kuo CY Chai 《Clinical and experimental pharmacology & physiology》1997,24(1):46-56
1. Fifty-five intact and six baroreceptor denervated and vagotomized cats of either sex were anaesthetized intraperito-neally with urethane (400 mg/kg) and a-chloralose (40 mg/kg). Responses of the systemic arterial pressure (SAP), mean SAP (MSAP) and sympathetic vertebral nerve (VNA) and renal nerve activities (RNA) were recorded. 2. In intact animals, monosodium L-glutamate (Glu, 0.1 mol/L, 50 nL) was microinjected into pressor areas of the locus coeruleus (LC), gigantocellular tegmental field (GTF), rostral ventrolateral medulla (RVLM) and dorsomedial medulla (DM), and the depressor areas of caudal ventrolateral medulla (CVLM). The induced actions were compared before and after microinjection of either glutamate antagonists, glutamate diethylester (GDEE, 0.5 mol/L, 50–100nL), a competitive AMPA receptor blocker, or 2-amino-5-phosphonovaleric acid (D-AP5, 0.025 mol/L, 50–100 nL), a competitive N-methyl-D-aspartate (NMDA) receptor blocker. GDEE completely blocked the increases of SAP and VNA elicited from all pressor areas. D-AP5 only partially blocked the pressor but slightly blocked VNA and RNA responses from LC, GTF and DM, particularly those from RVLM. Neither GDEE nor D-AP5 blocked the depressor responses of SAP and two nerve activities elicited from CVLM. 3. In baroreceptor denervated animals, NMDA (2 mmol/L, 50–100 nL) and AMPA (0.2 mmol/L, 50–100 nL) were micro-injected into the same pressor areas of GTF, RVLM and DM and the depressor area of CVLM responsive to Glu activation (0.1 mol/L, 30 nL). In RVLM, DM and CVLM, the results of either NMDA or AMPA were similar to those induced by Glu. However, in GTF, microinjection of either NMDA or AMPA did not induce similar responses to Glu. This suggests that the nature of GTF may differ from RVLM and DM. 4. The above results suggest that the Glu-induced pressor responses from LC, GTF, DM and especially RVLM, are primarily mediated through AMPA receptors. The Glu-induced depressor responses from CVLM may not be predominantly mediated by either AMPA or NMDA receptors. 5. In both baroreceptor-intact and -denervated cats stimulation of the pressor areas often produced an increase of VNA and a decrease of RNA, while in the depressor CVLM decreased both VNA and RNA. The VNA, but not RNA were positively correlated with the pressor responses, while both VNA and RNA were positively correlated with the depressor responses. This may suggest that neurons of the sympathetic vertebral and renal nerves are topographically organized in the brain. 相似文献
4.
Pernes JM; Vitoux JF; Brenoit P; Raynaud A; Parola JL; Roth JP; Angel CY; Fiessinger JN; Roncato M; Gaux JC 《Radiology》1986,158(2):481-485
Thirty-five patients hospitalized for recent angiographically documented arterial occlusion in the legs (27 femoropopliteal arteries and eight grafts) benefited from local fibrinolytic therapy delivered at the site of the occlusion with a 4- or 5-F catheter. This therapy combined a continuous urokinase (UK) infusion of 1,000 U/kg/hour and a lysyl plasminogen (LYS-PLG) infusion of 15 microkatals every 30 minutes. Angiographically confirmed lysis was obtained in 85% of the cases. Only 3% of the patients had major and 6% had minor groin hematomas. Only two patients had concentrations of fibrinogen as low as 100 mg/dl. Intravascular infusion of UK-LYS-PLG is as effective as streptokinase. Its excellent tolerance makes it a good alternative in the treatment of acute ischemia in the lower limbs. 相似文献
5.
6.
Gou Takeo Masakatsu Motomura Hidenori Matsuo Kiyosumi Ohishi Toshiro Yoshimura Shigenobu Nagataki Mitsuhiro Tsujihata 《Muscle & nerve》1993,16(8):840-848
We investigated the effect of the lgG from patients with myasthenia gravis (MG) on the degradation of normal rat junctional acetylcholine receptor (AChR) labeled with 125l-α-bungarotoxin (BuTx) and calculated the degradation rate (DR). The DR for the lgG from these patients was significantly higher than that from healthy volunteers and patients with other autoimmune diseases. For MG, DR was significantly correlated with the severity of the disease but not with anti-AChR antibody titer. DR was accelerated by lgG from patients with generalized MG whose antibody titers were in the normal range and by lgG from patients with ocular MG. These results indicate that measurement of the DR of junctional AChR in normal rats is more closely correlated with the severity of the disease than is measurement of anti-AChR antibody and that the former is a sensitive and confirmatory method for evaluating MG. © 1993 John Wiley & Sons, Inc. 相似文献
7.
8.
9.
Klinefelter综合征患者和双亲对诱变剂敏感性研究 总被引:1,自引:1,他引:1
为了解诱变剂对Klinefelter综合征发生的影响,对Klinefelter综合征患者,患者双亲及对照进行丝裂霉素C,乙醛或乙醇诱导非二倍体,染色体结构畸变及微核观察,发现丝裂霉素C诱导的患者当色体结构畸变和微核均显著多于对照和双亲,乙醛和乙醇能诱导非二倍体和微核增加,但患者和双亲增加的程度极显著高于对照,提示Klinefelter综合征患者对于丝裂霉素C,乙醛和乙醇诱导染色体畸变更敏感。双亲对 相似文献
10.
首次选用双相成核剂CaF2 和TiO2 为制备遮色瓷的成核剂 ,以SiO2 —Al2 O3 —K2 O—Na2 O系统为其基质成分 ,采用差热分析仪、扫描电镜和x衍射分析仪等实验手段来探讨本体系遮色瓷制备的热处理制度。结果表明阶梯制度的热处理方式适用于本体系的遮色瓷。瓷粉经过如下的热处理制度 :从室温以 8℃ /min的加热速度升温至 75 0℃保温 1h ,然后再以4℃ /min的升温速度升至 96 0℃ ,保温 2h后冷淬 ,其白榴石晶体的析晶行为良好 ,且晶体尺寸较小 (约 1μm左右 )。该热处理制度的确定为改善遮色瓷与金属的热匹配性和提高遮色瓷的理化性能提供了基础 相似文献